Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload

• Published in: Journal of hepatology Vol. 49; no. 1; pp. 123 - 133
• Main Authors: Barisani, Donatella, Pelucchi, Sara, Mariani, Raffaella, Galimberti, Stefania, Trombini, Paola, Fumagalli, Daniela, Meneveri, Raffaella, Nemeth, Elizabeta, Ganz, Tomas, Piperno, Alberto
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.07.2008; Elsevier
• Subjects: Adult; Aged; Antigens, CD - genetics; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - urine; Biological and medical sciences; Biopsy; Cation Transport Proteins - genetics; Ceruloplasmin - genetics; Female; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Genotype; Hemochromatosis; Hemochromatosis - genetics; Hemochromatosis - urine; Hepcidin; Hepcidins; Humans; Iron - metabolism; Iron overload; Iron Overload - genetics; Iron Overload - urine; Liver Diseases - genetics; Liver Diseases - pathology; Liver Diseases - urine; Male; Medical sciences; Membrane Proteins - genetics; Metabolic diseases; Metals (hemochromatosis...); Middle Aged; Other metabolic disorders; Quantitative-PCR; Receptors, Transferrin - genetics; RNA, Messenger - metabolism; Transferrin Receptor; Iron overload; TfR; NAFLD; Hemochromatosis; BMP; Transferrin Receptor; DHIO; FP; Gene expression; HFE-HH; HIS; Quantitative-PCR; PIS; SIS; Hepcidin; TIS; Portal Iron Score; Dysmetabolic Hepatic Iron Overload; Non-Alcoholic Fatty Liver Disease; Sinusoidal Iron Score; Hepatocyte Iron Score; ferroportin; bone morphogenetic protein; HFE-hemochromatosis; Total Iron Score; Human; Transferrin; Liver; Metabolic diseases; Iron; Enzymopathy; Polymerase chain reaction; Gastroenterology; Molecular biology; Quantitative analysis

Many patients with hepatic iron overload do not have identifiable mutations and often present with metabolic disorders and hepatic steatosis. Since the pathophysiology of Dysmetabolic Hepatic Iron Overload (DHIO) is still obscure, the aim of this study was to evaluate, in these patients, possible al...