Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis

Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. Data Sources: We searched the PubMed database from 1966–2006 for stud...

Full description

Saved in:
Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 93; no. 11; pp. 4245 - 4253
Main Authors Kazlauskaite, Rasa, Evans, Arthur T., Villabona, Carmen V., Abdu, Tariq A. M., Ambrosi, Bruno, Atkinson, A. Brew, Choi, Cheung Hei, Clayton, Richard N., Courtney, C. Hamish, Gonc, E. Nazli, Maghnie, Mohamad, Rose, Susan R., Soule, Steven G., Tordjman, Karen
Format Journal Article
LanguageEnglish
Published Bethesda, MD Oxford University Press 01.11.2008
Copyright by The Endocrine Society
Endocrine Society
Subjects
Adrenal Gland Diseases - diagnosis
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - secretion
Adult
Biological and medical sciences
Child
Cosyntropin - pharmacology
Endocrinopathies
Fasting
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glucocorticoids - adverse effects
Humans
Hydrocortisone - blood
Hypoglycemia
Hypothalamic Diseases - diagnosis
Hypothalamo-Hypophyseal System
Hypothalamus
Medical sciences
Pituitary
Pituitary Diseases - diagnosis
Reproducibility of Results
ROC Curve
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Obesity
Nutrition
Hypothalamohypophysoadrenal axis
Peptide hormone
Nutrition disorder
Exploration
Metabolic diseases
Metaanalysis
Adrenocorticotropic hormone
Adenohypophyseal hormone
Corticotropin
Endocrinology
Nutritional status
Online AccessGet full text

Cover

Abstract Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. Data Sources: We searched the PubMed database from 1966–2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators. Study Selection: Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls. Data Extraction: We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios. Data Synthesis: Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89–0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74–0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P < 0.001). Conclusions: Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
AbstractList Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. Data Sources: We searched the PubMed database from 1966–2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators. Study Selection: Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls. Data Extraction: We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios. Data Synthesis: Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89–0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74–0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P < 0.001). Conclusions: Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial.CONTEXTThe diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial.Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI.OBJECTIVEOur objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI.We searched the PubMed database from 1966-2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators.DATA SOURCESWe searched the PubMed database from 1966-2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators.Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls.STUDY SELECTIONEligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls.We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios.DATA EXTRACTIONWe constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios.Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89-0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74-0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P<0.001).DATA SYNTHESISPatient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89-0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74-0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P<0.001).Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.CONCLUSIONSLow-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
CONTEXT:The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. OBJECTIVE:Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. DATA SOURCES:We searched the PubMed database from 1966-2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators. STUDY SELECTION:Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls. DATA EXTRACTION:We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios. DATA SYNTHESIS:Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as followslow-dose corticotropin test, 0.92 (95% confidence interval 0.89-0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74-0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P < 0.001). CONCLUSIONS:Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. We searched the PubMed database from 1966-2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators. Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls. We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios. Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89-0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74-0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P<0.001). Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to compare standard-dose and low-dose corticotropin tests for diagnosing HPAI. Data Sources: We searched the PubMed database from 1966–2006 for studies reporting diagnostic value of standard-dose or low-dose corticotropin tests, with patient-level data obtained from original investigators. Study Selection: Eligible studies had more than 10 patients. All subjects were evaluated because of suspicion for chronic HPAI, and patient-level data were available. We excluded studies with no accepted reference standard for HPAI (insulin hypoglycemia or metyrapone test) if test subjects were in the intensive care unit or if only normal healthy subjects were used as controls. Data Extraction: We constructed receiver operator characteristic (ROC) curves using patient-level data from each study and then merged results to create summary ROC curves, adjusting for study size and cortisol assay method. Diagnostic value of tests was measured by calculating area under the ROC curve (AUC) and likelihood ratios. Data Synthesis: Patient-level data from 13 of 23 studies (57%; 679 subjects) were included in the metaanalysis. The AUC were as follows: low-dose corticotropin test, 0.92 (95% confidence interval 0.89–0.94), and standard-dose corticotropin test, 0.79 (95% confidence interval 0.74–0.84). Among patients with paired data (seven studies, 254 subjects), diagnostic value of low-dose corticotropin test was superior to standard-dose test (AUC 0.94 and 0.85, respectively; P < 0.001). Conclusions: Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
Author Ambrosi, Bruno
Maghnie, Mohamad
Evans, Arthur T.
Abdu, Tariq A. M.
Clayton, Richard N.
Courtney, C. Hamish
Choi, Cheung Hei
Rose, Susan R.
Villabona, Carmen V.
Atkinson, A. Brew
Gonc, E. Nazli
Soule, Steven G.
