Brief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice

• Published in: Journal of autism and developmental disorders Vol. 43; no. 6; pp. 1452 - 1458
• Main Authors: Heitzer, Andrew M., Roth, Alexandra K., Nawrocki, Lauren, Wrenn, Craige C., Valdovinos, Maria G.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2013; Springer; Springer Nature B.V
• Subjects: Animal Behavior; Animals; Autism; Behavior; Behavior, Animal - physiology; Behavioral Science and Psychology; Biological and medical sciences; Brief Report; Child and School Psychology; Child clinical studies; Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...); Cognitive Development; Disease Models, Animal; Fragile X Mental Retardation Protein - genetics; Fragile X Syndrome - genetics; Genetic Disorders; Intellectual disabilities; Laboratory animals; Medical genetics; Medical sciences; Mental Retardation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurosciences; Novelty (Stimulus Dimension); Pediatrics; Proteins; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Public Health; Reproducibility of Results; Social anxiety; Social Behavior; Social behavior disorders; Social Cognition; Social interaction; Social Isolation; Withdrawal (Psychology); United States > US; Illinois; Des Moines Iowa; knockout mouse; Social behavior; Fragile X syndrome; Chromosome fragility; Animal model; fmr1 knockout mouse; Rodentia; Experimental study; Vertebrata; Mammalia; Mouse; Social interaction; Social isolation; Animal; Knockout mouse; Social behavior disorder

Social behavior abnormalities in Fragile X syndrome (FXS) are characterized by social withdrawal, anxiety, and deficits in social cognition. To assess these deficits, a model of FXS, the Fmr1 knockout mouse ( Fmr1 KO), has been utilized. This mouse model has a null mutation in the fragile X mental r...