The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such a...
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Published in | Frontiers in molecular neuroscience Vol. 10; p. 258 |
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Abstract | Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions. |
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AbstractList | Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions. Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting factor for dopaminergic neurons. Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a factor supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase, Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons, GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions. |
Author | Velasco, Iván Carballo-Molina, Oscar A Castellanos-Montiel, María José Cortés, Daniel |
AuthorAffiliation | 1 Instituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de México México City, Mexico 2 Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y Neurología México City, Mexico |
AuthorAffiliation_xml | – name: 2 Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y Neurología México City, Mexico – name: 1 Instituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de México México City, Mexico |
Author_xml | – sequence: 1 givenname: Daniel surname: Cortés fullname: Cortés, Daniel organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico – sequence: 2 givenname: Oscar A surname: Carballo-Molina fullname: Carballo-Molina, Oscar A organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico – sequence: 3 givenname: María José surname: Castellanos-Montiel fullname: Castellanos-Montiel, María José organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico – sequence: 4 givenname: Iván surname: Velasco fullname: Velasco, Iván organization: Laboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, Mexico |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28878618$$D View this record in MEDLINE/PubMed |
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Keywords | pain glioblastoma motor neuron dopaminergic neurons neuroblastoma neurogenesis enteric nervous system electrophysiological maturation |
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SubjectTerms | Axonogenesis Axons Cell proliferation Cell survival Dopamine receptors dopaminergic neurons electrophysiological maturation Enteric nervous system Glial cell line-derived neurotrophic factor Glioblastoma Hydroxylase motor neuron Motor neurons Nervous system Neural stem cells Neuroblastoma neurogenesis Neuronal-glial interactions Neuroscience Neurosciences Nuclear receptors Nurr1 protein pain Phenotypes Stem cells Survival factor Tyrosine 3-monooxygenase |
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Title | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
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