D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans

• Published in: NeuroImage (Orlando, Fla.) Vol. 54; no. 4; pp. 2915 - 2921
• Main Authors: Fazio, Leonardo, Blasi, Giuseppe, Taurisano, Paolo, Papazacharias, Apostolos, Romano, Raffaella, Gelao, Barbara, Ursini, Gianluca, Quarto, Tiziana, Lo Bianco, Luciana, Di Giorgio, Annabella, Mancini, Marina, Popolizio, Teresa, Rubini, Giuseppe, Bertolino, Alessandro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.02.2011; Elsevier Limited
• Subjects: [123I] FP-CIT SPECT; Age; Alternative splicing; Behavior; Brain; Brain Mapping; Corpus Striatum - physiology; Dopamine; Dopamine - metabolism; Dopamine D2 Receptor Polymorphism; Female; fMRI; Genotype; Genotype & phenotype; Humans; Imaging genetics; Magnetic Resonance Imaging; Male; Motor Activity - genetics; Motor brain activity; Motor Cortex - physiology; Multimodal; Polymorphism, Single Nucleotide; Reaction Time; Receptors, Dopamine D2 - genetics; Signal transduction; Signal Transduction - genetics; Studies; Tomography, Emission-Computed, Single-Photon; Young Adult; Imaging genetics; fMRI; Dopamine D2 Receptor Polymorphism; Motor brain activity; Multimodal; [123I] FP-CIT SPECT

Pre-synaptic D2 receptors regulate striatal dopamine release and DAT activity, key factors for modulation of motor pathways. A functional SNP of DRD2 (rs1076560 G>T) is associated with alternative splicing such that the relative expression of D2S (mainly pre-synaptic) vs. D2L (mainly post-synapti...