Oncostatin M Promotes Osteoblastic Differentiation of Human Vascular Smooth Muscle Cells Through JAK3-STAT3 Pathway

• Published in: Journal of cellular biochemistry Vol. 116; no. 7; pp. 1325 - 1333
• Main Authors: Kakutani, Yoshinori, Shioi, Atsushi, Shoji, Tetsuo, Okazaki, Hirokazu, Koyama, Hidenori, Emoto, Masanori, Inaba, Masaaki
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2015; Wiley Subscription Services, Inc
• Subjects: Arteries - cytology; Atherosclerosis - metabolism; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Humans; JAK3; Janus Kinase 3 - metabolism; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - metabolism; ONCOSTATIN M; Oncostatin M - metabolism; Oncostatin M - pharmacology; OSTEOBLASTIC DIFFERENTIATION; Osteoblasts - cytology; Osteoblasts - metabolism; Signal Transduction; STAT3; STAT3 Transcription Factor - metabolism; VASCULAR SMOOTH MUSCLE CELLS; ONCOSTATIN M; OSTEOBLASTIC DIFFERENTIATION; VASCULAR SMOOTH MUSCLE CELLS; JAK3; STAT3

ABSTRACT Vascular calcification is a clinically significant component of atherosclerosis and arises from chronic vascular inflammation. Oncostatin M (OSM) derived from plaque macrophages may contribute to the development of atherosclerotic calcification. Here, we investigated the stimulatory effects...