Polygenic dissection of the bipolar phenotype

• Published in: British journal of psychiatry Vol. 198; no. 4; pp. 284 - 288
• Main Authors: Hamshere, M L, O'Donovan, M C, Jones, I R, Jones, L, Kirov, G, Green, E K, Moskvina, V, Grozeva, D, Bass, N, McQuillin, A, Gurling, H, St Clair, D, Young, A H, Ferrier, I N, Farmer, A, McGuffin, P, Sklar, P, Purcell, S, Holmans, P A, Owen, M J, Craddock, N
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 01.04.2011; Royal College Of Psychiatrists
• Subjects: Adolescent; Alleles; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - genetics; Case-Control Studies; Consortia; Diagnostic and Statistical Manual of Mental Disorders; Dissection; Genetic Linkage; Genetic Predisposition to Disease; Genetic susceptibility; Genomes; Genotype; Genotype & phenotype; Humans; International Classification of Diseases; Logistic Models; Mental disorders; Multifactorial Inheritance; Phenotype; Phenotypes; Polymorphism, Single Nucleotide; Principal components analysis; Psychiatry; Psychoses; Psychosis; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Psychotic symptoms; Replication; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Susceptibility; United Kingdom; United Kingdom > UK

Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder. To test hypotheses about the relationship between schizophrenia and psychotic t...