Hypoadiponectinemia is Related to Sympathetic Activation and Severity of Obstructive Sleep Apnea

• Published in: Sleep (New York, N.Y.) Vol. 31; no. 12; pp. 1721 - 1727
• Main Authors: LAM, Jamie C. M, AIMIN XU, TAM, Sidney, KHONG, Pek-Lan, YAO, Tzy-Jyun, LAM, David C. L, LAI, Agnes Y. K, LAM, Bing, LAM, Karen S. L, IP, Mary S. M
• Format: Journal Article
• Language: English
• Published: Darien, IL American Academy of Sleep Medicine 01.12.2008; Associated Professional Sleep Societies, LLC
• Subjects: Adiponectin - blood; Adult; Behavioral psychophysiology; Biological and medical sciences; Body Composition - physiology; Body Mass Index; Cohort Studies; Cross-Sectional Studies; Down-Regulation - physiology; Enzyme-Linked Immunosorbent Assay; Fundamental and applied biological sciences. Psychology; Humans; Hypoadiponectinemia and OSA; Intra-Abdominal Fat - physiopathology; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Pneumology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Respiratory system : syndromes and miscellaneous diseases; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - physiopathology; Subcutaneous Fat, Abdominal - physiopathology; Sympathetic Nervous System - physiopathology; Nervous system diseases; Sleep apnea syndrome; Activation; Sympathetic nervous system; Respiratory disease; Autonomic nervous system

Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep d...