The role of respiratory epithelium in host defence against influenza virus infection

• Published in: Biomedical Journal Vol. 41; no. 4; pp. 218 - 233
• Main Authors: Denney, Laura, Ho, Ling-Pei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.08.2018; Chang Gung University; Elsevier
• Subjects: Acids; Antiinfectives and antibacterials; Cell Polarity; Chemokines - physiology; Cytokines - physiology; DEAD Box Protein 58 - physiology; Defense; Epithelium; Homeostasis; Humans; Immune system; Infections; Influenza; Influenza, Human - immunology; Interferons - physiology; Lungs; Maintenance; Microorganisms; Mucous membrane; Neutrophils; NLR Proteins - physiology; Proteins; Regulatory mechanisms (biology); Respiratory Mucosa - immunology; Respiratory tract; Special Edition; Surfactants; Tight Junctions - physiology; Toll-Like Receptors - physiology; Viruses; Injury and repair; Sensing; Airway epithelium; Influenza; Defence

The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus in...