Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin

We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in...

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Bibliographic Details
Published inCell Vol. 93; no. 5; pp. 863 - 873
Main Authors Vainberg, Irina E, Lewis, Sally A, Rommelaere, Heidi, Ampe, Christophe, Vandekerckhove, Joel, Klein, Hannah L, Cowan, Nicholas J
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 29.05.1998
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