Stem Cell-Derived Models of Neural Crest Are Essential to Understand Melanoma Progression and Therapy Resistance

• Published in: Frontiers in molecular neuroscience Vol. 12; p. 111
• Main Authors: Larribère, Lionel, Utikal, Jochen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 01.05.2019; Frontiers Media S.A
• Subjects: Cancer therapies; Cell culture; Cell differentiation; Epidermis; Gene regulation; Genotype & phenotype; iPSCs; Melanocytes; Melanoma; Mesenchyme; Metastases; Mutation; Neural crest; Neural stem cells; Neural tube; Neuroscience; Phenotypes; Population; Regulation; resistance; Stem cells; Transcription factors; Tumor cells; Tumors; Germany; iPSCs; stem cells; melanoma; neural crest; resistance

During development, neural crest (NC) cells are early precursors of several lineages including melanocytes. Along their differentiation from multipotent cells to mature melanocytes, NC cells will go through successive steps which require either proliferative or motile capacities. For example, they w...