Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function
Intricate molecular interactions between neurons and glial cells underlie the creation of unique domains that are essential for saltatory conduction of action potentials by myelinated axons. Previously, the cell surface adhesion molecule Neurofascin (Nfasc) has been shown to have a dual-role in the...
Saved in:
Published in | Frontiers in cellular neuroscience Vol. 11; p. 11 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
03.02.2017
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Intricate molecular interactions between neurons and glial cells underlie the creation of unique domains that are essential for saltatory conduction of action potentials by myelinated axons. Previously, the cell surface adhesion molecule Neurofascin (Nfasc) has been shown to have a dual-role in the establishment of axonal domains from both the glial and neuronal interface. While the neuron-specific isoform of Neurofascin (NF186) is indispensable for clustering of voltage-gated sodium channels at nodes of Ranvier; the glial-specific isoform of Neurofascin (NF155) is required for myelinating glial cells to organize the paranodal domain. Although many studies have addressed the individual roles of NF155 and NF186 in assembling paranodes and nodes, respectively; critical questions about their roles in the maintenance and long-term health of the myelinated axons remain, which we aimed to address in these studies. Here using spatiotemporal ablation of Neurofascin in neurons alone or together with myelinating glia, we report that loss of NF186 individually from postnatal mice leads to progressive nodal destabilization and axonal degeneration. While individual ablation of paranodal NF155 does not disrupt nodes of Ranvier; loss of NF186 combined with NF155 causes more accelerated nodal destabilization than loss of NF186 alone, providing strong evidence regarding a supporting role for paranodes in nodal maintenance. In both cases of NF186 loss, myelinating axons show ultrastructural changes and degeneration. Our studies reveal that long-term maintenance of nodes and ultimately the health of axons is correlated with the stability of NF186 within the nodal complex and the presence of auxiliary paranodes. |
---|---|
AbstractList | Intricate molecular interactions between neurons and glial cells underlie the creation of unique domains that are essential for saltatory conduction of action potentials by myelinated axons. Previously, the cell surface adhesion molecule Neurofascin (Nfasc) has been shown to have a dual-role in the establishment of axonal domains from both the glial and neuronal interface. While the neuron-specific isoform of Neurofascin (NF186) is indispensable for clustering of voltage-gated sodium channels at nodes of Ranvier; the glial-specific isoform of Neurofascin (NF155) is required for myelinating glial cells to organize the paranodal domain. Although many studies have addressed the individual roles of NF155 and NF186 in assembling paranodes and nodes, respectively; critical questions about their roles in the maintenance and long-term health of the myelinated axons remain, which we aimed to address in these studies. Here using spatiotemporal ablation of Neurofascin in neurons alone or together with myelinating glia, we report that loss