The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells

Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such a...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in molecular neuroscience Vol. 10; p. 258
Main Authors Cortés, Daniel, Carballo-Molina, Oscar A, Castellanos-Montiel, María José, Velasco, Iván
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 22.08.2017
Frontiers Media S.A
Subjects
Axonogenesis
Axons
Cell proliferation
Cell survival
Dopamine receptors
dopaminergic neurons
electrophysiological maturation
Enteric nervous system
Glial cell line-derived neurotrophic factor
Glioblastoma
Hydroxylase
motor neuron
Motor neurons
Nervous system
Neural stem cells
Neuroblastoma
neurogenesis
Neuronal-glial interactions
Neuroscience
Neurosciences
Nuclear receptors
Nurr1 protein
pain
Phenotypes
Stem cells
Survival factor
Tyrosine 3-monooxygenase
Mexico
pain
glioblastoma
motor neuron
dopaminergic neurons
neuroblastoma
neurogenesis
enteric nervous system
electrophysiological maturation
Online AccessGet full text

Cover

Abstract Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions.
AbstractList Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions.
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting factor for dopaminergic neurons. Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a factor supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase, Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons, GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions.
Author Velasco, Iván
Carballo-Molina, Oscar A
Castellanos-Montiel, María José
Cortés, Daniel
AuthorAffiliation 1 Instituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de México México City, Mexico
2 Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y Neurología México City, Mexico
AuthorAffiliation_xml – name: 2 Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y Neurología México City, Mexico
– name: 1 Instituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de México México City, Mexico
Author_xml – sequence: 1
  givenname: Daniel
  surname: Cortés
  fullname: Cortés, Daniel
  organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico
– sequence: 2
  givenname: Oscar A
  surname: Carballo-Molina
  fullname: Carballo-Molina, Oscar A
  organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico
– sequence: 3
  givenname: María José
  surname: Castellanos-Montiel
  fullname: Castellanos-Montiel, María José
  organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico
– sequence: 4
  givenname: Iván
  surname: Velasco
  fullname: Velasco, Iván
  organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28878618$$D View this record in MEDLINE/PubMed
BookMark eNpdks1vEzEQxS1URD_gzgmtxIXLhrG967UvSCj9oFJUDhRxtBx7tnG0sYO9G4n_HjcJVcvJ1vObnzwz75ychBiQkPcUZpxL9bkPmzjMGNBuBsBa-YqcUSFY3YJSJ8_up-Q85zWAYKLlb8gpk7KTgsoz8ut-hdVdDPWPKe38zgzVVd-jHXMV--pm8EWY4zBUCx-wvsTkd-iqO5xSHFPcrrytro0dY6pi2MtHf35LXvdmyPjueF6Qn9dX9_Nv9eL7ze3866K2jYKxFqwTBjmgaVvuLHONksAbzhrmAJxpoSgonGq4ZZxKa2kHCpRsl0vkgvELcnvgumjWepv8xqQ_Ohqv90JMD9qk0dsBte2d4o6iURYb2wi5FL0FpNCUUXTYFdaXA2s7LTfoLIax9PMC-vIl-JV-iDvdth1jXVMAn46AFH9PmEe98dmWcZiAccqaKl420jCuivXjf9Z1nFIoo9KMgxQdZVQWFxxcNsWcE_ZPn6GgHxOg9wnQjwnQ-wSUkg_Pm3gq-Ldy_hexVa3U
CitedBy_id crossref_primary_10_1177_0963689718815850
crossref_primary_10_3389_fnmol_2023_1229728
crossref_primary_10_1016_j_jchemneu_2022_102079
crossref_primary_10_1007_s12013_020_00936_z
crossref_primary_10_1155_2019_1036907
crossref_primary_10_3233_JAD_191112
crossref_primary_10_3389_fncel_2021_679034
crossref_primary_10_3389_fnins_2021_678454
crossref_primary_10_3390_brainsci10050286
crossref_primary_10_1152_ajpheart_00332_2022
crossref_primary_10_3389_fmed_2021_655123
crossref_primary_10_3389_fphar_2022_986668
crossref_primary_10_31857_S086981392307004X
crossref_primary_10_1128_jvi_00696_23
crossref_primary_10_3389_fnmol_2017_00383
crossref_primary_10_1016_j_bioactmat_2021_01_007
crossref_primary_10_1002_adhm_202304103
crossref_primary_10_1016_j_jpurol_2023_09_019
crossref_primary_10_12688_mniopenres_12816_1
crossref_primary_10_12688_mniopenres_12816_2
crossref_primary_10_3389_fendo_2024_1358311
crossref_primary_10_4103_1673_5374_382987
crossref_primary_10_3390_cells11132002
crossref_primary_10_3390_cells10113238
crossref_primary_10_1186_s13287_020_02049_z
crossref_primary_10_1186_s41232_023_00310_5
crossref_primary_10_3389_fcell_2021_661656
crossref_primary_10_3389_fpsyg_2022_814633
crossref_primary_10_1002_bab_1791
crossref_primary_10_1155_2022_9887985
crossref_primary_10_4103_1673_5374_354517
crossref_primary_10_3389_fpsyg_2020_01296
crossref_primary_10_1038_s41398_023_02366_w
crossref_primary_10_23946_2500_0764_2021_6_3_15_24
crossref_primary_10_1007_s13770_021_00330_7
crossref_primary_10_1016_j_ecoenv_2022_114223
crossref_primary_10_1039_C8CC09253B
crossref_primary_10_1089_jir_2021_0116
crossref_primary_10_1134_S0022093023040191
crossref_primary_10_1007_s11064_021_03266_5
crossref_primary_10_1016_j_jad_2022_09_025
Cites_doi 10.1006/exnr.1994.1091
10.1074/jbc.M107992200
10.1016/s0896-6273(02)00864-4
10.1016/s0925-4773(01)00385-9
10.1016/j.brainresbull.2004.10.012
10.1016/0006-8993(95)00369-2
10.1016/j.cellbi.2004.01.006
10.1016/j.expneurol.2014.08.002
10.1146/annurev.neuro.051508.135722
10.1523/JNEUROSCI.0808-14.2014
10.1007/s12576-015-0397-0
10.1016/j.neuroscience.2016.07.040
10.1371/journal.pone.0125034
10.1016/j.neuron.2012.08.021
10.1038/nn.4060
10.1016/s0169-328x(99)00015-7
10.1523/JNEUROSCI.5185-07.2008
10.1096/fj.15-278739
10.1006/exnr.1998.6715
10.1016/0306-4522(96)00045-0
10.1523/JNEUROSCI.14-01-00335.1994
10.1242/dev.126.12.2785
10.1053/j.gastro.2009.11.048
10.1016/j.brainres.2004.12.054
10.1016/j.neuron.2009.07.031
10.1523/JNEUROSCI.18-12-04684.1998
10.1038/sj.onc.1206980
10.1523/JNEUROSCI.3528-06.2006
10.1634/stemcells.22-5-669
10.1016/j.expneurol.2014.02.021
10.1038/sj.onc.1205226
10.1038/382080a0
10.1634/stemcells.2005-0409
10.1016/j.brainres.2007.04.071
10.1016/s0016-5085(03)00404-9
10.1016/j.tins.2008.05.003
10.1083/jcb.130.1.137
10.1016/j.brainres.2007.07.064
10.3389/fncel.2016.00217
10.1046/j.1460-9568.2000.00219.x
10.1007/s10571-014-0120-3
10.1002/lary.25953
10.1111/j.1460-9568.2008.06452.x
10.1016/j.nbd.2016.01.021
10.3109/08039488.2015.1014834
10.1016/j.pharmthera.2014.05.010
