The role of respiratory epithelium in host defence against influenza virus infection

The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus in...

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Bibliographic Details
Published inBiomedical Journal Vol. 41; no. 4; pp. 218 - 233
Main Authors Denney, Laura, Ho, Ling-Pei
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 01.08.2018
Chang Gung University
Elsevier
Subjects
Acids
Antiinfectives and antibacterials
Cell Polarity
Chemokines - physiology
Cytokines - physiology
DEAD Box Protein 58 - physiology
Defense
Epithelium
Homeostasis
Humans
Immune system
Infections
Influenza
Influenza, Human - immunology
Interferons - physiology
Lungs
Maintenance
Microorganisms
Mucous membrane
Neutrophils
NLR Proteins - physiology
Proteins
Regulatory mechanisms (biology)
Respiratory Mucosa - immunology
Respiratory tract
Special Edition
Surfactants
Tight Junctions - physiology
Toll-Like Receptors - physiology
Viruses
Injury and repair
Sensing
Airway epithelium
Influenza
Defence
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Abstract The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
AbstractList The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection. Keywords: Influenza, Airway epithelium, Defence, Sensing, Injury and repair
Author Denney, Laura
Ho, Ling-Pei
AuthorAffiliation MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
AuthorAffiliation_xml – name: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Author_xml – sequence: 1
  givenname: Laura
  surname: Denney
  fullname: Denney, Laura
– sequence: 2
  givenname: Ling-Pei
  surname: Ho
  fullname: Ho, Ling-Pei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30348265$$D View this record in MEDLINE/PubMed
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Tue Aug 05 09:43:19 EDT 2025
Fri Jul 25 11:10:04 EDT 2025
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Tue Jul 01 02:17:42 EDT 2025
Thu Apr 24 22:55:57 EDT 2025
IsDoiOpenAccess true
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Issue 4
Keywords Injury and repair
Sensing
Airway epithelium
Influenza
Defence
Language English
License Copyright © 2018 Chang Gung University. Published by Elsevier B.V. All rights reserved.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Snippet The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory...
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SubjectTerms Acids
Antiinfectives and antibacterials
Cell Polarity
Chemokines - physiology
Cytokines - physiology
DEAD Box Protein 58 - physiology
Defense
Epithelium
Homeostasis
Humans
Immune system
Infections
Influenza
Influenza, Human - immunology
Interferons - physiology
Lungs
Maintenance
Microorganisms
Mucous membrane
Neutrophils
NLR Proteins - physiology
Proteins
Regulatory mechanisms (biology)
Respiratory Mucosa - immunology
Respiratory tract
Special Edition
Surfactants
Tight Junctions - physiology
Toll-Like Receptors - physiology
Viruses
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Title The role of respiratory epithelium in host defence against influenza virus infection
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