Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells

Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously be...

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Published in	Biochemical pharmacology Vol. 70; no. 8; pp. 1167 - 1175
Main Authors	Zemani, Faouzia, Benisvy, Danielle, Galy-Fauroux, Isabelle, Lokajczyk, Anna, Colliec-Jouault, Sylvia, Uzan, Georges, Fischer, Anne Marie, Boisson-Vidal, Catherine
Format	Journal Article
Language	English
Published	New York, NY Elsevier Inc 15.10.2005 Elsevier Science
Subjects	Alpha #6 Angiogenesis Biological and medical sciences Cardiovascular system Cell Proliferation Cell Separation Cells, Cultured Endothelial progenitor cells Endothelium - cytology Endothelium - drug effects FGF-2 Fibroblast Growth Factor 2 - metabolism Flow Cytometry Fucoidan Humans Laminin - metabolism Medical sciences Miscellaneous Molecular Weight Neovascularization, Physiologic Pharmacology. Drug treatments Phenotype Polysaccharides - chemistry Polysaccharides - pharmacology Stem Cells - cytology Stem Cells - drug effects PBS vWF VEGF Alpha #6 FACS Fucoidan ECM FGF-2 Angiogenesis FCS Endothelial progenitor cells KDR EPC HUVEC Endothelial cell Phenotype Stem cell Precursor cell Plant origin Basic fibroblast growth factor Neovascularization Molecular mass Progenitor cell
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Abstract	Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously been shown to potentiate in vitro tube formation by mature endothelial cells in the presence of basic fibroblast growth factor (FGF-2). We therefore examined whether fucoidan, alone or combined with FGF-2, could increase EPC proangiogenic potency in vitro. EPC exposure to 10 μg/ml fucoidan induced a proangiogenic phenotype, including cell proliferation ( p < 0.01) and migration ( p < 0.01); moreover, differentiation into vascular cords occurred in the presence of FGF-2 ( p < 0.01). This latter effect correlated with upregulation of the cell-surface #α6 integrin subunit of the laminin receptor ( p < 0.05). Compared to untreated HUVEC, untreated EPC #α6 expression and adhesion to laminin were enhanced two-fold. Fucoidan treatment further enhanced HUVEC but not EPC adhesion to laminin. These results show that fucoidan enhances the proangiogenic properties of EPC and suggest that ex vivo fucoidan preconditioning of EPC might lead to increased neovascularization when injected into ischemic tissues.
AbstractList	Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously been shown to potentiate in vitro tube formation by mature endothelial cells in the presence of basic fibroblast growth factor (FGF-2). We therefore examined whether fucoidan, alone or combined with FGF-2, could increase EPC proangiogenic potency in vitro. EPC exposure to 10 μg/ml fucoidan induced a proangiogenic phenotype, including cell proliferation ( p < 0.01) and migration ( p < 0.01); moreover, differentiation into vascular cords occurred in the presence of FGF-2 ( p < 0.01). This latter effect correlated with upregulation of the cell-surface #α6 integrin subunit of the laminin receptor ( p < 0.05). Compared to untreated HUVEC, untreated EPC #α6 expression and adhesion to laminin were enhanced two-fold. Fucoidan treatment further enhanced HUVEC but not EPC adhesion to laminin. These results show that fucoidan enhances the proangiogenic properties of EPC and suggest that ex vivo fucoidan preconditioning of EPC might lead to increased neovascularization when injected into ischemic tissues. Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously been shown to potentiate in vitro tube formation by mature endothelial cells in the presence of basic fibroblast growth factor (FGF-2). We therefore examined whether fucoidan, alone or combined with FGF-2, could increase EPC proangiogenic potency in vitro. EPC exposure to 10 microg/ml fucoidan induced a proangiogenic phenotype, including cell proliferation (p < 0.01) and migration (p < 0.01); moreover, differentiation into vascular cords occurred in the presence of FGF-2 (p < 0.01). This latter effect correlated with upregulation of the cell-surface #alpha6 integrin subunit of the laminin receptor (p < 0.05). Compared to untreated HUVEC, untreated EPC #alpha6 expression and adhesion to laminin were enhanced two-fold. Fucoidan treatment further enhanced HUVEC but not EPC adhesion to laminin. These results show that fucoidan enhances the proangiogenic properties of EPC and suggest that ex vivo fucoidan preconditioning of EPC might lead to increased neovascularization when injected into ischemic tissues. Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously been shown to potentiate in vitro tube formation by mature endothelial cells in the presence of basic fibroblast growth factor (FGF-2). We therefore examined whether fucoidan, alone or combined with FGF-2, could increase EPC proangiogenic potency in vitro. EPC exposure to 10 microg/ml fucoidan induced a proangiogenic phenotype, including cell proliferation (p < 0.01) and migration (p < 0.01); moreover, differentiation into vascular cords occurred in the presence of FGF-2 (p < 0.01). This latter effect correlated with upregulation of the cell-surface #alpha6 integrin subunit of the laminin receptor (p < 0.05). Compared to untreated HUVEC, untreated EPC #alpha6 expression and adhesion to laminin were enhanced two-fold. Fucoidan treatment further enhanced HUVEC but not EPC adhesion to laminin. These results show that fucoidan enhances the proangiogenic properties of EPC and suggest that ex vivo fucoidan preconditioning of EPC might lead to increased neovascularization when injected into ischemic tissues.Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is relatively small, it may thus be necessary to enhance their proangiogenic properties ex vivo prior to injection in vivo. Fucoidan has previously been shown to potentiate in vitro tube formation by mature endothelial cells in the presence of basic fibroblast growth factor (FGF-2). We therefore examined whether fucoidan, alone or combined with FGF-2, could increase EPC proangiogenic potency in vitro. EPC exposure to 10 microg/ml fucoidan induced a proangiogenic phenotype, including cell proliferation (p < 0.01) and migration (p < 0.01); moreover, differentiation into vascular cords occurred in the presence of FGF-2 (p < 0.01). This latter effect correlated with upregulation of the cell-surface #alpha6 integrin subunit of the laminin receptor (p < 0.05). Compared to untreated HUVEC, untreated EPC #alpha6 expression and adhesion to laminin were enhanced two-fold. Fucoidan treatment further enhanced HUVEC but not EPC adhesion to laminin. These results show that fucoidan enhances the proangiogenic properties of EPC and suggest that ex vivo fucoidan preconditioning of EPC might lead to increased neovascularization when injected into ischemic tissues.
Author	Uzan, Georges Galy-Fauroux, Isabelle Zemani, Faouzia Boisson-Vidal, Catherine Colliec-Jouault, Sylvia Benisvy, Danielle Lokajczyk, Anna Fischer, Anne Marie
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Keywords	PBS vWF VEGF Alpha #6 FACS Fucoidan ECM FGF-2 Angiogenesis FCS Endothelial progenitor cells KDR EPC HUVEC Endothelial cell Phenotype Stem cell Precursor cell Plant origin Basic fibroblast growth factor Neovascularization Molecular mass Progenitor cell
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Snippet	Endothelial progenitor cell (EPC) transplantation is a potential means of inducing neovascularization in vivo. However, the number of circulating EPC is...
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SubjectTerms	Alpha #6 Angiogenesis Biological and medical sciences Cardiovascular system Cell Proliferation Cell Separation Cells, Cultured Endothelial progenitor cells Endothelium - cytology Endothelium - drug effects FGF-2 Fibroblast Growth Factor 2 - metabolism Flow Cytometry Fucoidan Humans Laminin - metabolism Medical sciences Miscellaneous Molecular Weight Neovascularization, Physiologic Pharmacology. Drug treatments Phenotype Polysaccharides - chemistry Polysaccharides - pharmacology Stem Cells - cytology Stem Cells - drug effects
Title	Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells
URI	https://dx.doi.org/10.1016/j.bcp.2005.07.014 https://www.ncbi.nlm.nih.gov/pubmed/16153611 https://www.proquest.com/docview/68593875
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