10.1038/nn.2637
10.1053/jpsu.2000.7763
10.1016/j.wneu.2013.01.042
10.2165/00007256-200333020-00005
10.1038/382076a0
10.1523/JNEUROSCI.0898-11.2011
10.1002/(SICI)1097-4547(19980815)53:4<405::AID-JNR2>3.0.CO;2-A
10.1016/j.yexcr.2004.03.037
10.1517/14728222.2016.1085972
10.1016/j.expneurol.2015.03.002
10.1002/jnr.10396
10.1016/j.mcn.2005.04.011
10.1523/JNEUROSCI.18-11-04106.1998
10.1038/srep32292
10.1016/s0304-3940(03)01539-8
10.1007/s00441-007-0538-8
10.1097/NEN.0b013e31822830e5
10.1016/j.ejpain.2009.05.016
10.1016/j.maturitas.2013.05.019
10.1016/s0306-4522(00)00326-2
10.2147/ijn.s96324
10.1016/0165-3806(94)00197-8
10.1523/JNEUROSCI.2582-13.2014
10.1101/gad.1257105
10.1007/s00787-016-0898-2
10.1016/j.expneurol.2007.01.014
10.3892/ijmm.2015.2438
10.5966/sctm.2013-0072
10.1038/382070a0
10.1006/dbio.1998.9090
10.1016/j.biochi.2013.08.004
10.1016/j.neuroscience.2009.03.006
10.1093/emboj/19.15.4056
10.1016/j.celrep.2016.01.067
10.3171/FOC.2009.26.2.E3
10.1016/j.aanat.2015.12.001
10.1016/j.neuroscience.2011.07.072
10.1002/ana.20737
10.1016/s0306-4522(98)00592-2
10.1242/jcs.167544
10.3389/fnana.2015.00043
10.1016/j.stem.2015.06.003
10.1038/mt.2011.11
10.1038/nature08797
10.1016/j.jad.2016.02.067
10.1016/j.ydbio.2012.08.002
10.1111/bph.13073
10.1038/tp.2015.11
10.1016/j.neuron.2006.02.020
10.1242/jcs.00786
10.1007/s12031-013-0224-0
10.1006/exnr.2001.7718
10.1038/382073a0
10.1523/JNEUROSCI.20-23-08754.2000
10.1523/JNEUROSCI.20-08-02917.2000
10.1146/annurev-neuro-062012-170354
10.1016/0925-4773(95)00464-5
10.1126/science.8493557
10.1016/j.cell.2006.10.042
10.1089/ten.TEA.2015.0311
10.1016/j.jpsychires.2015.02.004
10.1196/annals.1336.010
10.1016/j.neuroscience.2004.06.067
10.1002/jnr.20507
10.3389/fnana.2016.00073
10.1006/exnr.2001.7706
10.1042/CBI20090344
10.1002/jnr.22499
10.1126/science.7973664
10.1016/j.brainres.2016.01.051
10.1016/j.devbrainres.2004.07.006
10.1007/s004410100401
10.1016/j.pneurobio.2008.09.006
10.1016/j.bbapap.2012.10.008
10.1016/s0736-5748(99)00057-x
10.1038/nn734
ContentType Journal Article
Copyright 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2017 Cortés, Carballo-Molina, Castellanos-Montiel and Velasco. 2017 Cortés, Carballo-Molina, Castellanos-Montiel and Velasco
Copyright_xml – notice: 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2017 Cortés, Carballo-Molina, Castellanos-Montiel and Velasco. 2017 Cortés, Carballo-Molina, Castellanos-Montiel and Velasco
DBID NPM
AAYXX
CITATION
3V.
7TK
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3389/fnmol.2017.00258
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Neurosciences Abstracts
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Biological Sciences
ProQuest Science Journals
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
Open Access: DOAJ - Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Science Journals (Alumni Edition)
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Central Essentials
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1662-5099
EndPage 258
ExternalDocumentID oai_doaj_org_article_cfd93d1ea9ce4c468b6fc0e1048617e7
10_3389_fnmol_2017_00258
28878618
Genre Journal Article
Review
GeographicLocations Mexico
GeographicLocations_xml – name: Mexico
GrantInformation_xml – fundername: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
  grantid: IN213716
GroupedDBID ---
29H
2WC
53G
5GY
5VS
88I
8FE
8FH
9T4
AAFWJ
ABUWG
ACGFO
ACGFS
ACPRK
ACXDI
ADBBV
ADRAZ
AEGXH
AENEX
AFKRA
AFPKN
AIAGR
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
C1A
CCPQU
CS3
DIK
DWQXO
E3Z
EMOBN
F5P
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HYE
IAO
IEA
IHR
IPNFZ
KQ8
LK8
M2P
M48
M7P
M~E
NPM
O5R
O5S
OK1
PGMZT
PIMPY
PQQKQ
PROAC
RIG
RNS
RPM
TR2
AAYXX
CITATION
3V.
7TK
7XB
8FK
PQEST
PQUKI
PRINS
Q9U
7X8
ITC
5PM
ID FETCH-LOGICAL-c490t-6276ae30ea553dc2d4980343242d00da50d49e6d943c2318cc17090985bbe3623
IEDL.DBID RPM
ISSN 1662-5099
IngestDate Tue Oct 22 14:59:17 EDT 2024
Tue Sep 17 20:59:08 EDT 2024
Sat Aug 17 03:42:23 EDT 2024
Thu Oct 10 19:10:17 EDT 2024
Thu Sep 26 18:14:20 EDT 2024
Sat Sep 28 08:07:30 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords pain
glioblastoma
motor neuron
dopaminergic neurons
neuroblastoma
neurogenesis
enteric nervous system
electrophysiological maturation
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c490t-6276ae30ea553dc2d4980343242d00da50d49e6d943c2318cc17090985bbe3623
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Isabel Varela-Nieto, Consejo Superior de Investigaciones Científicas (CSIC), Spain
Reviewed by: Nicolas Caron, Affichem SA, France; Hong Qing, Beijing Institute of Technology, School of Life Science, China
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572274/
PMID 28878618
PQID 2308671218
PQPubID 2046457
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_cfd93d1ea9ce4c468b6fc0e1048617e7
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5572274
proquest_miscellaneous_1936624239
proquest_journals_2308671218
crossref_primary_10_3389_fnmol_2017_00258
pubmed_primary_28878618
PublicationCentury 2000
PublicationDate 2017-08-22
PublicationDateYYYYMMDD 2017-08-22
PublicationDate_xml – month: 08
  year: 2017
  text: 2017-08-22
  day: 22
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Lausanne
PublicationTitle Frontiers in molecular neuroscience
PublicationTitleAlternate Front Mol Neurosci
PublicationYear 2017
Publisher Frontiers Research Foundation
Frontiers Media S.A
Publisher_xml – name: Frontiers Research Foundation
– name: Frontiers Media S.A
References 22902531 - Dev Biol. 2012 Oct 15;370(2):250-63
25914629 - Front Neuroanat. 2015 Apr 10;9:43
9500954 - Exp Neurol. 1998 Feb;149(2):411-23
7790368 - J Cell Biol. 1995 Jul;130(1):137-48
21839809 - Neuroscience. 2011 Oct 27;194:220-6
26253201 - Cell Stem Cell. 2015 Aug 6;17 (2):195-203
8657308 - Nature. 1996 Jul 4;382(6586):76-9
11102483 - J Neurosci. 2000 Dec 1;20(23):8754-61
9710260 - J Neurosci Res. 1998 Aug 15;53(4):405-14
25301495 - Cell Mol Neurobiol. 2015 Mar;35(2):255-64
21343917 - Mol Ther. 2011 Jun;19(6):1048-57
27561780 - Eur Child Adolesc Psychiatry. 2017 Mar;26(3):355-363
12372284 - Neuron. 2002 Aug 29;35(5):893-905
20107439 - Nature. 2010 Feb 25;463(7284):1035-41
26709397 - Int J Mol Med. 2016 Feb;37(2):493-500
24399412 - J Mol Neurosci. 2014 Aug;53(4):580-9