Tordjman, Karen
Kazlauskaite, Rasa
AuthorAffiliation John H. Stroger Jr. Hospital of Cook County and Rush Medical College (R.K., A.T.E., C.V.V.), Chicago, Illinois 60612; Walsall Manor Hospital National Health Service Trust (T.A.M.A.), Walsall, WS2 9PS United Kingdom; University of Milan and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato (B.A.), San Donato Milanese 20097, Italy; Regional Centre for Endocrinology and Diabetes (A.B.A., C.H.C.), Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom; Queen Elizabeth Hospital (C.H.C.), Hong Kong Special Administrative Region; Keele University and North Staffordshire Hospital (R.N.C.), Stoke-on-Trent ST4 7QB,United Kingdom; Hacettepe University (E.N.G.), 06100 Ankara, Turkey; IRCCS G. Gaslini (M.M.), University of Genova, 5-16147 Genova, Italy; Cincinnati Children’s Hospital Medical Center and University of Cincinnati (S.R.R.), Cincinnati, Ohio 45229; Christchurch Hospital (S.G.S.), Christchurch, New Zealand; and Institute of Endocrinology, Metabolism, a
AuthorAffiliation_xml – name: John H. Stroger Jr. Hospital of Cook County and Rush Medical College (R.K., A.T.E., C.V.V.), Chicago, Illinois 60612; Walsall Manor Hospital National Health Service Trust (T.A.M.A.), Walsall, WS2 9PS United Kingdom; University of Milan and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato (B.A.), San Donato Milanese 20097, Italy; Regional Centre for Endocrinology and Diabetes (A.B.A., C.H.C.), Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom; Queen Elizabeth Hospital (C.H.C.), Hong Kong Special Administrative Region; Keele University and North Staffordshire Hospital (R.N.C.), Stoke-on-Trent ST4 7QB,United Kingdom; Hacettepe University (E.N.G.), 06100 Ankara, Turkey; IRCCS G. Gaslini (M.M.), University of Genova, 5-16147 Genova, Italy; Cincinnati Children’s Hospital Medical Center and University of Cincinnati (S.R.R.), Cincinnati, Ohio 45229; Christchurch Hospital (S.G.S.), Christchurch, New Zealand; and Institute of Endocrinology, Metabolism, and Hypertension (K.T.), Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
Author_xml – sequence: 1
  givenname: Rasa
  surname: Kazlauskaite
  fullname: Kazlauskaite, Rasa
  email: rasa_kazlauskaite@rush.edu
  organization: 1John H. Stroger Jr. Hospital of Cook County and Rush Medical College (R.K., A.T.E., C.V.V.), Chicago, Illinois 60612
– sequence: 2
  givenname: Arthur T.
  surname: Evans
  fullname: Evans, Arthur T.
  organization: 1John H. Stroger Jr. Hospital of Cook County and Rush Medical College (R.K., A.T.E., C.V.V.), Chicago, Illinois 60612
– sequence: 3
  givenname: Carmen V.
  surname: Villabona
  fullname: Villabona, Carmen V.
  organization: 1John H. Stroger Jr. Hospital of Cook County and Rush Medical College (R.K., A.T.E., C.V.V.), Chicago, Illinois 60612
– sequence: 4
  givenname: Tariq A. M.
  surname: Abdu
  fullname: Abdu, Tariq A. M.
  organization: 2Walsall Manor Hospital National Health Service Trust (T.A.M.A.), Walsall, WS2 9PS United Kingdom
– sequence: 5
  givenname: Bruno
  surname: Ambrosi
  fullname: Ambrosi, Bruno
  organization: 3University of Milan and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato (B.A.), San Donato Milanese 20097, Italy
– sequence: 6
  givenname: A. Brew
  surname: Atkinson
  fullname: Atkinson, A. Brew
  organization: 4Regional Centre for Endocrinology and Diabetes (A.B.A., C.H.C.), Royal Victoria Hospital, Belfast BT12 6BA, United Kingdom
– sequence: 7
  givenname: Cheung Hei
  surname: Choi
  fullname: Choi, Cheung Hei
  organization: 3University of Milan and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato (B.A.), San Donato Milanese 20097, Italy
– sequence: 8
  givenname: Richard N.
  surname: Clayton
  fullname: Clayton, Richard N.
  organization: 6Keele University and North Staffordshire Hospital (R.N.C.), Stoke-on-Trent ST4 7QB,United Kingdom
– sequence: 9
  givenname: C. Hamish
  surname: Courtney
  fullname: Courtney, C. Hamish
  organization: 5Queen Elizabeth Hospital (C.H.C.), Hong Kong Special Administrative Region
– sequence: 10
  givenname: E. Nazli
  surname: Gonc
  fullname: Gonc, E. Nazli
  organization: 7Hacettepe University (E.N.G.), 06100 Ankara, Turkey
– sequence: 11
  givenname: Mohamad
  surname: Maghnie
  fullname: Maghnie, Mohamad
  organization: 8IRCCS G. Gaslini (M.M.), University of Genova, 5-16147 Genova, Italy
– sequence: 12
  givenname: Susan R.
