Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model - Higuchi, Kei; Kitamura, Atsushi; Okura, Takashi; Deguchi, Yoshiharu (Drug metabolism and pharmacokinetics, 2015)
Keywords: Active transport; Biological Transport; Blood-Brain Barrier - cytology; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Blood–brain barrier; Cell Line, Transformed; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Feasibility Studies; hCMEC/D3 cells; Humans; Kinetics; Memantine; Memantine - metabolism; Membrane Transport Modulators - pharmacology; Models, Biological; Organic Cation Transport Proteins - antagonists & inhibitors; Organic Cation Transport Proteins - metabolism; Proton-coupled organic cation antiporter; RNA Interference; Transfection; Proton-coupled organic cation antiporter; Active transport; Memantine; hCMEC/D3 cells; Blood–brain barrier