Soluble CD26 / Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding

• Published in: Scandinavian journal of immunology Vol. 73; no. 2; pp. 102 - 111
• Main Authors: Yu, D.M.T, Slaitini, L, Gysbers, V, Riekhoff, A.G.M, Kähne, T, Knott, H.M, De Meester, I, Abbott, C.A, McCaughan, G.W, Gorrell, M.D
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011
• Subjects: Adenosine Deaminase - metabolism; Adult; Cell Proliferation; Cells, Cultured; Dipeptidyl Peptidase 4 - immunology; Dipeptidyl Peptidase 4 - metabolism; Female; Humans; Indexing in process; Lymphocyte Activation; Lymphocytes - cytology; Lymphocytes - enzymology; Lymphocytes - immunology; Male; Middle Aged; Protein Binding; Solubility; Young Adult

Human CD26 has dipeptidyl peptidase-4 (DPP IV) enzyme activity and binds to adenosine deaminase (ADA). CD26 is costimulatory for lymphocytes and has a circulating soluble form (sCD26). DPP IV enzyme inhibition is a new successful type 2 diabetes therapy. We examined whether the ADA binding and catal...