  surname: Rose
  fullname: Rose, Susan R.
  organization: 9Cincinnati Children’s Hospital Medical Center and University of Cincinnati (S.R.R.), Cincinnati, Ohio 45229
– sequence: 13
  givenname: Steven G.
  surname: Soule
  fullname: Soule, Steven G.
  organization: 10Christchurch Hospital (S.G.S.), Christchurch, New Zealand
– sequence: 14
  givenname: Karen
  surname: Tordjman
  fullname: Tordjman, Karen
  organization: 11Institute of Endocrinology, Metabolism, and Hypertension (K.T.), Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20849678$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18697868$$D View this record in MEDLINE/PubMed
BookMark eNp1ksFvFCEUxompsdvqzbOZxKgXqTxgZhhvm43aJjV6aBNvhGEgy8oOW2DS7H8v0117aJSEEMLve-9773GGTsYwGoReA7kACuTTRl9QQgQmLZBnaAEdr3ELXXuCFoRQwF1Lf52is5Q2hADnNXuBTkE0XSsasUC3qxCz0yHHsHNjdWNSTpUNsbrc70JeK6-2TuOfLk8uq7jH1XKIZlS-uhrTZK3Tzox6_7laVt9NVqq87JNLL9Fzq3wyr47nObr9-uVmdYmvf3y7Wi2vseYdaTEfOAjbD5SLodO9FbVtieb9MGjTaKNE0xtoOAdaWyCdUaxhHUDNqW141wh2jt4f4u5iuJuKd7l1SRvv1WjClGSpsmY1owV8-wTchCkWt0myhwxMMCjUmyM19VszyF1021K0_NuuArw7Aipp5W1Uo3bpkaNEFFvtzNEDp2NIKRordWlfdmHMUTkvgch5dnKj5Tw7Oc-uiD4-ET3m_zfOD_h98NnE9NtP9ybKtVE-ryUpixcreBYAlBsuG9oi-3CQhWn3vwQPf4n9AU9vtFM
CODEN JCEMAZ
CitedBy_id crossref_primary_10_15406_emij_2018_06_00170
crossref_primary_10_1089_neu_2013_2916
crossref_primary_10_1159_000430815
crossref_primary_10_1007_s13312_019_1507_5
crossref_primary_10_1136_archdischild_2015_308925
crossref_primary_10_1111_cen_14587
crossref_primary_10_1159_000365190
crossref_primary_10_1210_clinem_dgad579
crossref_primary_10_1136_jim_2015_000012
crossref_primary_10_4254_wjh_v7_i8_1112
crossref_primary_10_1038_pr_2017_289
crossref_primary_10_1111_imj_15033
crossref_primary_10_4158_EP10385_ED
crossref_primary_10_1016_S1773_035X_09_70249_7
crossref_primary_10_1007_s42000_020_00185_y
crossref_primary_10_4158_EP11013_OR
crossref_primary_10_1111_j_1365_2265_2009_03542_x
crossref_primary_10_1016_j_ando_2012_01_001
crossref_primary_10_1007_s12519_016_0018_x
crossref_primary_10_1080_17446651_2022_2023009
crossref_primary_10_1186_s13223_015_0075_z
crossref_primary_10_1210_jendso_bvac115
crossref_primary_10_1111_j_1365_2265_2012_04376_x
crossref_primary_10_4158_EP14423_OR
crossref_primary_10_1016_j_endonu_2013_08_001
crossref_primary_10_3389_fped_2022_981765
crossref_primary_10_1007_s10620_017_4471_8
crossref_primary_10_1016_j_ejca_2012_02_046
crossref_primary_10_1097_MPH_0000000000002784
crossref_primary_10_20945_2359_3997000000493
crossref_primary_10_1016_j_cca_2020_01_029
crossref_primary_10_1016_S1155_1941_11_53092_6
crossref_primary_10_1177_1040638716671978
crossref_primary_10_1177_0009922818825154
crossref_primary_10_1093_ndt_gfz180
crossref_primary_10_1016_j_amjmed_2015_08_021
crossref_primary_10_1111_j_1365_2265_2012_04474_x
crossref_primary_10_1111_cen_12397
crossref_primary_10_14309_ajg_0000000000001486
crossref_primary_10_1097_MEG_0000000000002694
crossref_primary_10_1210_js_2017_00198
crossref_primary_10_1097_MED_0b013e328338f608
crossref_primary_10_1111_cen_12150
crossref_primary_10_1016_j_envres_2018_02_041
crossref_primary_10_1530_EJE_17_0251
crossref_primary_10_23736_S0391_1977_18_02890_0
crossref_primary_10_1515_cclm_2018_0824
crossref_primary_10_1097_PCC_0b013e3181f36d17
crossref_primary_10_1177_0009922812462235
crossref_primary_10_1507_endocrj_EJ16_0242
