Long-term exercise stimulates adenosine monophosphate–activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver

• Published in: Metabolism, clinical and experimental Vol. 55; no. 8; pp. 1122 - 1128
• Main Authors: Takekoshi, Kazuhiro, Fukuhara, Michiko, Quin, Zeng, Nissato, Sumiko, Isobe, Kazumasa, Kawakami, Yasushi, Ohmori, Hajime
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2006; Elsevier
• Subjects: Adipose Tissue - enzymology; AMP-Activated Protein Kinases; Animals; Biological and medical sciences; Blood Glucose - metabolism; Blotting, Western; Body Weight - physiology; Cholesterol - blood; Cholesterol, HDL - blood; Liver - enzymology; Male; Medical sciences; Metabolic diseases; Multienzyme Complexes - biosynthesis; Multienzyme Complexes - metabolism; Oxygen Consumption - physiology; Physical Conditioning, Animal - physiology; Protein-Serine-Threonine Kinases - biosynthesis; Protein-Serine-Threonine Kinases - metabolism; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Triglycerides - blood; Physical exercise; Adipose tissue; Rat; Digestive system; Enzyme; Transferases; Liver; Rodentia; Activity; Gene expression; Subunit; Long term; Vertebrata; Mammalia; Adenosine kinase; Protein kinase; Animal

Adenosine monophosphate–activated protein kinase (AMPK) is activated in response to adenosine triphosphate depletion caused by the metabolic and nutritional state. Mammalian AMPK is a heterotrimeric enzyme composed of a catalytic α subunit and 2 regulatory subunits ( β and γ). Although much attentio...