Dystrophic microglia in the aging human brain

• Published in: Glia Vol. 45; no. 2; pp. 208 - 212
• Main Authors: Streit, Wolfgang J., Sammons, Nicole W., Kuhns, Amanda J., Sparks, D. Larry
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.01.2004; Wiley-Liss
• Subjects: Adult; Aged; aging; Aging - pathology; Atrophy - pathology; Atrophy - physiopathology; Biological and medical sciences; Biomarkers; Cellular Senescence; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Fundamental and applied biological sciences. Psychology; glia; Humans; Immunohistochemistry; Isolated neuron and nerve. Neuroglia; Male; Microglia - pathology; microglia activation; Oligosaccharides - metabolism; senescence; Vertebrates: nervous system and sense organs; Human; Glial cell; Senescence; Neuroglia; Central nervous system; microglia activation; Dystrophy; aging; glia; Encephalon; Microglia

We have studied microglial morphology in the human cerebral cortex of two nondemented subjects using high‐resolution LN‐3 immunohistochemistry. Several abnormalities in microglial cytoplasmic structure, including deramification, spheroid formation, gnarling, and fragmentation of processes, were iden...