crossref_primary_10_1002_hep_25573
crossref_primary_10_1002_pbc_24095
crossref_primary_10_1200_JCO_2014_56_7933
crossref_primary_10_1056_NEJMc091331
crossref_primary_10_1111_j_1365_2265_2011_04130_x
crossref_primary_10_1016_j_beem_2020_101379
crossref_primary_10_1016_j_jpeds_2015_11_026
crossref_primary_10_1210_jc_2019_00304
crossref_primary_10_1111_apt_12891
crossref_primary_10_4158_EP171861_OR
crossref_primary_10_1210_jc_2012_3576
crossref_primary_10_1097_QAI_0b013e31829260d6
crossref_primary_10_7599_hmr_2012_32_4_203
crossref_primary_10_1007_s11102_010_0270_3
crossref_primary_10_1016_j_bbadis_2018_08_001
crossref_primary_10_1002_pbc_28349
crossref_primary_10_1210_jc_2009_2697
crossref_primary_10_1155_2018_1739831
crossref_primary_10_1016_j_jhep_2010_06_034
crossref_primary_10_1186_s12902_024_01546_z
crossref_primary_10_1210_jendso_bvaa079
crossref_primary_10_1136_postgradmedj_2020_138514
crossref_primary_10_1016_S0140_6736_13_61684_0
crossref_primary_10_1210_clinem_dgaa635
crossref_primary_10_1530_EJE_09_0746
crossref_primary_10_1111_liv_15473
crossref_primary_10_1016_j_jpeds_2010_08_021
crossref_primary_10_1111_petr_14768
crossref_primary_10_1007_s12020_017_1298_1
crossref_primary_10_1159_000351705
crossref_primary_10_1007_s13631_016_0135_5
crossref_primary_10_1093_ejendo_lvae029
crossref_primary_10_1016_j_revmed_2012_12_001
crossref_primary_10_1097_XCE_0000000000000250
crossref_primary_10_2147_CMAR_S224791
crossref_primary_10_36290_vnl_2024_001
crossref_primary_10_1371_journal_pone_0068713
crossref_primary_10_1186_s13223_016_0154_9
crossref_primary_10_4158_EP10262_RA
crossref_primary_10_1097_MPG_0000000000002537
crossref_primary_10_1111_apt_14573
crossref_primary_10_5812_ijp_90891
crossref_primary_10_1002_pbc_22208
crossref_primary_10_3805_eands_10_11
crossref_primary_10_1111_j_1365_2265_2011_04080_x
crossref_primary_10_4158_EP09153_OR
crossref_primary_10_1016_j_beem_2018_03_012
crossref_primary_10_1016_j_emc_2009_01_008
crossref_primary_10_1210_jendso_bvad127
crossref_primary_10_1159_000534317
crossref_primary_10_1111_cen_14499
crossref_primary_10_1210_jc_2010_0647
crossref_primary_10_1016_j_jaip_2014_04_008
crossref_primary_10_1111_cen_14934
crossref_primary_10_1007_s11102_024_01445_5
crossref_primary_10_1111_j_1651_2227_2009_01479_x
crossref_primary_10_1136_archdischild_2015_308799
crossref_primary_10_2152_jmi_69_287
crossref_primary_10_1016_j_eprac_2024_10_009
crossref_primary_10_1155_2021_7137950
crossref_primary_10_1007_s12020_016_1042_2
crossref_primary_10_1097_QAD_0000000000002152
crossref_primary_10_1111_j_1440_1746_2012_07188_x
crossref_primary_10_1093_nop_npac053
crossref_primary_10_1136_archdischild_2016_311223
crossref_primary_10_1530_EJE_10_0621
crossref_primary_10_3389_fneur_2020_551923
crossref_primary_10_1007_s11102_015_0643_8
crossref_primary_10_1530_EJE_09_0930
crossref_primary_10_1007_s40618_017_0788_6
crossref_primary_10_1007_s40618_024_02304_7
crossref_primary_10_1210_jc_2016_2118
crossref_primary_10_1007_s12020_014_0494_5
crossref_primary_10_1136_bmj_2021_065137
crossref_primary_10_1097_MED_0000000000000473
crossref_primary_10_1111_cen_13509
crossref_primary_10_1186_1710_1492_9_30
crossref_primary_10_1016_j_cgh_2013_08_028
crossref_primary_10_1007_s11102_011_0360_x
crossref_primary_10_1002_jppr_1730
crossref_primary_10_1007_s11739_015_1308_3
