Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis

• Published in: The journal of clinical endocrinology and metabolism Vol. 93; no. 11; pp. 4245 - 4253
• Main Authors: Kazlauskaite, Rasa, Evans, Arthur T., Villabona, Carmen V., Abdu, Tariq A. M., Ambrosi, Bruno, Atkinson, A. Brew, Choi, Cheung Hei, Clayton, Richard N., Courtney, C. Hamish, Gonc, E. Nazli, Maghnie, Mohamad, Rose, Susan R., Soule, Steven G., Tordjman, Karen
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.11.2008; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adrenal Gland Diseases - diagnosis; Adrenocorticotropic Hormone - blood; Adrenocorticotropic Hormone - secretion; Adult; Biological and medical sciences; Child; Cosyntropin - pharmacology; Endocrinopathies; Fasting; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glucocorticoids - adverse effects; Humans; Hydrocortisone - blood; Hypoglycemia; Hypothalamic Diseases - diagnosis; Hypothalamo-Hypophyseal System; Hypothalamus; Medical sciences; Pituitary; Pituitary Diseases - diagnosis; Reproducibility of Results; ROC Curve; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Obesity; Nutrition; Hypothalamohypophysoadrenal axis; Peptide hormone; Nutrition disorder; Exploration; Metabolic diseases; Metaanalysis; Adrenocorticotropic hormone; Adenohypophyseal hormone; Corticotropin; Endocrinology; Nutritional status

Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. Data Sources: We searched the PubMed database from 1966–2006 for stud...