Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

• Published in: Frontiers in molecular neuroscience Vol. 11; p. 236
• Main Authors: Wei, Zexu, Li, Xiaowan, Li, Xixi, Liu, Qingshan, Cheng, Yong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 05.07.2018; Frontiers Media S.A
• Subjects: 8-Hydroxydeoxyguanosine; Alzheimer's disease; Antioxidants; Biomarkers; Blood levels; Brain; Brain-derived neurotrophic factor; Catalase; Cerebrospinal fluid; Ceruloplasmin; Cholesterol; Cytokines; Ferritin; Free radicals; Glutathione peroxidase; High density lipoprotein; Hydrogen peroxide; Lactoferrin; Low density lipoprotein; Meta-analysis; Movement disorders; Neurodegenerative diseases; Neuroscience; Oxidative stress; Parkinson's disease; Peripheral blood; Sample size; Standard deviation; Studies; Systematic review; Transferrins; Triglycerides; Tumor necrosis factor-TNF; Uric acid; Vitamin E; China; meta-analysis; Parkinson's disease; peripheral blood; oxidative stress; cerebrospinal fluid

Oxidative stress has been suggested to play a key role in Parkinson's disease, but inconsistent results were found in clinical studies. This study sought to quantitatively summarize the blood and cerebrospinal fluid (CSF) oxidative stress marker data in PD patients. We performed a systematic se...