crossref_primary_10_1136_bmjpo_2019_000569
crossref_primary_10_1210_jendso_bvac043
crossref_primary_10_1515_jpem_2022_0444
crossref_primary_10_1155_2022_7860272
crossref_primary_10_1080_24725625_2019_1569798
crossref_primary_10_1111_cen_15125
crossref_primary_10_1515_jpem_2014_0097
crossref_primary_10_1016_j_beem_2011_10_009
crossref_primary_10_1056_EVIDoa2200182
crossref_primary_10_1210_jc_2010_0982
crossref_primary_10_1093_pch_pxab015
crossref_primary_10_1093_pch_pxab016
crossref_primary_10_1007_BF03346560
crossref_primary_10_1507_endocrj_EJ15_0587
crossref_primary_10_1186_s13052_023_01475_y
crossref_primary_10_1111_cen_12534
crossref_primary_10_1111_cen_12655
crossref_primary_10_1155_2019_7251010
crossref_primary_10_1111_cen_13063
crossref_primary_10_1007_s12020_013_9893_2
crossref_primary_10_1093_ejendo_lvad137
crossref_primary_10_1159_000504539
crossref_primary_10_1136_rmdopen_2018_000700
crossref_primary_10_1007_s12020_017_1330_5
crossref_primary_10_1210_jc_2016_3990
crossref_primary_10_1016_j_ando_2012_11_014
crossref_primary_10_1007_s40618_022_01926_z
crossref_primary_10_3390_endocrines1020012
crossref_primary_10_1530_EJE_15_0182
crossref_primary_10_1007_s00381_013_2334_y
crossref_primary_10_1111_j_1399_3046_2010_01466_x
crossref_primary_10_1371_journal_pone_0166077
crossref_primary_10_2147_PHMT_S334576
crossref_primary_10_1093_rheumatology_keaa011
crossref_primary_10_1001_jamaophthalmol_2020_3322
crossref_primary_10_1210_jc_2010_0205
crossref_primary_10_1016_j_lpm_2014_01_007
crossref_primary_10_1530_EJE_13_0159
crossref_primary_10_1002_lary_31824
crossref_primary_10_3390_biomedicines11030904
crossref_primary_10_3389_fendo_2021_720769
crossref_primary_10_1007_s11926_015_0513_4
crossref_primary_10_1530_EJE_15_0608
crossref_primary_10_1136_jclinpath_2021_207895
crossref_primary_10_1016_j_athoracsur_2017_01_111
crossref_primary_10_1111_cen_13405
crossref_primary_10_1177_0004563216687335
crossref_primary_10_1210_clinem_dgae250
crossref_primary_10_4158_EP10011_RA
crossref_primary_10_1016_j_jpeds_2010_07_004
crossref_primary_10_1016_j_medici_2014_10_006
crossref_primary_10_3390_jcm4081536
crossref_primary_10_1080_22201009_2011_10872256
crossref_primary_10_1111_cen_14887
crossref_primary_10_1016_j_pcl_2020_08_001
crossref_primary_10_5507_bp_2024_033
crossref_primary_10_3389_fendo_2021_686317
crossref_primary_10_4158_ACCR_2017_0187
crossref_primary_10_1080_00207454_2020_1815734
crossref_primary_10_1111_cen_13559
crossref_primary_10_1097_MD_0000000000022621
crossref_primary_10_1093_pch_pxy174
crossref_primary_10_1097_MED_0b013e328339f31e
crossref_primary_10_1297_cpe_2022_0083
crossref_primary_10_1016_j_endoen_2014_02_004
crossref_primary_10_1016_j_ando_2012_03_031
crossref_primary_10_1007_s40618_024_02461_9
crossref_primary_10_1016_j_med_2020_09_004
crossref_primary_10_1136_rmdopen_2024_005251
crossref_primary_10_1016_j_eprac_2025_02_018
crossref_primary_10_1097_MPG_0000000000000848
crossref_primary_10_1016_j_jcf_2019_08_023
crossref_primary_10_1016_j_steroids_2018_01_009
crossref_primary_10_4158_EP_2017_0074
crossref_primary_10_1007_s40746_018_0126_z
crossref_primary_10_1111_cen_14071
crossref_primary_10_1097_MEG_0000000000002153
crossref_primary_10_1002_acr_23123
crossref_primary_10_4137_CGast_S18127
crossref_primary_10_1111_cen_14300
crossref_primary_10_1111_j_1445_5994_2011_02582_x
