Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury

• Published in: Journal of hepatology Vol. 47; no. 1; pp. 128 - 134
• Main Authors: Huang, Yi-Shin, Su, Wei-Juin, Huang, Yi-Hsiang, Chen, Chih-Yen, Chang, Full-Young, Lin, Han-Chieh, Lee, Shou-Dong
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.07.2007; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Antitubercular Agents - toxicity; Bacterial diseases; Biological and medical sciences; Chemical and Drug Induced Liver Injury - genetics; Drug metabolizing enzyme; Drug toxicity and drugs side effects treatment; Drug-induced liver injury; Drug-Related Side Effects and Adverse Reactions; Female; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Genetic polymorphism; Genetic Predisposition to Disease; Glutathione S-transferase; Glutathione Transferase - genetics; Human bacterial diseases; Humans; Infectious diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Manganese superoxide dismutase; Medical sciences; Middle Aged; Mutation; NAD(P)H Dehydrogenase (Quinone) - genetics; NAD(P)H:quinone oxidoreductase; Other diseases. Semiology; Pharmacology. Drug treatments; Polymorphism, Genetic; Superoxide Dismutase - genetics; Toxic hepatitis; Toxicity: digestive system; Tuberculosis and atypical mycobacterial infections; Drug metabolizing enzyme; Genetic polymorphism; Drug-induced liver injury; Toxic hepatitis; Glutathione S-transferase; Manganese superoxide dismutase; NAD(P)H:quinone oxidoreductase; Enzyme; Transferases; Hepatic disease; Superoxide dismutase; Mycobacterial infection; Infection; Hepatitis; Tuberculosis; Glutathione transferase; Drug- induced liver injury; Bacteriosis; Digestive diseases; Genetics; Oxidoreductases; Hepatotoxicity; Manganese; Polymorphism

Drug metabolizing enzymes may be related to drug-induced liver injury (DILI). Manganese superoxide dismutase (MnSOD), NAD(P)H:quinone oxidoreductase (NQO1), and glutathione S-transferase (GST) are important drug metabolizing enzymes. We aimed to elucidate the relationship between genetic polymorphis...