Absorption and Metabolism of Adenine, Adenosine-5'-Monophosphate, Adenosine and Hypoxanthine by the Isolated Vascularly Perfused Rat Small Intestine
Intestinal vascular perfusion and in vivo live animal experiments were conducted in order to evaluate the nature and extent of the intestinal metabolism of adenine, adenosine, adenosine-5′-monophosphate (AMP) and hypoxanthine in the rat. Radiolabeled purine substrates were administered intralumenall...
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Published in | The Journal of nutrition Vol. 114; no. 4; pp. 753 - 760 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Elsevier Inc
01.04.1984
American Society for Nutritional Sciences |
Subjects | |
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Abstract | Intestinal vascular perfusion and in vivo live animal experiments were conducted in order to evaluate the nature and extent of the intestinal metabolism of adenine, adenosine, adenosine-5′-monophosphate (AMP) and hypoxanthine in the rat. Radiolabeled purine substrates were administered intralumenally. Intestinal contents, tissue and/or portal flow were collected and evaluated for resultant purine metabolites by liquid and paper chromatography and paper electrophoresis. Adenosine, AMP and hypoxanthine were quantitatively metabolized to end products (primarily uric acid) within 15 minutes after administration. In contrast, the metabolism of adenine to uric acid was considerably slower. Up to 20% of the administered adenine was recovered unmetabolized in the portal vasculature. Nonetheless uric acid was the primary metabolite recovered from the portal circulation in the isolated intestine regardless of the purine substrate or concentration administered. Since lumenal inosine concentrations rose sharply with increasing doses of AMP, either transport or metabolism of inosine is a rate-limiting step in the intestinal metabolism of purines to uric acid in the rat. Finally, the large percentage of the radiolabel in uric acid recovered in the lumen is consistent with the hypothesis that the intestine is an extrarenal site for purine excretion. |
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AbstractList | Intestinal vascular perfusion and in vivo live animal experiments were conducted in order to evaluate the nature and extent of the intestinal metabolism of adenine, adenosine, adenosine-5'-monophosphate (AMP) and hypoxanthine in the rat. Radiolabeled purine substrates were administered intralumenally. Intestinal contents, tissue and/or portal flow were collected and evaluated for resultant purine metabolites by liquid and paper chromatography and paper electrophoresis. Adenosine, AMP and hypoxanthine were quantitatively metabolized to end products (primarily uric acid) within 15 minutes after administration. In contrast, the metabolism of adenine to uric acid was considerably slower. Up to 20% of the administered adenine was recovered unmetabolized in the portal vasculature. Nonetheless uric acid was the primary metabolite recovered from the portal circulation in the isolated intestine regardless of the purine substrate or concentration administered. Since lumenal inosine concentrations rose sharply with increasing doses of AMP, either transport or metabolism of inosine is a rate-limiting step in the intestinal metabolism of purines to uric acid in the rat. Finally, the large percentage of the radiolabel in uric acid recovered in the lumen is consistent with the hypothesis that the intestine is an extrarenal site for purine excretion. |
Author | Salati, Lisa M. Henderson, LaVell M. Gross, Carol J. Savaiano, Dennis A. |
Author_xml | – sequence: 1 givenname: Lisa M. surname: Salati fullname: Salati, Lisa M. – sequence: 2 givenname: Carol J. surname: Gross fullname: Gross, Carol J. – sequence: 3 givenname: LaVell M. surname: Henderson fullname: Henderson, LaVell M. – sequence: 4 givenname: Dennis A. surname: Savaiano fullname: Savaiano, Dennis A. |
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Keywords | adenosine intestine AMP hypoxanthine uric acid adenine Vertebrata Adenosine Mammalia Absorption Rat Digestive system Rodentia Hypoxanthine Nucleoside Metabolism Small intestine |
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SubjectTerms | Absorption adenine Adenine - metabolism adenosine Adenosine - metabolism Adenosine Monophosphate - metabolism AMP Animals Biological and medical sciences Carbon Radioisotopes Fundamental and applied biological sciences. Psychology human nutrition Hypoxanthine Hypoxanthines - metabolism intestine Intestine, Small - metabolism Intestine. Mesentery Male nutrition physiology Rats Rats, Inbred Strains uric acid Vertebrates: digestive system |
Title | Absorption and Metabolism of Adenine, Adenosine-5'-Monophosphate, Adenosine and Hypoxanthine by the Isolated Vascularly Perfused Rat Small Intestine |
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