Sex modifies the APOE-related risk of developing Alzheimer disease

• Published in: Annals of neurology Vol. 75; no. 4; pp. 563 - 573
• Main Authors: Altmann, Andre, Tian, Lu, Henderson, Victor W., Greicius, Michael D.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2014; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Amyloid beta-Peptides - cerebrospinal fluid; Apolipoproteins E - classification; Apolipoproteins E - genetics; Biomarkers; Case-Control Studies; Cognitive Dysfunction - genetics; Databases, Factual - statistics & numerical data; Female; Follow-Up Studies; Genetic Predisposition to Disease - genetics; Genetic Testing; Health risk assessment; Humans; Male; Medical research; Proportional Hazards Models; Risk Factors; Sex Factors; tau Proteins - cerebrospinal fluid

Objective The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case–control studies suggest the APOE4 link to AD is stronger in women. We examined the APOE4‐by‐sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI)/AD or from M...