of NF186 individually from postnatal mice leads to progressive nodal destabilization and axonal degeneration. While individual ablation of paranodal NF155 does not disrupt nodes of Ranvier; loss of NF186 combined with NF155 causes more accelerated nodal destabilization than loss of NF186 alone, providing strong evidence regarding a supporting role for paranodes in nodal maintenance. In both cases of NF186 loss, myelinating axons show ultrastructural changes and degeneration. Our studies reveal that long-term maintenance of nodes and ultimately the health of axons is correlated with the stability of NF186 within the nodal complex and the presence of auxiliary paranodes. |
Author | Bhat, Manzoor A Taylor, Anna M Saifetiarova, Julia |
AuthorAffiliation | Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine, University of Texas Health Science Center San Antonio, TX, USA |
AuthorAffiliation_xml | – name: Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine, University of Texas Health Science Center San Antonio, TX, USA |
Author_xml | – sequence: 1 givenname: Anna M surname: Taylor fullname: Taylor, Anna M organization: Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine, University of Texas Health Science Center San Antonio, TX, USA – sequence: 2 givenname: Julia surname: Saifetiarova fullname: Saifetiarova, Julia organization: Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine, University of Texas Health Science Center San Antonio, TX, USA – sequence: 3 givenname: Manzoor A surname: Bhat fullname: Bhat, Manzoor A organization: Department of Cellular and Integrative Physiology, Center for Biomedical Neuroscience, School of Medicine, University of Texas Health Science Center San Antonio, TX, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28217083$$D View this record in MEDLINE/PubMed |
BookMark | eNpdUU1vFDEMjVAR_YA7JxSJC5ddHGd2krkgrVraIm0LQnCO0owDqWaTksxU7JF_3uy2VIVTHPv52X7vkO3FFImx1wLmUuruvY-OhjmCUHMAEOIZOxBti7OFANx7Eu-zw1KuAVpsG_2C7aNGoUDLA_bnSypjtKMd-CqVwpPnlzTlFGvCxp6fDaFGu5S3xYVY-EnwnjLFsVaGDV_WnxsLv0w9bdu_2ngbKPMLG-JI0dYVd0wXGxpCnUQ9X_5OkZ9O0Y0hxZfsubdDoVcP7xH7fvrx2_H5bPX57NPxcjVzTQfjrFlo65yS3oEAkB1p6pRvyaH24kr11HtQBGg71SA1WiA2hKrtReMUCiuP2Id73pvpak29qwdkO5ibHNY2b0yywfxbieGn-ZFuzQJ112msBO8eCHL6NVEZzTqUqv9gI6WpGKEVtE2rsavQt_9Br9OUq6bFIGohhVSdqCi4R7lcpc_kH5cRYLb-mp2_Zuuv2flbW948PeKx4a-h8g5xvaWP |
CitedBy_id | crossref_primary_10_1002_acn3_51775 crossref_primary_10_1002_glia_23665 crossref_primary_10_1523_ENEURO_0138_18_2018 crossref_primary_10_1002_jnr_24052 crossref_primary_10_1002_jnr_24352 crossref_primary_10_1016_j_ebiom_2018_08_004 crossref_primary_10_1172_JCI124694 crossref_primary_10_1523_JNEUROSCI_2095_18_2018 crossref_primary_10_1007_s10072_021_05220_3 crossref_primary_10_1083_jcb_201702150 crossref_primary_10_1093_brain_awy134 crossref_primary_10_3389_fnmol_2021_779385 crossref_primary_10_1093_brain_awac418 crossref_primary_10_1016_j_celrep_2023_113274 crossref_primary_10_1016_j_neurobiolaging_2020_04_017 crossref_primary_10_1172_JCI158524 crossref_primary_10_1111_jnc_14553 crossref_primary_10_1016_j_conb_2018_08_007 crossref_primary_10_3389_fncel_2018_00201 |