21029049 - Cell Biol Int. 2011 Apr;35(4):325-34
8783257 - Neuroscience. 1996 Jul;73(2):397-406
25753832 - Nord J Psychiatry. 2015;69(7):546-51
17320866 - Exp Neurol. 2007 Apr;204(2):791-801
23994163 - Biochimie. 2013 Dec;95(12):2257-70
15212950 - Exp Cell Res. 2004 Jul 15;297(2):484-94
7973664 - Science. 1994 Nov 11;266(5187):1062-4
21865882 - J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47
26718890 - FASEB J. 2016 May;30(5):1696-711
15135891 - Neurosci Lett. 2004 May 6;361(1-3):52-5
7965061 - J Neurosci. 1994 Nov;14(11 Pt 1):6571-84
15655114 - Genes Dev. 2005 Jan 15;19(2):282-94
10917288 - J Pediatr Surg. 2000 Jul;35(7):1017-25
23827471 - Maturitas. 2013 Nov;76(3):272-8
15950488 - Mol Cell Neurosci. 2005 Aug;29(4):617-27
24089415 - Stem Cells Transl Med. 2013 Nov;2(11):906-15
15381279 - Neuroscience. 2004;128(3):497-509
26706106 - Ann Anat. 2016 Sep;207 :55-61
19755105 - Neuron. 2009 Sep 10;63(5):614-27
9614243 - J Neurosci. 1998 Jun 15;18(12):4684-96
16429411 - Ann Neurol. 2006 Mar;59(3):459-66
10095078 - Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):62-70
16822882 - Stem Cells. 2006 Jul;24(7):1695-706
25032496 - Annu Rev Neurosci. 2014;37:221-42
18305247 - J Neurosci. 2008 Feb 27;28(9):2131-46
27059613 - Laryngoscope. 2016 Oct;126(10 ):E337-42
8657307 - Nature. 1996 Jul 4;382(6586):73-6
8283241 - J Neurosci. 1994 Jan;14 (1):335-47
27558932 - Sci Rep. 2016 Aug 25;6:32292
11476598 - Exp Neurol. 2001 Aug;170(2):317-25
21900559 - J Neurosci. 2011 Sep 7;31(36):12802-15
18824211 - Prog Neurobiol. 2008 Nov;86(3):186-215
23334003 - World Neurosurg. 2015 Jan;83(1):120-31
22998873 - Neuron. 2012 Sep 20;75(6):1051-66
25632161 - J Cell Sci. 2015 Mar 15;128(6):1241-52
25253858 - J Neurosci. 2014 Sep 24;34(39):13127-38
16325003 - Brain Res Bull. 2005 Dec 15;68(1-2):42-53
10568685 - Int J Dev Neurosci. 1999 Nov;17(7):681-91
16600854 - Neuron. 2006 Apr 6;50(1):35-47
9592091 - J Neurosci. 1998 Jun 1;18(11):4106-18
11036204 - Neuroscience. 2000;100(4):701-12
20857516 - J Neurosci Res. 2010 Nov 15;88(15):3222-32
10331988 - Development. 1999 Jun;126(12):2785-97
9882478 - Dev Biol. 1998 Dec 15;204(2):385-406
15725414 - Brain Res. 2005 Mar 2;1036(1-2):163-72
27445711 - Front Neuroanat. 2016 Jun 24;10:73
8968339 - J Pharmacol Exp Ther. 1996 Dec;279(3):1181-90
12205689 - J Neurosci Res. 2002 Sep 15;69(6):955-65
16467260 - Ann N Y Acad Sci. 2005 Dec;1061:94-9
7781171 - Brain Res Dev Brain Res. 1995 Mar 16;85(1):80-8
25962165 - PLoS One. 2015 May 11;10(5):e0125034
10998101 - Eur J Neurosci. 2000 Sep;12(9):3172-80
15342931 - Stem Cells. 2004;22(5):669-74
18597864 - Trends Neurosci. 2008 Aug;31(8):384-91
26125271 - Eur Rev Med Pharmacol Sci. 2015;19(11):2070-5
25689572 - Transl Psychiatry. 2015 Feb 17;5:e511
26904955 - Cell Rep. 2016 Mar 1;14 (8):1901-15
26147533 - Nat Neurosci. 2015 Aug;18(8):1084-93
14712226 - Oncogene. 2004 Jan 8;23(1):213-25
10751444 - J Neurosci. 2000 Apr 15;20(8):2917-25
26466815 - Tissue Eng Part A. 2015 Dec;21(23-24):2852-64
24854598 - Pharmacol Ther. 2014 Nov;144(2):123-33
18973572 - Eur J Neurosci. 2008 Oct;28(8):1467-79
8493557 - Science. 1993 May 21;260(5111):1130-2
23085183 - Biochim Biophys Acta. 2013 Oct;1834(10):2205-12
17192424 - J Neurosci. 2006 Dec 27;26(52):13413-27
17190606 - Cell. 2006 Dec 29;127(7):1439-52
11896605 - Oncogene. 2002 Mar 7;21(11):1739-49
17574220 - Brain Res. 2007 Jul 23;1159:28-39
26854135 - Brain Res. 2016 Apr 1;1636:93-106
25726496 - J Psychiatr Res. 2015 Apr;63:20-7
12617692 - Sports Med. 2003;33(2):145-64
8657309 - Nature. 1996 Jul 4;382(6586):80-3
15880784 - J Neurosci Res. 2005 Jun 15;80(6):759-66
26829643 - Neurobiol Dis. 2017 Jan;97(Pt B):80-89
20835249 - Nat Neurosci. 2010 Oct;13(10):1233-9
27476437 - Neuroscience. 2016 Oct 15;334:93-104
19228105 - Neurosurg Focus. 2009 Feb;26(2):E3
18071753 - Cell Tissue Res. 2008 Feb;331(2):373-83
15109990 - Cell Biol Int. 2004;28(4):323-5
19596210 - Eur J Pain. 2010 Mar;14(3):255-60
26863504 - Expert Opin Ther Targets. 2016;20(2):193-208
24613827 - Exp Neurol. 2014 Dec;262 Pt B:127-37
11512671 - Cell Tissue Res. 2001 Jul;305(1):43-51
12953054 - J Cell Sci. 2003 Oct 1;116(Pt 19):3855-62
25297108 - J Neurosci. 2014 Oct 8;34(41):13819-33
8657306 - Nature. 1996 Jul 4;382(6586):70-3
12806607 - Gastroenterology. 2003 Jun;124(7):1748-57
27099497 - Int J Nanomedicine. 2016 Apr 01;11:1383-94
15464216 - Brain Res Dev Brain Res. 2004 Oct 15;153(1):39-51
26467448 - J Physiol Sci. 2016 Jan;66(1):43-52
25128265 - Exp Neurol. 2014 Nov;261:578-93
8033959 - Exp Neurol. 1994 Jun;127(2):167-70
11429285 - Mech Dev. 2001 Jul;105(1-2):93-104
19285119 - Neuroscience. 2009 Jun 16;161(1):148-56
11476604 - Exp Neurol. 2001 Aug;170(2):375-9
26956384 - J Affect Disord. 2016 Jun;197:9-20
19944698 - Gastroenterology. 2010 Apr;138(4):1491-501
27672361 - Front Cell Neurosci. 2016 Sep 12;10:217
11593232 - Nat Neurosci. 2001 Nov;4(11):1071-8
10199601 - Neuroscience. 1999 Mar;89(3):643-7
17825269 - Brain Res. 2007 Oct 10;1173:36-52
25572945 - Br J Pharmacol. 2015 May;172(10):2469-78
8808409 - Mech Dev. 1996 Jan;54(1):95-105
7552352 - Brain Res. 1995 Jun 19;683(2):172-8
11713247 - J Biol Chem. 2002 Jan 18;277(3):1991-9
10921886 - EMBO J. 2000 Aug 1;19(15):4056-63
20367447 - Annu Rev Neurosci. 2010;33:409-40
25771799 - Exp Neurol. 2015 May;267:165-76
Tarazi (B105) 2014; 144
Christophersen (B15) 2007; 204
Yang (B118) 2004; 128
Lei (B53) 2011; 70
Kanning (B44) 2010; 33
Saavedra (B85) 2008; 86
Steinkamp (B99) 2003; 124
Lin (B57) 2015; 63
Fletcher (B24) 2011; 194
Förander (B25) 2001; 305
Forostyak (B26) 2013; 95
Martucciello (B63) 2000; 35
Schmutzler (B92) 2009; 161
Salio (B87) 2014; 34
Schaller (B91) 2005; 1036
Buss (B7) 2006; 26
Kimura (B46) 2015; 172
Lee (B52) 2005; 19
Wood (B116) 2005; 80
Yang (B117) 2001; 4
Richardson (B81) 2011; 19
Storch (B100) 2001; 170
Kramer (B50) 2006; 50
Bordeaux (B4) 2000; 19
Choi-Lundberg (B14) 1995; 85
Taraviras (B104) 1999; 126
Zhu (B125) 2015; 35
Hantman (B34) 2010; 13
Wang (B113) 2016; 6
Thomsen (B107) 2014; 262
Engele (B22) 1996; 73
Merighi (B64) 2016; 20
Santos (B89) 2016; 1636
Hoyng (B39) 2014; 261
Chalazonitis (B11) 1994; 14
Quartu (B79) 2007; 1173
Gould (B31) 2008; 28
Zhu (B124) 2015; 18
Lin (B56) 1993; 260
Garbayo (B28) 2013; 76
Mizumura (B66) 2016; 66
Consales (B16) 2007; 1159
Ling (B58) 1998; 149
