Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin

• Published in: Cell Vol. 93; no. 5; pp. 863 - 873
• Main Authors: Vainberg, Irina E, Lewis, Sally A, Rommelaere, Heidi, Ampe, Christophe, Vandekerckhove, Joel, Klein, Hannah L, Cowan, Nicholas J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.05.1998
• Subjects: Actins - metabolism; Amino Acid Sequence; Animals; Archaea - genetics; Biological Transport; Chaperonin 60 - metabolism; Chaperonin Containing TCP-1; Chaperonins - metabolism; Eukaryotic Cells; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Molecular Sequence Data; Protein Binding; Protein Denaturation; Protein Folding; Rabbits; Saccharomyces cerevisiae; Sequence Homology, Amino Acid

We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in...