Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex

• Published in: Frontiers in behavioral neuroscience Vol. 7; p. 150
• Main Authors: Reis, David S., Jarome, Timothy J., Helmstetter, Fred J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2013; Frontiers Media S.A
• Subjects: Amygdala; Animal memory; Anisomycin; Auditory plasticity; Enzymes; Fear conditioning; Kinases; Lactacystin; Memory; Neuroscience; Prefrontal Cortex; Proteasome inhibitors; Proteasomes; Protein biosynthesis; Protein degradation; Protein synthesis; Protein Synthesis Inhibitors; Proteins; Synaptic plasticity; trace conditioning; Transcription; Translation; Ubiquitin; fear conditioning; memory; trace conditioning; protein synthesis inhibitors; prefrontal cortex; protein degradation; ubiquitin

The cellular mechanisms supporting plasticity during memory consolidation have been a subject of considerable interest. De novo protein and mRNA synthesis in several brain areas are critical, and more recently protein degradation, mediated by the ubiquitin-proteasome system (UPS), has been shown to...