Metabolic analysis of antibody producing CHO cells in fed-batch production - Dean, Jason; Reddy, Pranhitha (Biotechnology and bioengineering, 2013)
Keywords: Amino Acids - metabolism; Animals; Antibodies, Monoclonal - analysis; Antibodies, Monoclonal - biosynthesis; Antibodies, Monoclonal - chemistry; Cell Culture Techniques - methods; Cells; Chinese hamster ovary cells; CHO Cells; Cricetinae; Cricetulus; fed-batch mAb production; Genotype & phenotype; Glucose - metabolism; Industrial production; Isotope Labeling; Isotopes; Lactic Acid - metabolism; metabolic flux analysis; Metabolism; Metabolites; Metabolome; Phosphoenolpyruvate Carboxykinase (ATP) - metabolism; Proteins; Pyruvic Acid - metabolism; Recombinant Proteins - analysis; Recombinant Proteins - biosynthesis; Recombinant Proteins - chemistry; Ribose - metabolism; Rodents; stable isotope tracers; Stable isotopes