The Use of Hydroxyapatite Loaded with Doxycycline (HADOX) in Dentoalveolar Surgery as a Risk-Reduction Therapeutic Protocol in Subjects Treated with Different Bisphosphonate Dosages

• Published in: Medicina (Kaunas, Lithuania) Vol. 59; no. 1; p. 46
• Main Authors: Sacco, Roberto, Sartoretto, Suelen Cristina, de Brito Resende, Rodrigo Figueiredo, de Albuquerque Calasans-Maia, Jose, Rossi, Alexandre Malta, de Souza Lima, Victor Hugo, de Almeida Barros Mourão, Carlos Fernando, Granjeiro, Jose Mauro, Yates, Julian, Calasans-Maia, Monica Diuana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.12.2022; MDPI
• Subjects: Acids; Acne; Animals; Antibiotics; Apoptosis; bisphosphonate; Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy; Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology; Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control; Bisphosphonates; Bone Density Conservation Agents - therapeutic use; Diphosphonates - adverse effects; doxycycline; Doxycycline - therapeutic use; Drug dosages; drug-delivery system; Enzymes; Hydroxyapatite; Hydroxyapatites; Inflammation; Laboratory animals; MRONJ; Rats; Risk Reduction Behavior; Spectrum analysis; Surgery; Zoledronic Acid - therapeutic use; bisphosphonate; hydroxyapatite; doxycycline; MRONJ; drug-delivery system

Medication-related osteonecrosis of the jaw (MRONJ) is considered as a severe adverse side effect of specific drugs such as anti-resorptive and anti-angiogenic medications. Evidence suggests that MRONJ is linked to invasive dental procedures, mainly dentoalveolar surgery. Several preventive strategi...