crossref_primary_10_1007_s12020_017_1505_0
crossref_primary_10_1530_EJE_13_0084
crossref_primary_10_1007_s12020_021_02701_5
crossref_primary_10_1186_s12902_016_0117_7
crossref_primary_10_1016_j_jpeds_2011_05_054
crossref_primary_10_1210_clinem_dgaa540
crossref_primary_10_1097_MPG_0000000000000877
crossref_primary_10_1002_pbc_27631
crossref_primary_10_1007_s11102_023_01368_7
crossref_primary_10_1016_j_med_2016_06_014
crossref_primary_10_1515_jpem_2020_0219
crossref_primary_10_1515_jpem_2022_0074
crossref_primary_10_20945_2359_4292_2022_0207
crossref_primary_10_1016_j_ando_2017_10_005
crossref_primary_10_1007_s40618_017_0691_1
crossref_primary_10_1530_EJE_09_0646
crossref_primary_10_3389_fendo_2022_925378
crossref_primary_10_1016_j_wneu_2022_09_006
crossref_primary_10_1016_j_heliyon_2022_e09559
crossref_primary_10_1007_s00101_022_01088_w
crossref_primary_10_1016_S1637_5017_10_72467_4
crossref_primary_10_1111_cen_12235
crossref_primary_10_1530_EJE_12_0534
crossref_primary_10_3390_diagnostics11040728
crossref_primary_10_1016_j_eprac_2021_12_015
crossref_primary_10_1136_archdischild_2019_318431
crossref_primary_10_1210_jc_2019_00295
crossref_primary_10_1530_EJE_10_0229
crossref_primary_10_1159_000368318
crossref_primary_10_1177_11795514221093316
crossref_primary_10_1186_s12967_014_0340_9
crossref_primary_10_1210_clinem_dgac151
crossref_primary_10_14712_23362936_2016_2
crossref_primary_10_1530_EJE_09_0775
crossref_primary_10_3389_fendo_2021_727628
crossref_primary_10_1016_j_beem_2018_05_010
crossref_primary_10_1007_s40618_020_01292_8
crossref_primary_10_1183_13993003_01147_2019
crossref_primary_10_1210_clinem_dgaa323
crossref_primary_10_1111_liv_12820
crossref_primary_10_2174_1874306401408010093
crossref_primary_10_1016_j_jtcvs_2016_11_030
crossref_primary_10_1007_s11154_024_09877_x
crossref_primary_10_1016_j_anai_2016_05_028
crossref_primary_10_2174_1573396315666191026100643
crossref_primary_10_1016_j_wneu_2021_06_098
crossref_primary_10_1186_1710_1492_7_13
crossref_primary_10_1038_nrendo_2016_45
crossref_primary_10_1016_j_dld_2015_08_006
crossref_primary_10_1016_j_jclinane_2013_07_002
crossref_primary_10_1007_s40618_023_02062_y
crossref_primary_10_1055_a_2180_7108
crossref_primary_10_1111_j_1365_2265_2011_04313_x
crossref_primary_10_1016_j_cgh_2011_03_033
crossref_primary_10_1080_17446651_2021_1979393
crossref_primary_10_1016_S1245_1789_10_70166_9
crossref_primary_10_2147_DMSO_S309641
crossref_primary_10_1210_clinem_dgaa793
crossref_primary_10_1210_endrev_bnae016
crossref_primary_10_1002_pbc_25780
crossref_primary_10_1111_cen_12373
crossref_primary_10_53730_ijls_v8nS1_15478
crossref_primary_10_1016_j_radonc_2011_02_015
crossref_primary_10_1111_j_1742_1241_2010_02466_x
ContentType Journal Article
Copyright Copyright © 2008 by The Endocrine Society 2008
Copyright © 2008 by The Endocrine Society
2008 INIST-CNRS
Copyright_xml – notice: Copyright © 2008 by The Endocrine Society 2008
– notice: Copyright © 2008 by The Endocrine Society
– notice: 2008 INIST-CNRS
CorporateAuthor Consortium for Evaluation of Corticotropin Test in Hypothalamic-Pituitary Adrenal Insufficiency
CorporateAuthor_xml – name: Consortium for Evaluation of Corticotropin Test in Hypothalamic-Pituitary Adrenal Insufficiency
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7QP
7T5
7TM
H94
K9.