Greene (B32) 2014; 37
Ikeda (B43) 1999; 17
Kawamoto (B45) 2000; 100
Vrieseling (B112) 2006; 127
Cummins (B19) 2000; 20
Wang (B114) 2013; 1834
Bilgiç (B3) 2017; 26
Maheu (B59) 2015; 5
Yu (B120) 1998; 18
Trupp (B110) 1995; 130
Awad (B1) 2015; 83
Zahavi (B122) 2015; 128
Sun (B102) 2004; 28
Riaz (B80) 2004; 153
Roussa (B84) 2004; 361
Cheung (B13) 2003; 33
Miyazaki (B65) 1999; 89
Moore (B67) 1996; 382
Sanchez (B88) 1996; 382
Pothos (B76) 1998; 18
Pedersen (B72) 2010; 14
Catela (B9) 2016; 14
Li (B54) 2014; 53
Willand (B115) 2016; 334
Subramaniam (B101) 2008; 331
Pichel (B75) 1996; 382
Young (B119) 2010; 88
Engele (B21) 1998; 53
Li (B55) 2015; 17
Tannemaat (B103) 2008; 28
Ostenfeld (B69) 2002; 69
Forrest (B27) 2015; 9
Konishi (B49) 2014; 34
Behrman (B47) 2000
Haase (B33) 2002; 35
Yue (B121) 2006; 24
Shim (B94) 2015; 69
Zihlmann (B127) 2005; 68
Feng (B23) 1999; 66
Treanor (B109) 1996; 382
Qu (B78) 2015; 19
Vierbuchen (B111) 2010; 463
Doxakis (B20) 2005; 29
Zhuang (B126) 2016; 11
Baldassarre (B2) 2002; 21
Zeng (B123) 2010; 138
Salio (B86) 2016; 207
Pahnke (B70) 2004; 297
Charoy (B12) 2012; 75
Gordon (B30) 2009; 26
Mandai (B60) 2009; 63
Sharma (B93) 2016; 197
Stanga (B98) 2016; 30
Chalazonitis (B10) 1998; 204
Ortega-de San Luis (B68) 2016; 10
Peng (B73) 2011; 31
Springer (B97) 1994; 127
Qin (B77) 2016; 37
Marquardt (B61) 2015; 21
Sariola (B90) 2003; 116
Hellmich (B36) 1996; 54
Thang (B106) 2000; 20
Henderson (B37) 1994; 266
Braydich-Stolle (B6) 2005; 1061
Hernandez-Morato (B38) 2016; 126
Martin (B62) 1995; 683
Peterson (B74) 2004; 23
Rolletschek (B83) 2001; 105
Lang (B51) 2006; 59
Smith (B96) 2015; 267
Bourque (B5) 2000; 12
Kohno (B48) 2011; 35
Paratcha (B71) 2008; 31
Shimada (B95) 2012; 370
Coulpier (B18) 2002; 277
Garcia-Bennett (B29) 2013; 2
Ibáñez (B42) 2017; 97
Buytaert-Hoefen (B8) 2004; 22
Cortés (B17) 2016; 10
Hebert (B35) 1996; 279
Hyman (B40) 1994; 14
Rolan (B82) 2015; 10
Tolbert (B108) 2001; 170
References_xml – volume: 127
  start-page: 167
  year: 1994
  ident: B97
  article-title: Expression of GDNF mRNA in rat and human nervous tissue
  publication-title: Exp. Neurol.
  doi: 10.1006/exnr.1994.1091
  contributor:
    fullname: Springer
– volume: 277
  start-page: 1991
  year: 2002
  ident: B18
  article-title: Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M107992200
  contributor:
    fullname: Coulpier
– volume: 35
  start-page: 893
  year: 2002
  ident: B33
  article-title: GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
  publication-title: Neuron
  doi: 10.1016/s0896-6273(02)00864-4
  contributor:
    fullname: Haase
– volume: 105
  start-page: 93
  year: 2001
  ident: B83
  article-title: Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors
  publication-title: Mech. Dev.
  doi: 10.1016/s0925-4773(01)00385-9
  contributor:
    fullname: Rolletschek
– volume: 68
  start-page: 42
  year: 2005
  ident: B127
  article-title: The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons
  publication-title: Brain Res. Bull.
  doi: 10.1016/j.brainresbull.2004.10.012
  contributor:
    fullname: Zihlmann
– volume: 683
  start-page: 172
  year: 1995
  ident: B62
  article-title: Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(95)00369-2
  contributor:
    fullname: Martin
– volume: 28
  start-page: 323
  year: 2004
  ident: B102
  article-title: GDNF augments survival and differentiation of TH-positive neurons in neural progenitor cells
  publication-title: Cell Biol. Int.
  doi: 10.1016/j.cellbi.2004.01.006
  contributor:
    fullname: Sun
– volume: 261
  start-page: 578
  year: 2014
  ident: B39
  article-title: A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2014.08.002
  contributor:
    fullname: Hoyng
– volume: 33
  start-page: 409
  year: 2010
  ident: B44
  article-title: Motor neuron diversity in development and disease
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev.neuro.051508.135722
  contributor:
    fullname: Kanning
– volume: 34
  start-page: 13819
  year: 2014
  ident: B87
  article-title: Presynaptic modulation of spinal nociceptive transmission by glial cell line-derived neurotrophic factor (GDNF)
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0808-14.2014
  contributor:
    fullname: Salio
– volume: 66
  start-page: 43
  year: 2016
  ident: B66
  article-title: Delayed onset muscle soreness: involvement of neurotrophic factors
  publication-title: J. Physiol. Sci.
  doi: 10.1007/s12576-015-0397-0
  contributor:
    fullname: Mizumura
– volume: 334
  start-page: 93
  year: 2016
  ident: B115
  article-title: Electrical muscle stimulation elevates intramuscular BDNF and GDNF mRNA following peripheral nerve injury and repair in rats
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2016.07.040
  contributor:
    fullname: Willand
– volume: 10
  start-page: e0125034
  year: 2015
  ident: B82
  article-title: First-in-human, double-blind, placebo-controlled, randomized, dose-escalation study of BG00010, a glial cell line-derived neurotrophic factor family member, in subjects with unilateral sciatica
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0125034
  contributor:
    fullname: Rolan
– volume: 75
  start-page: 1051
  year: 2012
  ident: B12
  article-title: Gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.08.021
  contributor:
    fullname: Charoy
– volume: 18
  start-page: 1084
  year: 2015
  ident: B124
  article-title: Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4060
  contributor:
    fullname: Zhu
– volume: 66
  start-page: 62
  year: 1999
  ident: B23
  article-title: Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons
  publication-title: Mol. Brain Res.
  doi: 10.1016/s0169-328x(99)00015-7
  contributor:
    fullname: Feng
– volume: 28
  start-page: 2131
  year: 2008
  ident: B31
  article-title: The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5185-07.2008
  contributor:
    fullname: Gould
– volume: 30
  start-page: 1696
  year: 2016
  ident: B98
  article-title: APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation
  publication-title: FASEB J.
  doi: 10.1096/fj.15-278739
  contributor:
    fullname: Stanga
– volume: 149
  start-page: 411
  year: 1998
  ident: B58
  article-title: Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines
  publication-title: Exp. Neurol.
