Lymphocytic Extracellular Signal–Regulated Kinase Dysregulation in Autism Spectrum Disorder

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 62; no. 5; pp. 582 - 592.e2
• Main Authors: Erickson, Craig A., Tessier, Charles R., Gross, Christina, Pedapati, Ernest V., Wink, Logan K., Dominick, Kelli C., Shaffer, Rebecca C., Rosselot, Hilary, Hong, Michael P., Bantel, Andrew P., Berry-Kravis, Elizabeth, Horn, Paul S., Adams, Ryan, Sweeney, John A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023; Elsevier BV
• Subjects: Age; Aged; Anatomy; Animals; Autism; Autism Spectrum Disorder; Autism Spectrum Disorders; Autistic Disorder; Behavior; biomarker; Brain; Cell activation; Child; Coding; Control Groups; Data collection; Developmental disabilities; Developmental plasticity; Disability; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases; Female; Flow cytometry; Fragile X Syndrome; Gender; Humans; Idiopathic; Intellectual disabilities; Intelligence; Intelligence Quotient; Intelligence tests; Intracellular signalling; Kinases; Kinetics; lymphocyte; Lymphocytes; Male; Molecular biology; Older people; Pediatrics; Phosphorylation; Plasticity; Psychiatric/Mental Health; Recruitment; Stimulation; Verbal Communication; extracellular signal-regulated kinase; autism spectrum disorder; biomarker; autism; lymphocyte

Extracellular signal-regulated kinase (ERK1/2) is a conserved central intracellular signaling cascade involved in many aspects of neuronal development and plasticity. Converging evidence support investigation of ERK1/2 activity in autism spectrum disorder (ASD). We previously reported enhanced basel...