Cites_doi | 10.1523/JNEUROSCI.18-05-01642.1998 10.1002/jnr.22015 10.1084/jem.20071053 10.1523/JNEUROSCI.4662-13.2014 10.1016/j.neuron.2005.10.019 10.1371/journal.pone.0100834 10.1159/000132151 10.1038/nn.2118 10.1002/gene.10154 10.1523/JNEUROSCI.17-18-07025.1997 10.1016/j.neulet.2010.07.076 10.1177/1352458511434370 10.1093/brain/awl144 10.1016/j.neuron.2013.03.005 10.1016/S0896-6273(01)00294-X 10.1007/400_2009_3 10.4161/cc.28401 10.1523/JNEUROSCI.18-01-00036.1998 10.1523/JNEUROSCI.22-05-01726.2002 10.1111/j.1529-8027.2012.00372.x 10.3791/51181 10.1083/jcb.200712154 10.1016/S0896-6273(01)00306-3 10.1016/S0896-6273(01)00265-3 10.1038/nn.3859 10.1073/pnas.0601082103 10.1212/WNL.0b013e31827689ad 10.1016/S0165-0270(96)00121-5 10.1073/pnas.0402765101 10.1016/j.neuron.2011.10.016 10.1016/j.ydbio.2007.08.045 10.1016/j.neuron.2011.02.021 10.1006/dbio.2002.0597 10.1002/dvg.20777 10.1016/j.neuron.2010.12.016 10.1002/jnr.23197 10.1186/1471-2202-14-96 |
ContentType | Journal Article |
Copyright | 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2017 Taylor, Saifetiarova and Bhat. 2017 Taylor, Saifetiarova and Bhat |
Copyright_xml | – notice: 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2017 Taylor, Saifetiarova and Bhat. 2017 Taylor, Saifetiarova and Bhat |
DBID | NPM AAYXX CITATION 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
DOI | 10.3389/fncel.2017.00011 |
DatabaseName | PubMed CrossRef ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection Biological Sciences ProQuest Science Journals Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Science Journals (Alumni Edition) ProQuest Central Student ProQuest Biological Science Collection ProQuest Central Basic ProQuest Central Essentials ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | PubMed Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1662-5102 |
EndPage | 11 |
ExternalDocumentID | 10_3389_fncel_2017_00011 28217083 |
Genre | Journal Article |
GrantInformation_xml | – fundername: National Institute of Neurological Disorders and Stroke – fundername: National Institutes of Health – fundername: National Multiple Sclerosis Society – fundername: National Institute of General Medical Sciences |
GroupedDBID | --- 29H 2WC 53G 5GY 5VS 88I 8FE 8FH 9T4 AAFWJ ABUWG ACGFO ACGFS ACXDI ADBBV ADRAZ AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ C1A CCPQU CS3 DIK DWQXO E3Z EMOBN F5P GNUQQ GROUPED_DOAJ GX1 HCIFZ HYE IAO IEA IHR IHW IPNFZ ISR KQ8 LK8 M2P M48 M7P M~E NPM O5R O5S OK1 PGMZT PIMPY PQQKQ PROAC RIG RNS RPM TR2 AAYXX CITATION 3V. 7XB 8FK PQEST PQUKI PRINS Q9U 7X8 5PM |
ID | FETCH-LOGICAL-c490t-458acc73fc010039e8e97f6ec28f1b7dedf07e02a9742e481224e276d14c721a3 |
IEDL.DBID | RPM |
ISSN | 1662-5102 |
IngestDate | Tue Sep 17 21:06:03 EDT 2024 Fri Oct 25 04:22:53 EDT 2024 Thu Oct 10 20:17:52 EDT 2024 Thu Sep 26 19:38:15 EDT 2024 Sat Sep 28 08:09:51 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | myelin paranodes neurofascin axonal degeneration nodes |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c490t-458acc73fc010039e8e97f6ec28f1b7dedf07e02a9742e481224e276d14c721a3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Hansen Wang, University of Toronto, Canada Reviewed by: Åsa Fex-Svenningsen, University of Southern Denmark, Denmark; Kim A. Staats, University of Southern California, USA; Alexander Gow, Wayne State University School of Medicine, USA |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289982/ |
PMID | 28217083 |
PQID | 2281313791 |
PQPubID | 4424410 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5289982 proquest_miscellaneous_1870646829 proquest_journals_2281313791 crossref_primary_10_3389_fncel_2017_00011 pubmed_primary_28217083 |
PublicationCentury | 2000 |
PublicationDate | 2017-02-03 |
PublicationDateYYYYMMDD | 2017-02-03 |
PublicationDate_xml | – month: 02 year: 2017 text: 2017-02-03 day: 03 |
PublicationDecade | 2010 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland – name: Lausanne |
PublicationTitle | Frontiers in cellular neuroscience |
PublicationTitleAlternate | Front Cell Neurosci |
PublicationYear | 2017 |
Publisher | Frontiers Research Foundation Frontiers Media S.A |
Publisher_xml | – name: Frontiers Research Foundation – name: Frontiers Media S.A |
References | 16551741 - Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5137-42 21382554 - Neuron. 2011 Mar 10;69(5):945-56 21671347 - Genesis. 2011 Dec;49(12):942-9 17936266 - Dev Biol. 2007 Nov 15;311(2):408-22 18454144 - Nat Neurosci. 2008 Jun;11(6):721-8 9278538 - J Neurosci. 1997 Sep 15;17(18):7025-36 21262464 - Neuron. 2011 Jan 27;69(2):244-57 20691755 - Neurosci Lett. 2010 Oct 11;483(2):127-31 18573915 - J Cell Biol. 2008 Jun 30;181(7):1169-77 22217583 - Mult Scler. 2012 Feb;18(2):133-7 11944939 - Dev Biol. 2002 Apr 15;244(2):305-18 2414073 - Cytogenet Cell Genet. 1985;39(4):241-5 25362473 - Nat Neurosci. 2014 Dec;17(12):1664-72 11394997 - Neuron. 2001 May;30(2):335-44 24747166 - J Vis Exp. 2014 Apr 13;(86):null 19185024 - J Neurosci Res. 2009 Jun;87(8):1773-93 19343313 - Results Probl Cell Differ. 2009;48:1-28 22462667 - J Peripher Nerv Syst. 2012 Mar;17(1):62-71 11395000 - Neuron. 2001 May;30(2):369-83 24719087 - J Neurosci. 2014 Apr 9;34(15):5083-8 11880502 - J Neurosci. 2002 Mar 1;22(5):1726-37 16766541 - Brain. 2006 Dec;129(Pt 12):3186-95 23664614 - Neuron. 2013 May 8;78(3):469-82 17846150 - J Exp Med. 2007 Oct 1;204(10):2363-72 24011083 - BMC Neurosci. 2013 Sep 06;14:96 24971750 - PLoS One. 2014 Jun 27;9(6):e100834 23100406 - Neurology. 2012 Dec 4;79(23):2241-8 16337912 - Neuron. 2005 Dec 8;48(5):737-42 22243749 - Neuron. 2012 Jan 12;73(1):92-107 9412484 - J Neurosci. 1998 Jan 1;18(1):36-47 9464989 - J Neurosci. 1998 Mar 1;18(5):1642-9 15148385 - Proc Natl Acad Sci U S A. 2004 May 25;101(21):8168-73 23404451 - J Neurosci Res. 2013 May;91(5):603-22 11343647 - Neuron. 2001 Apr;30(1):91-104 24626186 - Cell Cycle. 2014;13(9):1400-12 9125370 - J Neurosci Methods. 1997 Jan;71(1):3-9 12481300 - Genesis. 2003 Jan;35(1):63-72 8569154 - Lab Anim Sci. 1995 Oct;45(5):547-53 Oh (B24) 2010; 483 Bhat (B3) 2001; 30 Young (B35) 2008; 11 Zonta (B37) 2011; 69 Coman (B7) 2006; 129 Schulz (B28) 2014 Heimer-McGinn (B18) 2011; 49 McCloy (B22) 2014; 13 Pillai (B26) 2009; 87 Thaxton (B34) 2011; 69 Thaxton (B33) 2009; 48 Basak (B2) 2007; 311 Garcia-Fresco (B15) 2006; 103 Shi (B30) 2014; 9 Buttermore (B5) 2013; 91 Zhang (B36) 2012; 73 Zonta (B38) 2008; 181 Arroyo (B1) 2002; 22 Desmazieres (B11) 2014; 34 Desmazieres (B10) 2012; 18 Ng (B23) 2012; 79 Pedraza (B25) 2001; 30 Green (B16) 2013; 14 Ho (B19) 2014; 17 Boiko (B4) 2001; 30 Delaney (B9) 1995; 45 Devaux (B12) 2012; 17 Craner (B8) 2004; 101 Caroni (B6) 1997; 71 Dupree (B14) 1998; 18 Sidman (B31) 1985; 39 Sherman (B29) 2005; 48 Doerflinger (B13) 2003; 35 Mathey (B21) 2007; 204 Hayashi (B17) 2002; 244 Susuki (B32) 2013; 78 Lambert (B20) 1997; 17 Rasband (B27) 1998; 18 |
