Organ/body-on-a-chip based on microfluidic technology for drug discovery

• Published in: Drug metabolism and pharmacokinetics Vol. 33; no. 1; pp. 43 - 48
• Main Authors: Kimura, Hiroshi, Sakai, Yasuyuki, Fujii, Teruo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2018
• Subjects: ADME; Animal testing; Body-on-a-chip; Cell-based assay; Drug discovery; Microfluidic device; Organ-on-a-chip; Body-on-a-chip; Animal testing; ADME; Organ-on-a-chip; Cell-based assay; Drug discovery; Microfluidic device

Although animal experiments are indispensable for preclinical screening in the drug discovery process, various issues such as ethical considerations and species differences remain. To solve these issues, cell-based assays using human-derived cells have been actively pursued. However, it remains diff...