Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

• Published in: Journal of applied physiology (1985) Vol. 110; no. 6; pp. 1582 - 1591
• Main Authors: Kenjale, Aarti A., Ham, Katherine L., Stabler, Thomas, Robbins, Jennifer L., Johnson, Johanna L., VanBruggen, Mitch, Privette, Grayson, Yim, Eunji, Kraus, William E., Allen, Jason D.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.06.2011
• Subjects: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Bioavailability; Biological and medical sciences; Blood Pressure; Cross-Over Studies; Dietary Supplements; Exercise; Exercise Test; Exercise Tolerance; Female; Fundamental and applied biological sciences. Psychology; Heart Rate; Hemoglobins - metabolism; Human performance; Humans; Hypoxia; Infrared spectroscopy; Intermittent Claudication - blood; Intermittent Claudication - physiopathology; Intermittent Claudication - prevention & control; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Nitrates - administration & dosage; Nitrates - metabolism; Nitric oxide; Nitric Oxide - blood; Nitrites - blood; North Carolina; Oxygen Consumption; Oxygenation; Oxyhemoglobins - metabolism; Pain; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - physiopathology; Peripheral Arterial Disease - therapy; Plant Roots; Spectroscopy, Near-Infrared; Time Factors; Treatment Outcome; Vasodilation; Vein & artery diseases; Walking; North Carolina; Physical exercise; Cardiovascular disease; exercise; Nitrates; peripheral arterial disease; Arterial disease; Vascular disease; Vertebrata; Mammalia; nitrite; Nitric oxide; Occlusive arterial disease; Supplementation; Performance

Peripheral arterial disease (PAD) results in a failure to adequately supply blood and oxygen (O 2 ) to working tissues and presents as claudication pain during walking. Nitric oxide (NO) bioavailability is essential for vascular health and function. Plasma nitrite (NO 2 − ) is a marker of vascular N...