7X8
DOI 10.1210/jc.2008-0710
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Calcium & Calcified Tissue Abstracts
Immunology Abstracts
Nucleic Acids Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Immunology Abstracts
Calcium & Calcified Tissue Abstracts
Nucleic Acids Abstracts
MEDLINE - Academic
DatabaseTitleList AIDS and Cancer Research Abstracts
MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1945-7197
EndPage 4253
ExternalDocumentID 18697868
20849678
10_1210_jc_2008_0710
00004678-200811000-00017
10.1210/jc.2008-0710
Genre Meta-Analysis
Journal Article
GroupedDBID ---
-~X
.55
.XZ
08P
0R~
18M
1TH
29K
2WC
34G
354
39C
4.4
48X
53G
5GY
5RS
5YH
8F7
AABZA
AACZT
AAIMJ
AAPQZ
AAPXW
AARHZ
AAUAY
AAVAP
AAWTL
ABBLC
ABDFA
ABEJV
ABGNP
ABJNI
ABLJU
ABMNT
ABNHQ
ABOCM
ABPMR
ABPPZ
ABPQP
ABPTD
ABQNK
ABVGC
ABWST
ABXVV
ACGFO
ACGFS
ACPRK
ACUTJ
ACYHN
ADBBV
ADGKP
ADGZP
ADHKW
ADQBN
ADRTK
ADVEK
AELWJ
AEMDU
AENEX
AENZO
AERZD
AETBJ
AEWNT
AFCHL
AFFNX
AFFZL
AFGWE
AFOFC
AFRAH
AFXAL
AGINJ
AGKRT
AGQXC
AGUTN
AHMBA
AHMMS
AJEEA
ALMA_UNASSIGNED_HOLDINGS
APIBT
ARIXL
ASPBG
ATGXG
AVWKF
AZFZN
BAWUL
BAYMD
BCRHZ
BEYMZ
BSWAC
BTRTY
C45
CDBKE
CS3
D-I
DAKXR
DIK
E3Z
EBS
EJD
EMOBN
ENERS
F5P
FECEO
FHSFR
FLUFQ
FOEOM
FOTVD
FQBLK
GAUVT
GJXCC
GX1
H13
HZ~
H~9
KBUDW
KOP
KQ8
KSI
KSN
L7B
M5~
MHKGH
MJL
N4W
N9A
NLBLG
NOMLY
NOYVH
NVLIB
O9-
OAUYM
OBH
OCB
ODMLO
OFXIZ
OGEVE
OHH
OJZSN
OK1
OPAEJ
OVD
OVIDX
P2P
P6G
REU
ROX
ROZ
TEORI
TJX
TLC
TR2
TWZ
VVN
W8F
WOQ
X7M
YBU
YFH
YHG
YOC
YSK
ZY1
~02
~H1
.GJ
3O-
7X7
88E
8FI
8FJ
AAJQQ
AAKAS
AAPGJ
AAQQT
AAUQX
AAWDT
AAYJJ
ABDPE
ABUWG
ABXZS
ACFRR
ACVCV
ACZBC
ADMTO
ADNBA
ADZCM
AEMQT
AEOTA
AFFQV
AFKRA
AFYAG
AGMDO
AGORE
AHGBF
AI.
AJBYB
AJDVS
ALXQX
APJGH
AQDSO
AQKUS
AVNTJ
BENPR
BPHCQ
BVXVI
CCPQU
EIHJH
FEDTE
FYUFA
HMCUK
HVGLF
IAO
IHR
INH
ITC
J5H
M1P
MBLQV
NU-
OBFPC
PHGZM
PHGZT
PQQKQ
PROAC
PSQYO
TMA
UKHRP
VH1
WHG
X52
ZGI
ZXP
AAYXX
CITATION
IQODW
PJZUB
PPXIY
CGR
CUY
CVF
ECM
EIF
NPM
7QP
7T5
7TM
H94
K9.
7X8
ID FETCH-LOGICAL-c4907-4d418fbd248d9cbf85f70c4bddce6cea86be1644125f109ea363911542f649683
ISSN 0021-972X
IngestDate Thu Jul 10 23:03:41 EDT 2025
Mon Jun 30 12:40:43 EDT 2025
Mon Jul 21 06:00:52 EDT 2025
Mon Jul 21 09:16:04 EDT 2025
Tue Jul 01 04:01:28 EDT 2025
Thu Apr 24 22:54:04 EDT 2025
Fri May 16 04:03:13 EDT 2025
Fri Feb 07 10:35:25 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords Obesity
Nutrition
Hypothalamohypophysoadrenal axis
Peptide hormone
Nutrition disorder
Exploration
Metabolic diseases
Metaanalysis
Adrenocorticotropic hormone
Adenohypophyseal hormone
Corticotropin
Endocrinology
Nutritional status
Language English
License CC BY 4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c4907-4d418fbd248d9cbf85f70c4bddce6cea86be1644125f109ea363911542f649683
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMID 18697868
PQID 3164413831
PQPubID 2046206
PageCount 9
ParticipantIDs proquest_miscellaneous_69753532
proquest_journals_3164413831
pubmed_primary_18697868
pascalfrancis_primary_20849678
crossref_citationtrail_10_1210_jc_2008_0710
crossref_primary_10_1210_jc_2008_0710
wolterskluwer_health_00004678-200811000-00017
oup_primary_10_1210_jc_2008-0710
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2008-November
PublicationDateYYYYMMDD 2008-11-01
PublicationDate_xml – month: 11
  year: 2008
  text: 2008-November
PublicationDecade 2000
PublicationPlace Bethesda, MD
PublicationPlace_xml – name: Bethesda, MD
– name: United States
– name: Washington
PublicationTitle The journal of clinical endocrinology and metabolism
PublicationTitleAlternate J Clin Endocrinol Metab
PublicationYear 2008
Publisher Oxford University Press
Copyright by The Endocrine Society
Endocrine Society
Publisher_xml – name: Oxford University Press
– name: Copyright by The Endocrine Society
– name: Endocrine Society
References 19047996 - Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):68-9
References_xml – reference: 19047996 - Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):68-9
SSID ssj0014453
Score 2.4449866
SecondaryResourceType review_article
Snippet Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to...
