Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer

• Published in: Prostaglandins & other lipid mediators Vol. 144; p. 106338
• Main Authors: Karpisheh, Vahid, Nikkhoo, Afshin, Hojjat-Farsangi, Mohammad, Namdar, Afshin, Azizi, Gholamreza, Ghalamfarsa, Ghasem, Sabz, Gholamabas, Yousefi, Mehdi, Yousefi, Bahman, Jadidi-Niaragh, Farhad
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Cyclooxygenase-2; Dinoprostone - metabolism; E-type prostanoid receptor; Humans; Molecular Targeted Therapy - methods; Prostaglandin E2; E-type prostanoid receptor; Prostaglandin E2; Colon cancer; Cyclooxygenase-2
• ISSN: 1098-8823
• DOI: 10.1016/j.prostaglandins.2019.106338

•Colon cancer in one of the main health-related problems which is incurable particularly in advanced stages.•Prostanoids and particularly prostaglandin E2 (PGE2) are important inflammatory lipid mediators.•PGE2 plays an important role in tumorigenesis process of colon cancer.•PGE2 can be considered...