Mast Cell Neural Interactions in Health and Disease

• Published in: Frontiers in cellular neuroscience Vol. 13; p. 110
• Main Authors: Mittal, Aditya, Sagi, Varun, Gupta, Mihir, Gupta, Kalpna
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 20.03.2019; Frontiers Media S.A
• Subjects: blood brain barrier; Cell activation; Cell adhesion & migration; Central nervous system; Chemokines; Cytokines; Degranulation; endothelial cell; Histamine; Inflammation; Kinases; mast cell; Mast cells; Meninges; Nanotubes; Nervous system; Neuropeptides; Neuroscience; Pain; Proteins; Spinal cord; Traps; Tumor necrosis factor-TNF; United States > US; blood brain barrier; mast cell; pain; nervous system; inflammation; endothelial cell

Mast cells (MCs) are located in the periphery as well as the central nervous system (CNS). Known for sterile inflammation, MCs play a critical role in neuroinflammation, which is facilitated by their close proximity to nerve fibers in the periphery and meninges of the spinal cord and the brain. Mult...