Bovine Model of Chronic Ischemic Cardiomyopathy: Implications for Ventricular Assist Device Research

• Published in: Artificial organs Vol. 37; no. 12; pp. E202 - E214
• Main Authors: Bartoli, Carlo R., Sherwood, Leslie C., Giridharan, Guruprasad A., Slaughter, Mark S., Wead, William B., Prabhu, Sumanth D., Koenig, Steven C.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.12.2013; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis; Bovine; Cardiomyopathies - diagnosis; Cardiomyopathies - etiology; Cardiomyopathies - physiopathology; Cardiomyopathies - therapy; Cattle; Chronic Disease; Coronary Circulation; Disease Models, Animal; Fibrosis; Heart failure; Heart-Assist Devices; Hemodynamics; Humans; Hypertrophy; Ischemic cardiomyopathy; Microembolization; Microspheres; Myocardial Ischemia - complications; Myocardial Ischemia - physiopathology; Myocardium - pathology; Prosthesis Design; Species Specificity; Time Factors; Ventricular assist device; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy; Ventricular Function, Left; Heart failure; Microspheres; Microembolization; Bovine; Fibrosis; Ischemic cardiomyopathy; Ventricular assist device; Apoptosis; Hypertrophy

: Ventricular assist devices (VADs) have emerged as a successful treatment option for advanced heart failure. The objective of this study was to develop a clinically relevant model of chronic ischemic cardiomyopathy to investigate functional, histological, and molecular changes during mechanical cir...