  doi: 10.1006/exnr.1998.6715
  contributor:
    fullname: Ling
– volume: 73
  start-page: 397
  year: 1996
  ident: B22
  article-title: Growth factor-induced c-fos expression defines distinct subsets of midbrain dopaminergic neurons
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(96)00045-0
  contributor:
    fullname: Engele
– volume: 14
  start-page: 335
  year: 1994
  ident: B40
  article-title: Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.14-01-00335.1994
  contributor:
    fullname: Hyman
– volume: 126
  start-page: 2785
  year: 1999
  ident: B104
  article-title: Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
  publication-title: Development
  doi: 10.1242/dev.126.12.2785
  contributor:
    fullname: Taraviras
– volume: 138
  start-page: 1491
  year: 2010
  ident: B123
  article-title: Glial cell-derived neurotrophic factor enhances synaptic communication and 5-hydroxytryptamine 3a receptor expression in enteric neurons
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2009.11.048
  contributor:
    fullname: Zeng
– volume: 1036
  start-page: 163
  year: 2005
  ident: B91
  article-title: Effect of GDNF on differentiation of cultured ventral mesencephalic dopaminergic and non-dopaminergic calretinin-expressing neurons
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2004.12.054
  contributor:
    fullname: Schaller
– volume: 63
  start-page: 614
  year: 2009
  ident: B60
  article-title: LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.07.031
  contributor:
    fullname: Mandai
– volume: 18
  start-page: 4684
  year: 1998
  ident: B120
  article-title: Expression of GDNF family receptor components during development: implications in the mechanisms of interaction
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-12-04684.1998
  contributor:
    fullname: Yu
– volume: 23
  start-page: 213
  year: 2004
  ident: B74
  article-title: The RET and TRKA pathways collaborate to regulate neuroblastoma differentiation
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206980
  contributor:
    fullname: Peterson
– volume: 26
  start-page: 13413
  year: 2006
  ident: B7
  article-title: Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3528-06.2006
  contributor:
    fullname: Buss
– volume: 22
  start-page: 669
  year: 2004
  ident: B8
  article-title: Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF
  publication-title: Stem Cells
  doi: 10.1634/stemcells.22-5-669
  contributor:
    fullname: Buytaert-Hoefen
– volume: 262
  start-page: 127
  year: 2014
  ident: B107
  article-title: The past, present and future of stem cell clinical trials for ALS
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2014.02.021
  contributor:
    fullname: Thomsen
– volume: 21
  start-page: 1739
  year: 2002
  ident: B2
  article-title: Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205226
  contributor:
    fullname: Baldassarre
– volume: 382
  start-page: 80
  year: 1996
  ident: B109
  article-title: Characterization of a multicomponent receptor for GDNF
  publication-title: Nature
  doi: 10.1038/382080a0
  contributor:
    fullname: Treanor
– volume: 24
  start-page: 1695
  year: 2006
  ident: B121
  article-title: Induction of midbrain dopaminergic neurons from primate embryonic stem cells by coculture with sertoli cells
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0409
  contributor:
    fullname: Yue
– volume: 1159
  start-page: 28
  year: 2007
  ident: B16
  article-title: GDNF signaling in embryonic midbrain neurons in vitro
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2007.04.071
  contributor:
    fullname: Consales
– volume: 124
  start-page: 1748
  year: 2003
  ident: B99
  article-title: Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells
  publication-title: Gastroenterology
  doi: 10.1016/s0016-5085(03)00404-9
  contributor:
    fullname: Steinkamp
– volume: 31
  start-page: 384
  year: 2008
  ident: B71
  article-title: GDNF and GFR alpha: a versatile molecular complex for developing neurons
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2008.05.003
  contributor:
    fullname: Paratcha
– volume: 130
  start-page: 137
  year: 1995
  ident: B110
  article-title: Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.130.1.137
  contributor:
    fullname: Trupp
– volume: 1173
  start-page: 36
  year: 2007
  ident: B79
  article-title: Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2007.07.064
  contributor:
    fullname: Quartu
– volume: 10
  start-page: 217
  year: 2016
  ident: B17
  article-title: Transgenic GDNF positively influences proliferation, differentiation, maturation and survival of motor neurons produced from mouse embryonic stem cells
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2016.00217
  contributor:
    fullname: Cortés
– volume: 19
  start-page: 2070
  year: 2015
  ident: B78
  article-title: Glial cell line-derived neurotrophic factor promotes proliferation of neuroglioma cells by up-regulation of cyclins PCNA and Ki-67
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  contributor:
    fullname: Qu
– volume: 12
  start-page: 3172
  year: 2000
  ident: B5
  article-title: GDNF enhances the synaptic efficacy of dopaminergic neurons in culture
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.2000.00219.x
  contributor:
    fullname: Bourque
– volume: 279
  start-page: 1181
  year: 1996
  ident: B35
  article-title: Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis
  publication-title: J. Pharmacol. Exp. Ther.
  contributor:
    fullname: Hebert
– volume: 35
  start-page: 255
  year: 2015
  ident: B125
  article-title: GDNF and NT-3 induce progenitor bone mesenchymal stem cell differentiation into neurons in fetal gut culture medium
  publication-title: Cell. Mol. Neurobiol.
  doi: 10.1007/s10571-014-0120-3
  contributor:
    fullname: Zhu
– volume: 126
  start-page: E337
  year: 2016
  ident: B38
  article-title: Blockade of glial-derived neurotrophic factor in laryngeal muscles promotes appropriate reinnervation
  publication-title: Laryngoscope
  doi: 10.1002/lary.25953
  contributor:
    fullname: Hernandez-Morato
– volume: 28
  start-page: 1467
  year: 2008
  ident: B103
  article-title: Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2008.06452.x
  contributor:
    fullname: Tannemaat
– volume: 97
  start-page: 80
  year: 2017
  ident: B42
  article-title: Biology of GDNF and its receptors—relevance for disorders of the central nervous system
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2016.01.021
  contributor:
    fullname: Ibáñez
– volume: 69
  start-page: 546
  year: 2015
  ident: B94
  article-title: Increased levels of plasma glial-derived neurotrophic factor in children with attention deficit hyperactivity disorder
  publication-title: Nord. J. Psychiatry
  doi: 10.3109/08039488.2015.1014834
  contributor:
    fullname: Shim
– volume: 144
  start-page: 123
  year: 2014
  ident: B105
  article-title: Emerging therapies for Parkinson’s disease: from bench to bedside
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2014.05.010
  contributor:
    fullname: Tarazi
– volume: 13
  start-page: 1233
  year: 2010
  ident: B34
  article-title: Clarke’s column neurons as the focus of a corticospinal corollary circuit
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2637
  contributor:
    fullname: Hantman
– volume: 35
  start-page: 1017
  year: 2000
  ident: B63
  article-title: Pathogenesis of Hirschsprung’s disease
  publication-title: J. Pediatr. Surg.
  doi: 10.1053/jpsu.2000.7763
  contributor:
    fullname: Martucciello
– volume: 83
  start-page: 120
  year: 2015
  ident: B1
  article-title: Potential role of growth factors in the management of spinal cord injury
  publication-title: World Neurosurg.
  doi: 10.1016/j.wneu.2013.01.042
  contributor:
    fullname: Awad
– volume: 33
  start-page: 145
  year: 2003
  ident: B13
  article-title: Delayed onset muscle soreness—treatment strategies and performance factors
  publication-title: Sports Med.
  doi: 10.2165/00007256-200333020-00005
  contributor:
    fullname: Cheung
– volume: 382
  start-page: 76
  year: 1996
  ident: B67
  article-title: Renal and neuronal abnormalities in mice lacking GDNF
  publication-title: Nature
  doi: 10.1038/382076a0
  contributor:
    fullname: Moore
– volume: 31
  start-page: 12802
  year: 2011
  ident: B73
  article-title: Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0898-11.2011
  contributor:
    fullname: Peng
– volume: 53
  start-page: 405
  year: 1998
  ident: B21
  article-title: Spatial and temporal growth factor influences on developing midbrain dopaminergic neurons
  publication-title: J. Neurosci. Res.
  doi: 10.1002/(SICI)1097-4547(19980815)53:4<405::AID-JNR2>3.0.CO;2-A
  contributor:
    fullname: Engele
– volume: 297
  start-page: 484
  year: 2004
  ident: B70
  article-title: Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2004.03.037
  contributor:
    fullname: Pahnke
– volume: 20
  start-page: 193
  year: 2016
  ident: B64
  article-title: Targeting the glial-derived neurotrophic factor and related molecules for controlling normal and pathologic pain
  publication-title: Expert Opin. Ther. Targets
  doi: 10.1517/14728222.2016.1085972
  contributor:
    fullname: Merighi
– volume: 267
  start-page: 165
  year: 2015
  ident: B96
  article-title: Increased brain bio-distribution and chemical stability and decreased immunogenicity of an engineered variant of GDNF
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2015.03.002
  contributor:
    fullname: Smith
– volume: 69
  start-page: 955
  year: 2002
  ident: B69
  article-title: Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.10396
  contributor:
    fullname: Ostenfeld
– volume: 29
  start-page: 617
  year: 2005
  ident: B20
  article-title: Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons
  publication-title: Mol. Cell. Neurosci.
  doi: 10.1016/j.mcn.2005.04.011
  contributor:
    fullname: Doxakis
– volume: 18
  start-page: 4106
  year: 1998
  ident: B76
  article-title: Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-11-04106.1998
  contributor:
    fullname: Pothos
– volume: 6
  start-page: 32292
  year: 2016
  ident: B113
  article-title: Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF
  publication-title: Sci. Rep.
  doi: 10.1038/srep32292
  contributor:
    fullname: Wang
– volume: 361
  start-page: 52
  year: 2004
  ident: B84
  article-title: GDNF promotes neuronal differentiation and dopaminergic development of mouse mesencephalic neurospheres
  publication-title: Neurosci. Lett.
