Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function

• Published in: Frontiers in cellular neuroscience Vol. 11; p. 11
• Main Authors: Taylor, Anna M, Saifetiarova, Julia, Bhat, Manzoor A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 03.02.2017; Frontiers Media S.A
• Subjects: Amino acids; Axons; Cell adhesion & migration; Cell surface; Conduction; Glial cells; Immunoglobulins; Microscopy; Nervous system; Neurodegeneration; Neuronal-glial interactions; Neuroscience; Nodes of Ranvier; Potassium; Proteins; Sodium channels (voltage-gated); myelin; paranodes; neurofascin; axonal degeneration; nodes

Intricate molecular interactions between neurons and glial cells underlie the creation of unique domains that are essential for saltatory conduction of action potentials by myelinated axons. Previously, the cell surface adhesion molecule Neurofascin (Nfasc) has been shown to have a dual-role in the...