Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 303; no. 6; pp. G675 - G685
• Main Authors: Bajaj, Jasmohan S., Hylemon, Phillip B., Ridlon, Jason M., Heuman, Douglas M., Daita, Kalyani, White, Melanie B., Monteith, Pamela, Noble, Nicole A., Sikaroodi, Masoumeh, Gillevet, Patrick M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.09.2012
• Series: Innovative and Emerging Technologies in GI Physiology and Disease
• Subjects: Adult; Bacteria; Bacteria - classification; Call for Papers; Cognition & reasoning; Cognition - physiology; Colon - microbiology; Comparative analysis; Electroencephalography; Feces - microbiology; Female; Hepatic Encephalopathy - complications; Hepatic Encephalopathy - microbiology; Humans; Inflammation - complications; Intestinal Mucosa - microbiology; Liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - microbiology; Male; Middle Aged

Although hepatic encephalopathy (HE) is linked to the gut microbiota, stool microbiome analysis has not found differences between HE and no-HE patients. This study aimed to compare sigmoid mucosal microbiome of cirrhotic patients to controls, between HE vs. no-HE patients, and to study their linkage...