Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders

• Published in: Frontiers in molecular neuroscience Vol. 9; p. 78
• Main Authors: Barral, Serena, Kurian, Manju A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.09.2016; Frontiers Media S.A
• Subjects: Age; Cell differentiation; Central nervous system; Central nervous system diseases; Children; Disease; Dopamine receptors; Fetuses; Fibroblasts; Gene therapy; Inhibitory postsynaptic potentials; Motor neurons; Mutation; Neurological diseases; Neurological disorders; Neuroscience; Patients; Phenotypes; Pluripotency; Stem cells; γ-Aminobutyric acid; United Kingdom > UK; in vitro disease modeling; childhood neurological disorders; iPSCs; drug screening; gene therapies; isogenic control

The study of neurological disorders often presents with significant challenges due to the inaccessibility of human neuronal cells for further investigation. Advances in cellular reprogramming techniques, have however provided a new source of human cells for laboratory-based research. Patient-derived...