Physiology and Pharmacology of Erythropoietin

• Published in: Transfusion medicine and hemotherapy Vol. 40; no. 5; pp. 302 - 309
• Main Author: Jelkmann, Wolfgang
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger GmbH 01.10.2013
• Subjects: Review; Review Article; Erythrocytic progenitors; Hypoxia; Chronic kidney disease; Red blood cells; Recombinant human erythropoietin; Anemia

Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165 amino acid residues chain to which four glycans are attached. The kidneys are the primary sources of Epo, its synthesis is controlled by hypoxia-inducible transcription factors (HIFs). Epo is an essential factor f...