The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4

• Published in: British journal of nutrition Vol. 105; no. 1; pp. 15 - 23
• Main Author: Erridge, Clett
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.01.2011
• Subjects: adverse effects; Bacteria; Biological and medical sciences; Cell Line; Cellular biology; cooking; Cytokines; cytology; Diet; Diet - adverse effects; etiology; Feeding. Feeding behavior; Food; Food - adverse effects; Food Handling; Fundamental and applied biological sciences. Psychology; Humans; Immune system; inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation Mediators; Inflammation Mediators - metabolism; Ingestion; interleukin-6; Interleukin-6 - secretion; Kidney; Kidney - cytology; Lipopeptides; Lipopeptides - metabolism; lipopolysaccharides; Lipopolysaccharides - metabolism; meat products; metabolism; monocytes; Monocytes - metabolism; Nutrition research; Nutritional Immunology; Processed foods; proteinases; Proteins; raw fruit; receptors; Reference Values; secretion; Signal Transduction; Solubility; temperature; Toll-Like Receptor 2; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4; Toll-Like Receptor 4 - metabolism; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - secretion; vegetables; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Toll-like receptors; Inflammation; Endotoxins; Food; Human; Monocyte; Toll like receptor; Activation; Foodstuff; Endotoxin; In vitro; Toxin; Vertebrata; Mammalia

The ingestion of fatty meals is associated with a transient, low-grade systemic inflammatory response in human subjects, involving the activation of circulating monocytes and the secretion of pro-inflammatory cytokines. However, it is not yet clear how different foodstuffs may promote inflammatory s...