Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells

• Published in: Drug metabolism and pharmacokinetics Vol. 35; no. 4; pp. 374 - 382
• Main Authors: Kabeya, Tomoki, Mima, Shinji, Imakura, Yuki, Miyashita, Toshihide, Ogura, Izumi, Yamada, Tadanori, Yasujima, Tomoya, Yuasa, Hiroaki, Iwao, Takahiro, Matsunaga, Tamihide
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2020
• Subjects: Alkanesulfonic Acids - pharmacokinetics; Caco-2 Cells; Caco-2 cells; Cells, Cultured; Cyclosporins - pharmacokinetics; CYP3A4/5 activities; Differentiation; Digoxin - pharmacokinetics; Dipeptides - pharmacokinetics; Drug membrane permeability; Epithelial Cells - metabolism; Forskolin; Human iPS cell-derived small intestinal epithelial cells; Human primary small intestinal cells; Humans; Ibuprofen - pharmacokinetics; Induced Pluripotent Stem Cells - metabolism; Intestine, Small - cytology; Intestine, Small - metabolism; Morpholines - pharmacokinetics; Drug membrane permeability; CYP3A4/5 activities; Forskolin; Human iPS cell-derived small intestinal epithelial cells; Human primary small intestinal cells; Differentiation; Caco-2 cells

To develop a novel intestinal drug absorption system using intestinal epithelial cells derived from human induced pluripotent stem (iPS) cells, the cells must possess sufficient pharmacokinetic functions. However, the CYP3A4/5 activities of human iPS cell-derived small intestinal epithelial cells pr...