Personalized tDCS for Focal Epilepsy—A Narrative Review: A Data-Driven Workflow Based on Imaging and EEG Data

Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advan...

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Published inBrain sciences Vol. 12; no. 5; p. 610
Main Authors Beumer, Steven, Boon, Paul, Klooster, Debby C. W., van Ee, Raymond, Carrette, Evelien, Paulides, Maarten M., Mestrom, Rob M. C.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.05.2022
MDPI
Subjects
Brain research
clinical outcome
Convulsions & seizures
Customization
EEG
Electric fields
Electrodes
Electroencephalography
Epilepsy
forward modeling
Hypotheses
inverse modeling
Localization
Magnetic resonance imaging
Neuroimaging
Neurons
neurostimulation
Parkinson's disease
personalized
Quality of life
Review
Reviews
Segmentation
transcranial electric stimulation
Transcranial magnetic stimulation
forward modeling
inverse modeling
transcranial electric stimulation
clinical outcome
personalized
neurostimulation
Online AccessGet full text
ISSN2076-3425
2076-3425
DOI10.3390/brainsci12050610

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Abstract Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results. Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments. Through this narrative review, we present a processing workflow to personalize tES for focal epilepsy, for which there is a clear cortical target to stimulate. The workflow utilizes clinical imaging and electroencephalography data and enables us to relate the simulated fields to clinical outcomes. We review and analyze the relevant literature for the processing steps in the workflow, which are the following: tissue segmentation, source localization, and stimulation optimization. In addition, we identify shortcomings and ongoing trends with regard to, for example, segmentation quality and tissue conductivity measurements. The presented processing steps result in personalized tES based on metrics like focality and field strength, which allow for correlation with clinical outcomes.
AbstractList Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results. Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments. Through this narrative review, we present a processing workflow to personalize tES for focal epilepsy, for which there is a clear cortical target to stimulate. The workflow utilizes clinical imaging and electroencephalography data and enables us to relate the simulated fields to clinical outcomes. We review and analyze the relevant literature for the processing steps in the workflow, which are the following: tissue segmentation, source localization, and stimulation optimization. In addition, we identify shortcomings and ongoing trends with regard to, for example, segmentation quality and tissue conductivity measurements. The presented processing steps result in personalized tES based on metrics like focality and field strength, which allow for correlation with clinical outcomes.
Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results. Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments. Through this narrative review, we present a processing workflow to personalize tES for focal epilepsy, for which there is a clear cortical target to stimulate. The workflow utilizes clinical imaging and electroencephalography data and enables us to relate the simulated fields to clinical outcomes. We review and analyze the relevant literature for the processing steps in the workflow, which are the following: tissue segmentation, source localization, and stimulation optimization. In addition, we identify shortcomings and ongoing trends with regard to, for example, segmentation quality and tissue conductivity measurements. The presented processing steps result in personalized tES based on metrics like focality and field strength, which allow for correlation with clinical outcomes.Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results. Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments. Through this narrative review, we present a processing workflow to personalize tES for focal epilepsy, for which there is a clear cortical target to stimulate. The workflow utilizes clinical imaging and electroencephalography data and enables us to relate the simulated fields to clinical outcomes. We review and analyze the relevant literature for the processing steps in the workflow, which are the following: tissue segmentation, source localization, and stimulation optimization. In addition, we identify shortcomings and ongoing trends with regard to, for example, segmentation quality and tissue conductivity measurements. The presented processing steps result in personalized tES based on metrics like focality and field strength, which allow for correlation with clinical outcomes.
Author Paulides, Maarten M.
Boon, Paul
van Ee, Raymond
Beumer, Steven
Carrette, Evelien
Mestrom, Rob M. C.
Klooster, Debby C. W.
AuthorAffiliation 2 Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium
3 Philips Research Eindhoven, High Tech Campus 34, 5656 AE Eindhoven, The Netherlands; raymond.van.ee@philips.com
4 Department of Radiation Oncology, Erasmus Medical Center Cancer Institute, Burgemeester Oudlaan 50, 3062 PA Rotterdam, The Netherlands
1 Department of Electrical Engineering, University of Technology Eindhoven, P.O. Box 513, 5600 MB Eindhoven, The Netherlands; paul.boon@uzgent.be (P.B.); debby.klooster@ugent.be (D.C.W.K.); evelien.carrette@uzgent.be (E.C.); m.m.paulides@tue.nl (M.M.P.); r.m.c.mestrom@tue.nl (R.M.C.M.)
AuthorAffiliation_xml – name: 3 Philips Research Eindhoven, High Tech Campus 34, 5656 AE Eindhoven, The Netherlands; raymond.van.ee@philips.com
– name: 2 Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium
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Issue 5
Keywords forward modeling
inverse modeling
transcranial electric stimulation
clinical outcome
personalized
neurostimulation
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  doi: 10.1088/2057-1976/ac0547
– volume: 2
  start-page: 19
  year: 2017
  ident: ref_27
  article-title: Adverse events of tDCS and tACS: A review
  publication-title: Clin. Neurophysiol. Pract.
  doi: 10.1016/j.cnp.2016.12.003
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Snippet Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not...
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SubjectTerms Brain research
clinical outcome
Convulsions & seizures
Customization
EEG
Electric fields
Electrodes
Electroencephalography
Epilepsy
forward modeling
Hypotheses
inverse modeling
Localization
Magnetic resonance imaging
Neuroimaging
Neurons
neurostimulation
Parkinson's disease
personalized
Quality of life
Review
Reviews
Segmentation
transcranial electric stimulation
Transcranial magnetic stimulation
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Title Personalized tDCS for Focal Epilepsy—A Narrative Review: A Data-Driven Workflow Based on Imaging and EEG Data
URI https://www.ncbi.nlm.nih.gov/pubmed/35624997
https://www.proquest.com/docview/2670093345
https://www.proquest.com/docview/2671272775
https://pubmed.ncbi.nlm.nih.gov/PMC9139054
https://doaj.org/article/bdac04628db34ba08e747bf90fdf5513
Volume 12
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