Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control

• Published in: Chinese medicine Vol. 20; no. 1; pp. 27 - 15
• Main Authors: You, Baiyang, Zhang, Jie, Yang, Chuyan, Dun, Yaoshan, Qi, Dake, Long, Yuqiong, Cheng, Jing, Lin, Yuan, Zhou, Nanjiang, Zeng, Tanghao, Dong, Jie, Liu, Suixin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2025; BioMed Central; BMC
• Subjects: Animal models; Apoptosis; Cardiomyocyte apoptosis; Cardiomyocytes; Care and treatment; Coronary artery; Coronary vessels; Crystal structure; Cytokines; Development and progression; Echocardiography; Health aspects; Heart attack; Heart attacks; Heart failure; Hypoxia; Intubation; Ischemia; Kinases; Laboratory animals; Leukocyte migration; Ligands; Macrophage migration inhibitory factor; Medical prognosis; Mitochondria; Mitochondrial quality control; Mortality; Myocardial infarction; Myocardium; Ostomy; Physiological aspects; Proteins; Quality control; Salidroside; siRNA; Surgery; Transfection; Transmission electron microscopy; Veins & arteries; Ventilation; China; United States > US; Macrophage migration inhibitory factor; Myocardial infarction; Salidroside; Cardiomyocyte apoptosis; Mitochondrial quality control

Salidroside is a potential therapeutic agent for myocardial infarction (MI), exerting therapeutic effects on macrophage migration inhibitory factor (MIF)-regulated mitochondrial quality control. Our aim was to explore the mechanism through which the MIF pathway regulates salidroside-mediated resista...