Regional patterns of human cortex development correlate with underlying neurobiology

• Published in: Nature communications Vol. 15; no. 1; pp. 7987 - 21
• Main Authors: Lotter, Leon D., Saberi, Amin, Hansen, Justine Y., Misic, Bratislav, Paquola, Casey, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère, Marie-Laure, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Nees, Frauke, Banaschewski, Tobias, Eickhoff, Simon B., Dukart, Juergen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 38/61; 59/57; 59/78; 631/378/2571; 631/378/2611; 631/378/368; Adolescent; Adolescents; Adult; Aged; Aging; Aging - physiology; Brain; Brain architecture; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - growth & development; Cerebral Cortex - metabolism; Child; Child, Preschool; Children; Cholinergics; Dopamine receptors; Female; Gene expression; Glial cells; Glutamatergic transmission; Humanities and Social Sciences; Humans; In vivo methods and tests; Life Sciences; Life span; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Morphology; multidisciplinary; Neurobiology; Neuroimaging; Neuronal-glial interactions; Neurons - metabolism; Neurosciences; Population studies; Quorum sensing; Receptors; Regional development; Science; Science (multidisciplinary); Spatial distribution; Thickness; Young Adult

Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unf...