  doi: 10.1016/s0304-3940(03)01539-8
  contributor:
    fullname: Roussa
– volume: 331
  start-page: 373
  year: 2008
  ident: B101
  article-title: GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-007-0538-8
  contributor:
    fullname: Subramaniam
– volume: 70
  start-page: 736
  year: 2011
  ident: B53
  article-title: Signaling of glial cell line-derived neurotrophic factor and its receptor GFRα1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/NEN.0b013e31822830e5
  contributor:
    fullname: Lei
– volume: 14
  start-page: 255
  year: 2010
  ident: B72
  article-title: Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1beta, GDNF and iNOS
  publication-title: Eur. J. Pain
  doi: 10.1016/j.ejpain.2009.05.016
  contributor:
    fullname: Pedersen
– volume: 76
  start-page: 272
  year: 2013
  ident: B28
  article-title: Drug development in Parkinson’s disease: from emerging molecules to innovative drug delivery systems
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2013.05.019
  contributor:
    fullname: Garbayo
– volume: 100
  start-page: 701
  year: 2000
  ident: B45
  article-title: Immunohistochemical localization of glial cell line-derived neurotrophic factor in the human central nervous system
  publication-title: Neuroscience
  doi: 10.1016/s0306-4522(00)00326-2
  contributor:
    fullname: Kawamoto
– volume: 11
  start-page: 1383
  year: 2016
  ident: B126
  article-title: Gelatin-methacrylamide gel loaded with microspheres to deliver GDNF in bilayer collagen conduit promoting sciatic nerve growth
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/ijn.s96324
  contributor:
    fullname: Zhuang
– volume: 85
  start-page: 80
  year: 1995
  ident: B14
  article-title: Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat
  publication-title: Dev. Brain Res.
  doi: 10.1016/0165-3806(94)00197-8
  contributor:
    fullname: Choi-Lundberg
– volume: 34
  start-page: 13127
  year: 2014
  ident: B49
  article-title: Deficiency of GDNF receptor GFRα1 in Alzheimer’s neurons results in neuronal death
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2582-13.2014
  contributor:
    fullname: Konishi
– volume: 19
  start-page: 282
  year: 2005
  ident: B52
  article-title: Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
  publication-title: Genes Dev.
  doi: 10.1101/gad.1257105
  contributor:
    fullname: Lee
– volume: 26
  start-page: 355
  year: 2017
  ident: B3
  article-title: Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder
  publication-title: Eur. Child Adolesc. Psychiatry
  doi: 10.1007/s00787-016-0898-2
  contributor:
    fullname: Bilgiç
– volume: 204
  start-page: 791
  year: 2007
  ident: B15
  article-title: Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2007.01.014
  contributor:
    fullname: Christophersen
– volume: 37
  start-page: 493
  year: 2016
  ident: B77
  article-title: Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2015.2438
  contributor:
    fullname: Qin
– volume: 2
  start-page: 906
  year: 2013
  ident: B29
  article-title: Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2013-0072
  contributor:
    fullname: Garcia-Bennett
– volume: 382
  start-page: 70
  year: 1996
  ident: B88
  article-title: Renal agenesis and the absence of enteric neurons in mice lacking GDNF
  publication-title: Nature
  doi: 10.1038/382070a0
  contributor:
    fullname: Sanchez
– volume: 204
  start-page: 385
  year: 1998
  ident: B10
  article-title: Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRα-1 in vitro and in vivo
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.1998.9090
  contributor:
    fullname: Chalazonitis
– volume: 95
  start-page: 2257
  year: 2013
  ident: B26
  article-title: The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2013.08.004
  contributor:
    fullname: Forostyak
– volume: 161
  start-page: 148
  year: 2009
  ident: B92
  article-title: Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2009.03.006
  contributor:
    fullname: Schmutzler
– volume: 19
  start-page: 4056
  year: 2000
  ident: B4
  article-title: The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease
  publication-title: EMBO J.
  doi: 10.1093/emboj/19.15.4056
  contributor:
    fullname: Bordeaux
– volume: 14
  start-page: 1901
  year: 2016
  ident: B9
  article-title: Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfrα genes
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.01.067
  contributor:
    fullname: Catela
– volume: 26
  start-page: E3
  year: 2009
  ident: B30
  article-title: The role of neurotrophic factors in nerve regeneration
  publication-title: Neurosurg. Focus
  doi: 10.3171/FOC.2009.26.2.E3
  contributor:
    fullname: Gordon
– volume: 207
  start-page: 55
  year: 2016
  ident: B86
  article-title: BDNF and GDNF expression in discrete populations of nociceptors
  publication-title: Ann. Anat.
  doi: 10.1016/j.aanat.2015.12.001
  contributor:
    fullname: Salio
– volume: 194
  start-page: 220
  year: 2011
  ident: B24
  article-title: Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2011.07.072
  contributor:
    fullname: Fletcher
– volume: 59
  start-page: 459
  year: 2006
  ident: B51
  article-title: Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.20737
  contributor:
    fullname: Lang
– volume: 89
  start-page: 643
  year: 1999
  ident: B65
  article-title: Glial cell line-derived neurotrophic factor protects against delayed neuronal death after transient forebrain ischemia in rats
  publication-title: Neuroscience
  doi: 10.1016/s0306-4522(98)00592-2
  contributor:
    fullname: Miyazaki
– volume: 128
  start-page: 1241
  year: 2015
  ident: B122
  article-title: A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.167544
  contributor:
    fullname: Zahavi
– volume: 9
  start-page: 43
  year: 2015
  ident: B27
  article-title: Peripheral injury of pelvic visceral sensory nerves alters GFRα (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord
  publication-title: Front. Neuroanat.
  doi: 10.3389/fnana.2015.00043
  contributor:
    fullname: Forrest
– volume: 17
  start-page: 195
  year: 2015
  ident: B55
  article-title: Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.06.003
  contributor:
    fullname: Li
– volume: 19
  start-page: 1048
  year: 2011
  ident: B81
  article-title: Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson’s disease
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2011.11
  contributor:
    fullname: Richardson
– volume: 463
  start-page: 1035
  year: 2010
  ident: B111
  article-title: Direct conversion of fibroblasts to functional neurons by defined factors
  publication-title: Nature
  doi: 10.1038/nature08797
  contributor:
    fullname: Vierbuchen
– volume: 197
  start-page: 9
  year: 2016
  ident: B93
  article-title: Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: a comprehensive review of human studies
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2016.02.067
  contributor:
    fullname: Sharma
– volume: 370
  start-page: 250
  year: 2012
  ident: B95
  article-title: Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor α1 (GFRα1) expression in the embryonic spinal cord
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2012.08.002
  contributor:
    fullname: Shimada
– volume-title: Nelson Textbook of Pediatrics.
  year: 2000
  ident: B47
  contributor:
    fullname: Behrman
– volume: 172
  start-page: 2469
  year: 2015
  ident: B46
  article-title: Glial cell line-derived neurotrophic factor-mediated enhancement of noradrenergic descending inhibition in the locus coeruleus exerts prolonged analgesia in neuropathic pain
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13073
  contributor:
    fullname: Kimura
– volume: 5
  start-page: e511
  year: 2015
  ident: B59
  article-title: MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2015.11
  contributor:
    fullname: Maheu
– volume: 50
  start-page: 35
  year: 2006
  ident: B50
  article-title: Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.02.020
  contributor:
    fullname: Kramer
– volume: 116
  start-page: 3855
  year: 2003
  ident: B90
  article-title: Novel functions and signalling pathways for GDNF
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.00786
  contributor:
    fullname: Sariola
– volume: 53
  start-page: 580
  year: 2014
  ident: B54
  article-title: NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations
  publication-title: J. Mol. Neurosci.
  doi: 10.1007/s12031-013-0224-0
  contributor:
    fullname: Li
– volume: 170
  start-page: 375
  year: 2001
  ident: B108
  article-title: Chronic intraventricular infusion of glial cell line-derived neurotrophic factor (GDNF) rescues some cerebellar Purkinje cells from heredodegeneration
  publication-title: Exp. Neurol.
