Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy

• Published in: Journal of allergy and clinical immunology Vol. 142; no. 1; pp. 335 - 338.e9
• Main Authors: Lee-Sarwar, Kathleen, Kelly, Rachel S., Lasky-Su, Jessica, Moody, D. Branch, Mola, Alex R., Cheng, Tan-Yun, Comstock, Laurie E., Zeiger, Robert S., O'Connor, George T., Sandel, Megan T., Bacharier, Leonard B., Beigelman, Avraham, Laranjo, Nancy, Gold, Diane R., Bunyavanich, Supinda, Savage, Jessica H., Weiss, Scott T., Brennan, Patrick J., Litonjua, Augusto A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2018; Elsevier Limited
• Subjects: Age; Antigens; Asthma; Bacteroides; Bacteroides fragilis - metabolism; Cesarean section; Child, Preschool; Children; Eigenvalues; Feces; Female; Food allergies; Food Hypersensitivity - immunology; Food Hypersensitivity - metabolism; Food Hypersensitivity - microbiology; Gastrointestinal Microbiome - immunology; Genotype & phenotype; Humans; Hypotheses; Infant; Intestine; Lipids; Male; Mediation; Metabolites; Natural Killer T-Cells - immunology; Pruritus; Sphingolipids; Sphingolipids - immunology; Sphingolipids - metabolism

[...]we adjusted for age in all analyses, performed sensitivity analyses of key results adjusting for other potential confounders, and tested for associations between mode of delivery and phenotype-associated microbiome and metabolome perturbations. [...]fecal lipid iNKT-cell activation was signific...