References_xml | – volume: 18 start-page: 1642 year: 1998 ident: B14 article-title: Myelin galactolipids are essential for proper node of Ranvier formation in the CNS publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-05-01642.1998 contributor: fullname: Dupree – volume: 87 start-page: 1773 year: 2009 ident: B26 article-title: Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains publication-title: J. Neurosci. Res. doi: 10.1002/jnr.22015 contributor: fullname: Pillai – volume: 204 start-page: 2363 year: 2007 ident: B21 article-title: Neurofascin as a novel target for autoantibody-mediated axonal injury publication-title: J. Exp. Med. doi: 10.1084/jem.20071053 contributor: fullname: Mathey – volume: 34 start-page: 5083 year: 2014 ident: B11 article-title: Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4662-13.2014 contributor: fullname: Desmazieres – volume: 48 start-page: 737 year: 2005 ident: B29 article-title: Neurofascins are required to establish axonal domains for saltatory conduction publication-title: Neuron doi: 10.1016/j.neuron.2005.10.019 contributor: fullname: Sherman – volume: 9 start-page: e100834 year: 2014 ident: B30 article-title: The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in Mice publication-title: PLoS ONE doi: 10.1371/journal.pone.0100834 contributor: fullname: Shi – volume: 45 start-page: 547 year: 1995 ident: B9 article-title: Familial dysmyelination in a Long Evans rat mutant publication-title: Lab. Anim. Sci. contributor: fullname: Delaney – volume: 39 start-page: 241 year: 1985 ident: B31 article-title: Shiverer gene maps near the distal end of chromosome 18 in the house mouse publication-title: Cytogenet. Cell Genet. doi: 10.1159/000132151 contributor: fullname: Sidman – volume: 11 start-page: 721 year: 2008 ident: B35 article-title: Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice publication-title: Nat. Neurosci. doi: 10.1038/nn.2118 contributor: fullname: Young – volume: 35 start-page: 63 year: 2003 ident: B13 article-title: Inducible site-specific recombination in myelinating cells publication-title: Genesis doi: 10.1002/gene.10154 contributor: fullname: Doerflinger – volume: 17 start-page: 7025 year: 1997 ident: B20 article-title: Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-18-07025.1997 contributor: fullname: Lambert – volume: 483 start-page: 127 year: 2010 ident: B24 article-title: The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2010.07.076 contributor: fullname: Oh – volume: 18 start-page: 133 year: 2012 ident: B10 article-title: Changes at the nodal and perinodal axonal domains: a basis for multiple sclerosis pathology? publication-title: Mult. Scler. doi: 10.1177/1352458511434370 contributor: fullname: Desmazieres – volume: 129 start-page: 3186 issue: Pt 12 year: 2006 ident: B7 article-title: Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis publication-title: Brain doi: 10.1093/brain/awl144 contributor: fullname: Coman – volume: 78 start-page: 469 year: 2013 ident: B32 article-title: Three mechanisms assemble central nervous system nodes of Ranvier publication-title: Neuron doi: 10.1016/j.neuron.2013.03.005 contributor: fullname: Susuki – volume: 30 start-page: 369 year: 2001 ident: B3 article-title: Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin publication-title: Neuron doi: 