Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway

• Published in: International journal of oncology Vol. 49; no. 6; pp. 2600 - 2610
• Main Authors: Feng, Xiaoning, Jiang, Jingjin, Shi, Shaohua, Xie, Haiyang, Zhou, Lin, Zheng, Shusen
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Animals; Apoptosis; Apoptosis - genetics; bcl-Associated Death Protein - metabolism; Binding sites; Cancer therapies; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Care and treatment; Cell Line, Tumor; Cellular signal transduction; Development and progression; Drug resistance; Gastric cancer; Gene Knockdown Techniques; Genetic aspects; Health aspects; Hep G2 Cells; Humans; Laboratory animals; Liver cancer; liver cancer stem cells; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNA; MicroRNAs - genetics; miR-25; Mitochondria - metabolism; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - pathology; Oligonucleotides, Antisense - genetics; phosphatase and tensin homologue; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; Reactive Oxygen Species - metabolism; resistance; Signal Transduction - genetics; Stem cells; Studies; TNF-related apoptosis-inducing ligand; TNF-Related Apoptosis-Inducing Ligand - genetics; TNF-Related Apoptosis-Inducing Ligand - metabolism; Tumor necrosis factor-TNF; Xenograft Model Antitumor Assays; United States > US; China

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is considered as a promising anticancer agent, it induced apoptosis in cancer cells selectively without damaging the normal tissue cells. However, the resistance of cancer cells to TRAIL limits its application. Since the cancer st...