  doi: 10.1006/exnr.2001.7718
  contributor:
    fullname: Tolbert
– volume: 382
  start-page: 73
  year: 1996
  ident: B75
  article-title: Defects in enteric innervation and kidney development in mice lacking GDNF
  publication-title: Nature
  doi: 10.1038/382073a0
  contributor:
    fullname: Pichel
– volume: 14
  start-page: 6571
  year: 1994
  ident: B11
  article-title: Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia
  publication-title: Development
  contributor:
    fullname: Chalazonitis
– volume: 20
  start-page: 8754
  year: 2000
  ident: B19
  article-title: Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-23-08754.2000
  contributor:
    fullname: Cummins
– volume: 20
  start-page: 2917
  year: 2000
  ident: B106
  article-title: Regulation of glial cell line-derived neurotrophic factor responsiveness in developing rat sympathetic neurons by retinoic acid and bone morphogenetic protein-2
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-08-02917.2000
  contributor:
    fullname: Thang
– volume: 37
  start-page: 221
  year: 2014
  ident: B32
  article-title: Neural tube defects
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-062012-170354
  contributor:
    fullname: Greene
– volume: 54
  start-page: 95
  year: 1996
  ident: B36
  article-title: Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
  publication-title: Mech. Dev.
  doi: 10.1016/0925-4773(95)00464-5
  contributor:
    fullname: Hellmich
– volume: 260
  start-page: 1130
  year: 1993
  ident: B56
  article-title: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
  publication-title: Science
  doi: 10.1126/science.8493557
  contributor:
    fullname: Lin
– volume: 127
  start-page: 1439
  year: 2006
  ident: B112
  article-title: Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3
  publication-title: Cell
  doi: 10.1016/j.cell.2006.10.042
  contributor:
    fullname: Vrieseling
– volume: 21
  start-page: 2852
  year: 2015
  ident: B61
  article-title: Finely tuned temporal and spatial delivery of GDNF promotes enhanced nerve regeneration in a long nerve defect model
  publication-title: Tissue Eng. Part A
  doi: 10.1089/ten.TEA.2015.0311
  contributor:
    fullname: Marquardt
– volume: 63
  start-page: 20
  year: 2015
  ident: B57
  article-title: Decreased glial cell line-derived neurotrophic factor levels in patients with depression: a meta-analytic study
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2015.02.004
  contributor:
    fullname: Lin
– volume: 1061
  start-page: 94
  year: 2005
  ident: B6
  article-title: Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate
  publication-title: Ann. N Y Acad. Sci.
  doi: 10.1196/annals.1336.010
  contributor:
    fullname: Braydich-Stolle
– volume: 128
  start-page: 497
  year: 2004
  ident: B118
  article-title: Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2004.06.067
  contributor:
    fullname: Yang
– volume: 80
  start-page: 759
  year: 2005
  ident: B116
  article-title: Differential effects of growth/differentiation factor 5 and glial cell line-derived neurotrophic factor on dopaminergic neurons and astroglia in cultures of embryonic rat midbrain
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.20507
  contributor:
    fullname: Wood
– volume: 10
  start-page: 73
  year: 2016
  ident: B68
  article-title: Simultaneous detection of both GDNF and GFRα1 expression patterns in the mouse central nervous system
  publication-title: Front. Neuroanat.
  doi: 10.3389/fnana.2016.00073
  contributor:
    fullname: Ortega-de San Luis
– volume: 170
  start-page: 317
  year: 2001
  ident: B100
  article-title: Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
  publication-title: Exp. Neurol.
  doi: 10.1006/exnr.2001.7706
  contributor:
    fullname: Storch
– volume: 35
  start-page: 325
  year: 2011
  ident: B48
  article-title: Establishment and characterization of a noradrenergic adrenal chromaffin cell line, tsAM5NE, immortalized with the temperature-sensitive SV40 T-antigen
  publication-title: Cell Biol. Int.
  doi: 10.1042/CBI20090344
  contributor:
    fullname: Kohno
– volume: 88
  start-page: 3222
  year: 2010
  ident: B119
  article-title: Glial cell line-derived neurotrophic factor enhances in vitro differentiation of mid-/hindbrain neural progenitor cells to dopaminergic-like neurons
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.22499
  contributor:
    fullname: Young
– volume: 266
  start-page: 1062
  year: 1994
  ident: B37
  article-title: GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
  publication-title: Science
  doi: 10.1126/science.7973664
  contributor:
    fullname: Henderson
– volume: 1636
  start-page: 93
  year: 2016
  ident: B89
  article-title: Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2016.01.051
  contributor:
    fullname: Santos
– volume: 153
  start-page: 39
  year: 2004
  ident: B80
  article-title: The differentiation potential of human foetal neuronal progenitor cells in vitro
  publication-title: Dev. Brain Res.
  doi: 10.1016/j.devbrainres.2004.07.006
  contributor:
    fullname: Riaz
– volume: 305
  start-page: 43
  year: 2001
  ident: B25
  article-title: Glial-cell-line-derived neurotrophic factor induces nerve fibre formation in primary cultures of adrenal chromaffin cells
  publication-title: Cell Tissue Res.
  doi: 10.1007/s004410100401
  contributor:
    fullname: Förander
– volume: 86
  start-page: 186
  year: 2008
  ident: B85
  article-title: Driving GDNF expression: the green and the red traffic lights
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2008.09.006
  contributor:
    fullname: Saavedra
– volume: 1834
  start-page: 2205
  year: 2013
  ident: B114
  article-title: Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbapap.2012.10.008
  contributor:
    fullname: Wang
– volume: 17
  start-page: 681
  year: 1999
  ident: B43
  article-title: Expression of glial cell line-derived neurotrophic factor in the brain and cerebrospinal fluid of the developing rat
  publication-title: Int. J. Dev. Neurosci.
  doi: 10.1016/s0736-5748(99)00057-x
  contributor:
    fullname: Ikeda
– volume: 4
  start-page: 1071
  year: 2001
  ident: B117
  article-title: GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn734
  contributor:
