An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia

• Published in: Mucosal immunology Vol. 7; no. 4; pp. 983 - 994
• Main Authors: Dillon, S M, Lee, E J, Kotter, C V, Austin, G L, Dong, Z, Hecht, D K, Gianella, S, Siewe, B, Smith, D M, Landay, A L, Robertson, C E, Frank, D N, Wilson, C C
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.07.2014; Nature Publishing Group US; Elsevier Limited
• Subjects: 631/250/256/1980; 631/250/347; 692/698/2741/2135; 692/699/255/1901; Adult; Allergology; Antibodies; Biodiversity; Biomedical and Life Sciences; Biomedicine; Biopsy; Body Mass Index; CD4 Lymphocyte Count; Colon - immunology; Colon - microbiology; Colon - pathology; Diet; Dysbiosis - immunology; Endotoxemia - immunology; Female; Gastroenterology; HIV Infections - immunology; HIV Infections - virology; HIV-1 - immunology; Humans; Immunity; Immunology; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Lymphocyte Activation - immunology; Male; Microbiota; Middle Aged; T-Lymphocyte Subsets - immunology; Viral Load; Young Adult

Human immunodeficiency virus-1 (HIV-1) infection disrupts the intestinal immune system, leading to microbial translocation and systemic immune activation. We investigated the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-cell and dendritic cell (DC) freque...