A Within-Group Design of Nontreatment Seeking 5-HTTLPR Genotyped Alcohol-Dependent Subjects Receiving Ondansetron and Sertraline

• Published in: Alcoholism, clinical and experimental research Vol. 33; no. 2; pp. 315 - 323
• Main Authors: Kenna, George A., Zywiak, William H., McGeary, John E., Leggio, Lorenzo, McGeary, Chinatsu, Wang, Shirley, Grenga, Andrea, Swift, Robert M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2009; Wiley
• Subjects: 5-HTTLPR; Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcoholism; Alcoholism - genetics; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; Biological and medical sciences; DNA - genetics; Early onset alcoholism; Female; Genotype; Genotypes; Humans; L/L; Late onset alcoholism; Male; Medical sciences; Middle Aged; Ondansetron; Ondansetron - therapeutic use; Patient Acceptance of Health Care - psychology; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; S/L; S/S; Self Administration; Serotonin Antagonists - therapeutic use; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin Uptake Inhibitors - therapeutic use; Sertraline; Sertraline - therapeutic use; Socioeconomic Factors; Toxicology; Young Adult; Psychotropic; L/L; Reuptake inhibitor; Selective serotonin reuptake inhibitor; Design; Alcoholic beverage; S/L; Age of onset; S/S; Dependence; Antidepressant agent; Genotypes; Human; Late; Serotonin; 5-HTTLPR; Serotonin antagonist; Alcoholism; Late onset alcoholism; Genotype; Sertraline; Naphthylamine derivatives; 5-HT3 Serotonine receptor; Neurotransmitter; Early; Early onset alcoholism; Antiemetic; Ondansetron

Background:  Serotonergic mechanisms are associated with the development of alcohol dependence (AD), however, studies evaluating serotonergic medications have produced conflicting results. One hypothesis suggests that differential response may be due to a functional polymorphism of the 5‐HTTLPR prom...