CONTEXT:The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. OBJECTIVE:Our objective was to...
The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Our objective was to compare standard-dose...
Context: The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial. Objective: Our objective was to...
The diagnostic value of tests for detecting hypothalamic-pituitary adrenal insufficiency (HPAI) is controversial.CONTEXTThe diagnostic value of tests for...
SourceID proquest
pubmed
pascalfrancis
crossref
wolterskluwer
oup
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4245
SubjectTerms Adrenal Gland Diseases - diagnosis
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - secretion
Adult
Biological and medical sciences
Child
Cosyntropin - pharmacology
Endocrinopathies
Fasting
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glucocorticoids - adverse effects
Humans
Hydrocortisone - blood
Hypoglycemia
Hypothalamic Diseases - diagnosis
Hypothalamo-Hypophyseal System
Hypothalamus
Medical sciences
Pituitary
Pituitary Diseases - diagnosis
Reproducibility of Results
ROC Curve
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Title Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-200811000-00017
https://www.ncbi.nlm.nih.gov/pubmed/18697868
https://www.proquest.com/docview/3164413831
https://www.proquest.com/docview/69753532
Volume 93
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSAgJIe4UxsgDPFVBuTiJw1tVNg1Yh4Ra1LfISWytrEtKLkLbr-ccx81FasXlJaoSy018vhyfE_v7DiFvvVDS0HaFyT0BCQpMUWbshIlJU47TgyfiAPnOs3P_dEE_L71l9ylbsUuq-H1ys5NX8j9WhXNgV2TJ_oNl207hBPwG-8IRLAzHv7LxNMdzeVUg62kMQWOl1BXGF9cbMABfY615c7Oq6lXFi2tzzJG2rVQ2ylpJRyDvsqE7X4mKcy1Q0g9YEUY9dYmWSCmyNAeHk3USTthDnK-3koToxPnNmtflJdc1-L7xsp0E2gh-UlQXddHt1f6-UsBsqGpTXlyJrNuIO4nTWiEMMvyf4NNmg48WTLP3eo4Yd4YEqpJ664ibUolbwNk9t4rLszv9PSSs6O-VFiVDMpbVzWvbtfzzr9HJ4uwsmh8v57fJHQfyCSx18fHTl3a5iVItV6rvSjMkkN7U73sQuzR8yPsbXsKoy6YKyq40Bdr8ynHnQ3mpiA-98GX-kDzQeYcxaUD0iNwS2WNyd6Z3VjwhiwGWDIUlA7Bk7MGSobFkDLD0weBGH0lPyeLkeD49NXXJDTOhoRXAK0ptJuPUoSwNk1gyTwZWQuM0TYSfCM78WNgYQjuetK1QcBciXFR0cqRPQ5-5z8hBlmfiBTESCT1J8BBBnEIE5DLppJ5LqSW5Ywtpj8h4O5hRovXosSzKOsK8FIY--pHoIqkw9CPyrm29aXRY9rQzwC77mphNk6OB0drGjsXgGQI2IodbK0b6DSsjVz22y1y48TftZfDFuMDGM5HXZeQjS91znRF53ti-uw8G15gPXZsDMEQN2zlSqTr8Nbo3hiqOSu7BDl7-8b9ekXvdC3ZIDqqiFq8hTq7iI4Xx31eNvy4
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Corticotropin+tests+for+hypothalamic-pituitary-+adrenal+insufficiency%3A+a+metaanalysis&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Kazlauskaite%2C+Rasa&rft.au=Evans%2C+Arthur+T&rft.au=Villabona%2C+Carmen+V&rft.au=Abdu%2C+Tariq+A+M&rft.date=2008-11-01&rft.issn=0021-972X&rft.volume=93&rft.issue=11&rft.spage=4245&rft_id=info:doi/10.1210%2Fjc.2008-0710&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon