The enhancement of endothelial cell therapy for angiogenesis in hindlimb ischemia using hyaluronan

• Published in: Biomaterials Vol. 32; no. 1; pp. 75 - 86
• Main Authors: Tang, Zack C.W, Liao, Wei-Yin, Tang, Alan C.L, Tsai, Shih-Jung, Hsieh, Patrick C.H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2011
• Subjects: Advanced Basic Science; Angiogenesis; animal injuries; animal models; Animals; apoptosis; Apoptosis - drug effects; arteries; Arteries - drug effects; Arteries - growth & development; blood; cell culture; cell growth; Cell Proliferation - drug effects; cell transplantation; Cell- and Tissue-Based Therapy - methods; Cells, Cultured; Dentistry; Endothelial cell; endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - transplantation; Hindlimb - blood supply; hindlimbs; Humans; Hyaluronan; hyaluronic acid; Hyaluronic Acid - pharmacology; immunocompromised population; injection; Injections; ischemia; Ischemia - pathology; Ischemia - therapy; Mice; Mice, Nude; Neovascularization, Physiologic - drug effects; Organogenesis - drug effects; Peripheral artery occlusive disease; Treatment Outcome; umbilical veins; Umbilical Veins - cytology; vascular diseases; Angiogenesis; Hyaluronan; Endothelial cell; Peripheral artery occlusive disease

Abstract Growing evidence shows that injection of hyaluronan (HA) benefits ischemic injury in animals. On the other hand, cell therapy is an emerging approach to treat occlusive arterial diseases, although the low retention rate of cells after direct injection remains a major concern. Here, we teste...