Novel focal adhesion kinase 1 inhibitor sensitizes lung cancer cells to radiation in a p53-independent manner

• Published in: International journal of oncology Vol. 51; no. 5; pp. 1583 - 1589
• Main Authors: Jung, Seung-Youn, Kho, Seongho, Song, Kyung-Hee, Ahn, Jiyeon, Park, In-Chul, Nam, Ky-Youb, Hwang, Sang-Gu, Nam, Seon-Young, Cho, Seong-Jun, Song, Jie-Young
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.11.2017; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Angiogenesis; Animals; Apoptosis - drug effects; Apoptosis - radiation effects; Benzamides - administration & dosage; Benzamides - chemical synthesis; Cancer; Cancer therapies; Care and treatment; Cell adhesion & migration; Cell culture; Cell cycle; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - radiation effects; Cell Proliferation - drug effects; Cell Proliferation - radiation effects; cyclin D1; Development and progression; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - radiation effects; FAK1; Focal Adhesion Kinase 1 - antagonists & inhibitors; Focal Adhesion Kinase 1 - genetics; G1 Phase Cell Cycle Checkpoints - drug effects; G1 Phase Cell Cycle Checkpoints - radiation effects; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Growth factors; Health aspects; Humans; Kinases; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Metastasis; Mice; Ovarian cancer; Phosphorylation; Phosphotransferases; pRb; Proteins; Radiation; Radiation Tolerance - drug effects; Radiation Tolerance - genetics; radiosensitivity; Retina; Retinoblastoma; Studies; Tumor Microenvironment - drug effects; Tumor Microenvironment - radiation effects; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumors; Xenograft Model Antitumor Assays

Focal adhesion kinase 1 (FAK1) is known to promote tumor progression and metastasis by controlling cell movement, invasion, survival and the epithelial-to-mesenchymal transition in the tumor microenvironment. As recent reports imply that FAK1 is highly associated with tumor cell development and mali...