10.1016/S0896-6273(01)00294-X contributor: fullname: Bhat – volume: 48 start-page: 1 year: 2009 ident: B33 article-title: Myelination and regional domain differentiation of the axon publication-title: Results Probl. Cell Differ. doi: 10.1007/400_2009_3 contributor: fullname: Thaxton – volume: 13 start-page: 1400 year: 2014 ident: B22 article-title: Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events publication-title: Cell Cycle doi: 10.4161/cc.28401 contributor: fullname: McCloy – volume: 18 start-page: 36 year: 1998 ident: B27 article-title: Potassium channel distribution, clustering, and function in remyelinating rat axons publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-01-00036.1998 contributor: fullname: Rasband – volume: 22 start-page: 1726 year: 2002 ident: B1 article-title: Genetic dysmyelination alters the molecular architecture of the nodal region publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-05-01726.2002 contributor: fullname: Arroyo – volume: 17 start-page: 62 year: 2012 ident: B12 article-title: Nodal proteins are target antigens in Guillain-Barre syndrome publication-title: J. Peripher. Nerv. Syst. doi: 10.1111/j.1529-8027.2012.00372.x contributor: fullname: Devaux – start-page: 86 year: 2014 ident: B28 article-title: In vivo electrophysiological measurements on mouse sciatic nerves publication-title: J. Vis. Exp. doi: 10.3791/51181 contributor: fullname: Schulz – volume: 181 start-page: 1169 year: 2008 ident: B38 article-title: Glial and neuronal isoforms of Neurofascin have distinct roles in the assembly of nodes of Ranvier in the central nervous system publication-title: J. Cell Biol. doi: 10.1083/jcb.200712154 contributor: fullname: Zonta – volume: 30 start-page: 335 year: 2001 ident: B25 article-title: Organizing principles of the axoglial apparatus publication-title: Neuron doi: 10.1016/S0896-6273(01)00306-3 contributor: fullname: Pedraza – volume: 30 start-page: 91 year: 2001 ident: B4 article-title: Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon publication-title: Neuron doi: 10.1016/S0896-6273(01)00265-3 contributor: fullname: Boiko – volume: 17 start-page: 1664 year: 2014 ident: B19 article-title: A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier publication-title: Nat. Neurosci. doi: 10.1038/nn.3859 contributor: fullname: Ho – volume: 103 start-page: 5137 year: 2006 ident: B15 article-title: Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0601082103 contributor: fullname: Garcia-Fresco – volume: 79 start-page: 2241 year: 2012 ident: B23 article-title: Neurofascin as a target for autoantibodies in peripheral neuropathies publication-title: Neurology doi: 10.1212/WNL.0b013e31827689ad contributor: fullname: Ng – volume: 71 start-page: 3 year: 1997 ident: B6 article-title: Overexpression of growth-associated proteins in the neurons of adult transgenic mice publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(96)00121-5 contributor: fullname: Caroni – volume: 101 start-page: 8168 year: 2004 ident: B8 article-title: Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0402765101 contributor: fullname: Craner – volume: 73 start-page: 92 year: 2012 ident: B36 article-title: Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms publication-title: Neuron doi: 10.1016/j.neuron.2011.10.016 contributor: fullname: Zhang – volume: 311 start-page: 408 year: 2007 ident: B2 article-title: Differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during PNS development publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2007.08.045 contributor: fullname: Basak – volume: 69 start-page: 945 year: 2011 ident: B37 article-title: A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment publication-title: Neuron doi: 10.1016/j.neuron.2011.02.021 contributor: fullname: Zonta – volume: 244 start-page: 305 year: 2002 ident: B17 article-title: Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0597 contributor: fullname: Hayashi – volume: 49 start-page: 942 year: 2011 ident: B18 article-title: Efficient inducible Pan-neuronal cre-mediated recombination in SLICK-H transgenic mice publication-title: Genesis doi: 10.1002/dvg.20777 contributor: fullname: Heimer-McGinn – volume: 69 start-page: 244 year: 2011 ident: B34 article-title: Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons publication-title: Neuron doi: 10.1016/j.neuron.2010.12.016 contributor: fullname: Thaxton – volume: 91 start-page: 603 year: 2013 ident: B5 article-title: Organization and maintenance of molecular domains in myelinated axons publication-title: J. Neurosci. Res. doi: 10.1002/jnr.23197 contributor: fullname: Buttermore – volume: 14 start-page: 96 year: 2013 ident: B16 article-title: Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons publication-title: BMC Neurosci. doi: 10.1186/1471-2202-14-96 contributor: fullname: Green |
SSID | ssj0062648 |
Score | 2.2996173 |
Snippet | Intricate molecular interactions between neurons and glial cells underlie the creation of unique domains that are essential for saltatory conduction of action... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 11 |
SubjectTerms | Amino acids Axons Cell adhesion & migration Cell surface Conduction Glial cells Immunoglobulins Microscopy Nervous system Neurodegeneration Neuronal-glial interactions Neuroscience Nodes of Ranvier Potassium Proteins Sodium channels (voltage-gated) |
SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKyEuiDeBgozEhUPU-BHbOVXb0qVC7ApVVOotcmJbRVo5hd1K9Mg_74zjXViQuCZxXp_tmc_feIaQdzoEaxpVl1WoZCl7wUpTB1OGgBs5vXNS4X7n-UKdnstPF_VFXnBb5bDKzZyYJmo39LhGfsC5YYIJ3bDDq-8lVo1CdTWX0LhL9jgTxkzI3tHJ4svZZi5WGL81ipNAxZqDAD8S9QaW8hYytmuM_vEw_w6U_MPyzB6SB9llpNMR40fkjo-Pyb15FsWfkF9YcDfiMgz9DE-hQ6Ap5QY2stHRj0voY-OhYMHixRX9kMuiwPBeLm_odAzqoIvBeWx-ZiOaSzq3mE0CU3L4dKf5De5eB-_U0enPIdIZGEUE9ik5n518PT4tc2WFspdNtS5lbWzfaxF6oGOVaLzxjQ7K99wE1mnnXai0r7gFtsG9NCi_ea6VY7IHymjFMzKJQ_QvCAU6xGVQjUYFM_CuU0Eq0anO9dJp5wryfvOL26sxgUYLxAPhaBMcLcKRNHBWkP0NBm0eSqv2N_AFebs9DYMAlQ0b_XC9ahmqtVJB7yrI8xGy7cOAUzINjmZB9A6Y2wswwfbumfjtMiXarhMb5S___1qvyH38hBTKLfbJZP3j2r8GT2Xdvcnd8RZKrOy- priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT9swFLYQSNMu02Bj61aQkXbZISyxHds5IFTBCkILh4lK3CIntjWkytlokdoj__nec9KObpx2jfMSxd-z3nv53g9CPinvjS5knqQ-FYloeJbo3OvEeyzkdNYKifXO5bW8nIir2_z2T3l0v4GzZ0M7nCc1uZ8eL34tT-HAn2DECfb2i4ftQRYhi90IsdB3h4FdxASvUqw5BYm5XB1R-awUtgXW4KCnmm_aqH8cz7_zJ58YpPFr8qr3JOmog36XbLmwR16UPVf-hjziHN6Af2foN3gLbT2NnThQyARLL6aget0lb8AQhhk976elwKmfTpd01OV60OvWOhT_bgJaUVoabDKBnTpcfFK5xKJ2cFotHS3aQMdgKxHvt2Qy_npzdpn0AxeSRhTpPBG5Nk2juG8gSkt54bQrlJeuYdpntbLO-lS5lBkIQpgTGlk5x5S0mWggkjR8n2yHNrj3hEKUxISXhUJi07O6ll5IXsvaNsIqawfk82qLq59dX40K4hFEporIVIhMpMazARmuMKhWClIxpjOecVXA8tF6Gc4GEh4muPZhVmVI4goJSjcg7zrI1i9bYT0gagPM9Q3Yd3tzJdz9iP238xiksg__LfmRvMSvi8nffEi25_cP7gB8m3l9GFX2Nzed_Eg priority: 102 providerName: Scholars Portal |
