RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer’s Disease and Parkinson’s Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia

• Published in: Frontiers in neuroscience Vol. 13; p. 235
• Main Authors: Bennett, James P., Keeney, Paula M., Brohawn, David G.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 28.03.2019; Frontiers Media S.A
• Subjects: Aging; ALS; Alzheimer's disease; Amyotrophic lateral sclerosis; Animal models; Cytotoxicity; Disease; Gene expression; Genes; Genomes; Gingivitis; Lymphocytes T; Microglia; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neuroscience; Neurotoxicity; Parkinson's disease; Pathogenesis; Ribonucleic acid; RNA; Tumor necrosis factor-TNF; Vector-borne diseases; United States > US; Virginia; ALS; neurodegeneration; Alzheimer’s disease; microglia; Parkinson’s disease; gene expression

Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models of human NDD, such as rare monogenic causes of Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), show activated microglia, suggesting a potentia...