    fullname: Yang
SSID ssj0062653
Score 2.356055
SecondaryResourceType review_article
Snippet Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other...
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting factor for dopaminergic neurons. Afterwards, other cells...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 258
SubjectTerms Axonogenesis
Axons
Cell proliferation
Cell survival
Dopamine receptors
dopaminergic neurons
electrophysiological maturation
Enteric nervous system
Glial cell line-derived neurotrophic factor
Glioblastoma
Hydroxylase
motor neuron
Motor neurons
Nervous system
Neural stem cells
Neuroblastoma
neurogenesis
Neuronal-glial interactions
Neuroscience
Neurosciences
Nuclear receptors
Nurr1 protein
pain
Phenotypes
Stem cells
Survival factor
Tyrosine 3-monooxygenase
SummonAdditionalLinks – databaseName: Open Access: DOAJ - Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9UwDI_QDogLYuOrY5uCxIVDtDRN2uYIY48JabvAxG5Rk7japEc77b3H3z876Xt6DyFx4Zq0lWs7sR3HPzP2waCV6rU3AjpfC226IHwELVqQytuEgUbnkJdX9cW1_nZjbrZafdGdsAwPnBl3Gvpoq1hCZwPooOuWqlMklAQVVzaQ68hLsw6m8h6MXrqpclISQzB72g-_RsozlIRXqKi9-5YRSlj9f3Mw_7wnuWV4Zi_Y88lj5J8ypfvsCQwH7OnllBN_yX6ipPnVOIjvK1z2qDg8IxIv-Njzr3PUL34G8znHqBPEF1S43xB5wuRYPoz3t3eBz1LPHT4OaXh6fvGKXc_Of5xdiKldggjayqWoVVN3UEnojKliUFHbVlLdqFZRytgZiSNQR6urgF5dG0LZSCtta7wHtGPVa7Y3jAO8ZTxKL4MG3SujdNSUbKugRcvVWXR3vCzYxzX_3H1GxXAYTRCvXeK1I167xOuCfSYGb54jPOs0gFJ2k5Tdv6RcsKO1eNy0yBYOoydC50MnpWDvN9O4PCjn0Q0wrhYOCa-pBKayBXuTpbmhROEGi5_Ht5sdOe-Qujsz3N0mCG5jGoXx_OH_-Ld37Blxiw6qlTpie8uHFRyjp7P0J0mpHwFb4_wZ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgkxAviG8CAxmJFx6sOY6dxE-IjZUJaRUCJvZmJfZ1m1SS0rT8_dw5blkR4tV2otN922f_jrE3BqPUTLdGQNOWQpvGizaAFjVI1dqIgUbnkGfT8vRcf7owF-nAbUjXKjc-MTrq0Hs6Iz_EVJmg2DAivVv8FNQ1iqqrqYXGbbavck1l2v2jk-nnLxtfjNm6KcbiJG7F7OGs-9FTvSEn3EJFbd5vBKOI2f-vRPPv-5I3AtDkPruXMkf-fhT1A3YLuofszlmqjT9i31HifNp34usazR8ViI_IxAPvZ_zjHPWMH8N8znH3CeIDKt4vCDxic6yW_eLq2vNJ7L3D-y4Op_XDY3Y-Ofl2fCpS2wThtZUrUaqqbKCQ0BhTBK-CtrWk96NaBSlDYySOQBmsLjxmd7X3eSWttLVpW8B4Vjxhe13fwTPGg2yl16BnyigdNBXdCqgxgjUW055WZuzthn9uMaJjONxVEK9d5LUjXrvI64wdEYO36wjXOg70y0uXzMT5WbBFyKGxHrTXZU1vkSTkBAyYV1Bl7GAjHpeMbXB_VCNjr7fTaCZU-2g66NeDQ8JLegpT2Iw9HaW5pUSho8Xf49fVjpx3SN2d6a6vIhS3MZXCff3z_5P1gt0lPtBRtFIHbG-1XMNLzGVW7auksL8BBhb0CQ
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9QwDI5gkRAXxJvCgoLEhUMgzaNtDgjBwrBCmr3AiL1FbeLurjS0yzwQ_HvstDMwaMQ1jyr67MR2XH9h7LlFK9Waxgqom0IYWwfRRDCiAqkalzjQ6B5yelIcz8ynU3v6pzx6BHC5N7Sj96Rmi_nLn99_vcEN_5oiTrS3r9ruW09ZhJzYCJWtrrJrymhD-j4125wCeu5WD4nKvbN2DFPi79_ndP777-Rfxmhyi90cvUj-dhD7bXYFujvs-nTMk99lX1H6_KTvxOc1HgWoTHxgKV7yvuUf56hz_Ajmc46RKIj3qIQ_IPLE07Fa9JfnF4FP0js8vO9S8zh-eY_NJh--HB2L8QkFEYyTK1GosqhBS6it1TGoaFwlqZbUqChlrK3EFiiiMzqgp1eFkJfSSVfZpgG0bfo-O-j6Dh4yHmUjgwHTKqtMNJSA01ChNasdukCNzNiLDX7-cmDK8BhhENY-Ye0Ja5-wztg7Ang7jjiuU0O_OPPjlvGhjU7HHGoXwARTVFSXJCEnksC8hDJjhxvx-I3eeIyoiLEPHZeMPdt245ahPEjdQb9eelx4QWUx2mXswSDN7UoUHrr4eZxd7sh5Z6m7Pd3FeaLltrZUGOM_-v-yHrMbhANdSyt1yA5WizU8Qb9m1TxN6vobgGv2Ww
  priority: 102
  providerName: Scholars Portal
Title The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
URI https://www.ncbi.nlm.nih.gov/pubmed/28878618
https://www.proquest.com/docview/2308671218
https://search.proquest.com/docview/1936624239
https://pubmed.ncbi.nlm.nih.gov/PMC5572274
https://doaj.org/article/cfd93d1ea9ce4c468b6fc0e1048617e7
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDBbaDhh2Gfae1y7QgF12cCPrYVvHNWtaDEhQbCuWm2BLdBsgsYM89vtLyXbQDDvtooMkAwRJmaRIfSTks0IrVclSxVCUaSxVYePSgYxzYLzUAQPN30NOpun1rfw-U7Mjovq3MKFo35bz83qxPK_n96G2crW0w75ObHgzGSmVcYymhsfkOBOiD9Hb3y866Eq0-UiMvvSwqpeNTzEkHqqQK9-fj-PBylPf5uORKQqI_f9yM_-ulnxkfsYvyPPOb6RfW_pekiOoX5Gnky4z_pr8RnnTaVPHP3d4-FF9aItLvKFNRa8WqGV0BIsFxdgT4m-odn_A0YDMsV03q_u5pePQeYc2dZju9m_ekNvx5a_Rddw1TYit1GwbpzxLCxAMCqWEs9xJnTP_elRyx5grFMMZSJ2WwqJvl1ubZEwznauyBLRm4i05qZsa3hPqWMmsBFlxxaWTPuUmIEf7VWh0ekoWkS89_8yqxcYwGFN4tpvAduPZbgLbI3LhGbzf51Gtw0SzvjOdbI2tnBYugUJbkFamuX-JxCDxsIBJBllEznrxmO6obQzGUB6jD12ViHzaL-Mh8ZmPooZmtzFIeOofwggdkXetNPeU9NoQkexAzgekHq6gXgYg7k4PP_z3l6fkmWeRv6Pm_IycbNc7-IhOzrYckCcXl9ObH4NwSYDj1SzBcSLzQVD3BzeMAB8
link.rule.ids 230,315,733,786,790,870,891,2115,21416,24346,27955,27956,33777,33778,43838,53825,53827,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFLegk4AL4pvAACNx4WDNcewkPiE2VgqsFYJN7GYltsMmlaQ0LX8_7zluWRHiajvR0_u2n_17hLxSEKUaWSvmqzpnUlWW1c5LVnouah0w0PAccjrLJ2fy47k6jwdufbxWufGJwVG7zuIZ-QGkygjFBhHpzeInw65RWF2NLTSukz2E3CxHZO_wePb5y8YXQ7ausqE4CVsxfdC0PzqsN6SIWyiwzfuVYBQw-_-VaP59X_JKABrfIbdj5kjfDqK-S6759h65MY218fvkG0iczrqWfV2D-YMC0QGZuKddQ9_PQc_okZ_PKew-PXsHivfLOxqwOVbLbnFxaek49N6hXRuG4_r-ATkbH58eTVhsm8Cs1HzFclHklc-4r5TKnBVO6pLj-1EpHOeuUhxGfO60zCxkd6W1acE116Wqaw_xLHtIRm3X-seEOl5zK71shBLSSSy6Zb6ECFZpSHtqnpDXG_6ZxYCOYWBXgbw2gdcGeW0CrxNyiAzerkNc6zDQLb-baCbGNk5nLvWVtl5amZf4Fon7FIEB08IXCdnfiMdEY-vNH9VIyMvtNJgJ1j6q1nfr3gDhOT6FyXRCHg3S3FIiwNHC7-HrYkfOO6TuzrSXFwGKW6lCwL7-yf_JekFuTk6nJ-bkw-zTU3ILeYLH0kLsk9FqufbPIK9Z1c-j8v4Gt4n2_w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELaglSouiDeBAkbiwiFar2Mn8QnRx1IeXVVARW9WYk9opSVZNrv8fmYc79JFiKvtRNbMeB6e8TeMvdJopRpV6xSqOk-Vrlxae1BpCULWJmCg0T3k6TQ_OVcfLvRFrH_qY1nlWicGRe07R3fkI3SVCYoNLdKoiWURZ0eTN_OfKXWQokxrbKdxk-0WKtcYiO0eHE_PPq_1MnruOhsSlRiWmVHT_ugo9zAmDENJLd-vGaaA3_8vp_Pv2slrxmhyh92OXiR_O7D9LrsB7T22dxrz5PfZN-Q-n3Zt-mWFqgCFiQ8oxT3vGv5uhjLHD2E24xiJQnqEQvgLPA84HctFN7-8cnwS-vDwrg3DcX3_gJ1Pjr8enqSxhULqlBHLNJdFXkEmoNI68056ZUpBb0mV9EL4SgscgdwblTn09ErnxoUwwpS6rgFtW_aQ7bRdC48Z96IWToFqpJbKK0rAZVCiNasMukC1SNjrNf3sfEDKsBhhEK1toLUlWttA64QdEIE36wjjOgx0i-82HhnrGm8yP4bKOFBO5SW9SxIwJpDAcQFFwvbX7LHx4PX2j5gk7OVmGo8M5UGqFrpVb3HjOT2LyUzCHg3c3OxEotLF3-PXxRaft7a6PdNeXQZYbq0LiTH-k_9v6wXbQ7m1n95PPz5lt4gkdEMt5T7bWS5W8AxdnGX9PMrubz2X-zM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Non-Survival+Effects+of+Glial+Cell+Line-Derived+Neurotrophic+Factor+on+Neural+Cells&rft.jtitle=Frontiers+in+molecular+neuroscience&rft.au=Cort%C3%A9s%2C+Daniel&rft.au=Carballo-Molina%2C+Oscar+A&rft.au=Castellanos-Montiel%2C+Mar%C3%ADa+Jos%C3%A9&rft.au=Velasco%2C+Iv%C3%A1n&rft.date=2017-08-22&rft.pub=Frontiers+Research+Foundation&rft.eissn=1662-5099&rft_id=info:doi/10.3389%2Ffnmol.2017.00258&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-5099&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-5099&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-5099&client=summon