Title | Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function |
URI | https://www.ncbi.nlm.nih.gov/pubmed/28217083 https://www.proquest.com/docview/2281313791 https://search.proquest.com/docview/1870646829 https://pubmed.ncbi.nlm.nih.gov/PMC5289982 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJCqWX0Hc3TRcVeunBWcuSJfm4eWxCqZcQGtibsfWggY0cshtIjv3nnZHtpdveetHBsixbM_LMp3kR8kV5X-tC5knqU5EIw1mic68T7zGQ01krJMY7l3N5cS2-LfLFDsmHWJjotG-am6OwvD0KNz-jb-XdrZkMfmKTy_Ikjyghm-ySXRC_A0Tvfr8SXbY6eySgr2LiYe3QxMBiqkKGlWEAZTCVar4tiv7RL_92k_xD7sxekv1eYaTT7sVekR0XXpPnZW8Sf0N-YbndgIcw9DvMQltPY8INHFQHS8-XwGHdJV-DvAsretoXRYHNvVw-0Wnn0kHnrXU4_KoOKCxpWWMuCUzI4eKTyieMXQfd1NLpYxvoDEQikvUtuZ6d_Ti5SPq6CokRRbpORK5rYxT3BsBYygunXaG8dCbTnjXKOutT5dKsBqyROaHR-OYyJS0TBgBjzd-RvdAG94FQAEOZ8LJQaL_0WdNILyRvZGONsMraEfk6LHF116XPqAB2IGWqSJkKKRMt4GxEDgcaVP1GWlVZphlnXBXQ_XnTDVsA7Rp1cO3DqmJoqxUSeGtE3nck20w20HpE1BYxNzdgeu3tHuC6mGa757KD_x75kbzAr4s-3vyQ7K3vH9wnUGHWzZg8Oz6bX16N4xEAtOcLBm0p9Dgy829m8fjH |
link.rule.ids | 230,314,727,780,784,864,885,21388,24318,27924,27925,33744,33745,43805,53791,53793,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVgIuqLxKSgtG4sIhauw4dnJCS9tlgc0KVa3UW5T4IZBWTmG3Unvkn-NxvAsLEtckzuuzPfP5G88AvJHWtmUlijSzGU-5ymlaFrZMrcWNnEZrLnC_cz0X0wv-6bK4jAtuyxhWuZ4Tw0Ste4Vr5EeMlTSnuazou6vvKVaNQnU1ltC4CzuYOb0Ywc770_mXs_VcLDB-axAnPRWrjqz_kag30JC3kNJtY_SPh_l3oOQflmeyCw-jy0jGA8aP4I5xj-FeHUXxJ_ATC-46XIYhM_8U0lsSUm5go9Zp8mHh-9hwyLbe4rklOYllUfzwXixuyXgI6iDzXhtsftY6NJekbjGbBKbkMOFO9S3uXvfeqSbjm96RiTeKCOxTuJicnh9P01hZIVW8ylYpL8pWKZlb5elYllemNJW0wihWWtpJbbTNpMlY69kGM7xE-c0wKTTlylPGNn8GI9c78xyIp0OMW1FJVDAt6zphucg70WnFtdQ6gbfrX9xcDQk0Gk88EI4mwNEgHEEDpwkcrDFo4lBaNr-BT-D15rQfBKhstM7018uGolrLhe9dCewNkG0e5jklld7RTEBugbm5ABNsb59x376GRNtFYKNs__-v9QruT8_rWTP7OP_8Ah7g54Sw7vwARqsf1-bQey2r7mXsmr8Aflfvpg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVqq4VJRnoICRuHCINnYcOzmhhXYp0F1VFZV6i5zYFpVWTmG3Ej3yz5lJvFsWJK5xnIdn7JnP33gG4I323pSVKtLMZzKVbc7TsvBl6j0d5HTWSkXnnWdzdXwuP18UFzH-aRnDKtdrYr9Q266lPfKxECXPea4rPvYxLOL0cPru6ntKFaSIaY3lNO7CDlrFTIxg5_3R_PRsvS4riuUaiEqEZdXY46AS98D7HIacbxumf7zNv4Mm_7BC0_uwF91HNhnkvQ93XHgAu7NIkD-EX1R8N9CWDDvBt7DOsz79BnUywbKPC9S34ZI3aP3Ckh3GEik41ReLGzYZAjzYvLOOup-ZQKaTzQxllqD0HK5_0uyGTrKjp2rZ5GcX2BQNJAn5EZxPj75-OE5jlYW0lVW2SmVRmrbVuW8RmmV55UpXaa9cK0rPG22d9Zl2mTCIPISTJVFxTmhluWwRPpr8MYxCF9xTYAiNhPSq0sRmetE0ykuVN6qxrbTa2gTeroe4vhqSadQIQkgcdS-OmsTR8-E8gYO1DOo4rZb1rRIk8HrTjBOCWA4TXHe9rDkxt1KhpiXwZBDZ5mWIL7lGpzMBvSXMzQ2UbHu7JVx-65NuFz0yFc_-_1mvYBe1sj75NP_yHO7R3_QR3vkBjFY_rt0LdGBWzcuomb8BXx_z0w |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Postnatal+Loss+of+Neuronal+and+Glial+Neurofascins+Differentially+Affects+Node+of+Ranvier+Maintenance+and+Myelinated+Axon+Function&rft.jtitle=Frontiers+in+cellular+neuroscience&rft.au=Taylor%2C+Anna+M.&rft.au=Saifetiarova%2C+Julia&rft.au=Bhat%2C+Manzoor+A.&rft.date=2017-02-03&rft.pub=Frontiers+Media+S.A&rft.eissn=1662-5102&rft.volume=11&rft_id=info:doi/10.3389%2Ffncel.2017.00011&rft_id=info%3Apmid%2F28217083&rft.externalDBID=PMC5289982 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-5102&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-5102&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-5102&client=summon |