A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin-Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast

• Published in: Toxicological sciences Vol. 114; no. 2; pp. 356 - 377
• Main Authors: Yu, Xiaozhong, Robinson, Joshua F., Sidhu, Jaspreet S., Hong, Sungwoo, Faustman, Elaine M.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2010
• Subjects: Animals; Cadmium Chloride - toxicity; Cell Cycle; Cell Cycle Proteins - drug effects; cell cycle regulation; Cell Line; Cell Survival - drug effects; Comparative Genomic Hybridization; Cysteine Proteinase Inhibitors - pharmacology; Environmental Pollutants - toxicity; Fibroblasts - drug effects; Fibroblasts - pathology; Gene Expression Profiling; Gene Expression Regulation, Enzymologic - drug effects; Leupeptins - pharmacology; metals; Methylmercury Compounds - toxicity; Mice; Microarray Analysis; oxidative stress; Oxidative Stress - drug effects; Proteasome Endopeptidase Complex - drug effects; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors; Systems Toxicology; ubiquitin-proteasome pathway; Ubiquitins - metabolism

Environmental and occupational exposures to heavy metals such as methylmercury (MeHg) and cadmium (Cd) pose significant health risks to humans, including neurotoxicity. The underlying mechanisms of their toxicity, however, remain to be fully characterized. Our previous studies with Cd and MeHg have...