Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

• Published in: Frontiers in neuroscience Vol. 12; p. 301
• Main Authors: Luan, Yanan, Ren, Xiangpeng, Zheng, Wu, Zeng, Zhenhai, Guo, Yingzi, Hou, Zhidong, Guo, Wei, Chen, Xingjun, Li, Fei, Chen, Jiang-Fan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 02.05.2018; Frontiers Media S.A
• Subjects: Animal cognition; Apoptosis; Astrocytes; Autophagy; Axons; Caffeine; Cell death; Cortex; Dopamine receptors; Epidemiology; Fibrils; Laboratory animals; Lewy bodies; macroautophagy; Medulla oblongata; Mesencephalon; Microglia; Microtubule-associated protein 1; Movement disorders; Neostriatum; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurons; Neuroscience; Neurotoxicity; Parkinson's disease; Pathogenesis; Pathology; Phagocytosis; Studies; Synuclein; α-synuclein; α-synucleinopathy; United States > US; China; caffeine; Parkinson's disease; autophagy; striatum; macroautophagy; α-synucleinopathy; α-synuclein

Despite converging epidemiological evidence for the inverse relationship of regular caffeine consumption and risk of developing Parkinson's disease (PD) with animal studies demonstrating protective effect of caffeine in various neurotoxin models of PD, whether caffeine can protect against mutan...